The aim of this study was to analyze the prevalence of multimorbidity of five chronic non-communicable diseases (hypertension, diabetes, coronary heart disease, stroke, and chronic obstructive pulmonary disease) and its influencing factors among male detoxification addicts under compulsory isolations in Yunnan Province.

The multistage random cluster sampling method was adopted to select 1 021 male detoxification addicts under compulsory isolation from compulsory detoxification centers in Yunnan Province, and each participant received on-site questionnaire surveys and physical examinations. The Structure Equation Modeling (SEM) was used to analyze the influencing factors of multimorbidity of five chronic non-communicable diseases (NCDs).

Among the study population, the prevalence of individuals who suffered from chronic NCDs mutimorbidity was 6.6%. The results of the SEM analysis indicated that age, sleep quality, and self-rated health status had both direct and indirect effects on mutimorbidity of chronic NCDs, with standardized total effects of 0.474(95% CI: 0.290-0.680), 0.257 (95% CI: 0.076-0.486), and 0.293 (95% CI: 0.130-0.483), respectively. Age had an indirect effect through mental health and self-rated health on chronic NCDs mutimorbidity, with standardized indirect effects of 0.046(95% CI: 0.016-0.095), and 0.066 (95% CI: 0.033-0.103), respectively. Sleep quality had an indirect effect through mental health and self-rated health, with standardized indirect effects of 0.043 (95% CI: 0.018-0.081), and 0.033 (95% CI: 0.015-0.058), respectively. Self-rated health status had an indirect effect through mental health, with standardized indirect effects of 0.073 (95% CI: 0.033-0.138). Mental health and central obesity had direct effect on chronic NCDs mutimorbidity, with standardized direct effects of 0.229 (95% CI: 0.111-0.348), 0.198 (95% CI: 0.085-0.310), respectively.

The findings suggest future measures to strengthen the prevention, control, and management of chronic NCDs should focus more on male detoxification addicts who are older and have poor sleep quality, poor mental health, central obesity, and poor self-rated health, to reduce the risk of NCD multimorbidity.

To analyze the trends in the burden of cervical cancer attributable to smoking in China from 1990 to 2021, and to explore the disease burden patterns across regions with different Socio-demographic Index (SDI) levels, thereby providing a scientific basis for formulating targeted tobacco control measures and cervical cancer prevention strategies.

Based on data from the Global Burden of Disease (GBD) Study 2021, mortality and disability-adjusted life year(DALY) rates of cervical cancer attributable to smoking in China and five SDI regions among individuals aged 25-94 years were extracted. Joinpoint regression was used to analyze the temporal trends in age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR). The Age-Period-Cohort (APC) model was employed to assess age, period, and cohort effects.

From 1990 to 2021, both the ASMR and ASDR of cervical cancer attributable to smoking in China decreased significantly, with average annual percentage changes (AAPCs) of -2.177% (95% CI: -2.592~-1.759) and -2.054% (95% CI:-2.280~-1.826), respectively. The overall burden in China remained consistently lower than the average of its corresponding SDI region. Regional comparisons revealed that the largest decline in mortality occurred in the middle SDI region (AAPC=-2.874%), while the fastest decline in ASDR was observed in the low SDI region (AAPC=-2.863%). The high SDI region showed the smallest declines for both metrics. In China, age-specific analyses showed that the most pronounced declines in ASMR for cervical cancer attributable to smoking were observed in the 70-74 and ≥95 years age groups. The ASDR exhibited a unimodal distribution with age, peaking at 57 years, and showed the largest decline in the 70-74 years age group. However, the disease burden in the 30-59 years age group still showed an increasing trend in some SDI regions. APC model analysis further indicated net drifts of -0.540% for ASMR and -1.946% for ASDR. Both period and cohort effects decreased significantly, with the cohort effect being the most prominent, showing an 82.97% reduction in the risk of DALY rates attributable to smoking from the 1895 to the 1990 birth cohorts.

From 1990 to 2021, the burden of cervical cancer attributable to smoking in China showed a significant overall decline, but with notable regional and age heterogeneities. Substantial improvements were observed in low and middle-high SDI regions and among older age groups, while the burden in young and middle-aged populations increased in some regions. Future prevention and control efforts should focus on the young and middle-aged population and promote tailored strategies across different regions.

To analyze the disease burden of adverse effects of medical treatment (AEMT) among Chinese residents from 1990 to 2021, thereby providing a reference for the health department to formulate patient safety policies.

The mortality,incidence, disability-adjusted life years(DALYs) data of AEMT and regional sampling data were extracted from the Global Health Data Exchange and the National Health Service and Quality Safety Report. The trends and effects were analyzed using the Joinpoint-jump model and Age-period-cohort model, and regional differences were analyzed by hierarchical clustering.

The overall trends of incidence, mortality and DALYs of AEMT from 1990 to 2021 gradually declined. The AAPCs were -1.28%, -5.59% and -6.47%,respectively. The comparability ratio (CR) values of overall incidence and mortality were 0.99 and 1.02, respectively. The number of male AEMT cases decreased from 208 100 to 170 700, while the number of female cases dropped from 224 100 to 172 700. The risk of death was the highest among residents over 95 years old (RR=10.55, 95% CI: 5.93-18.75), which was 2.27 times that of residents aged 0-4 years (RR=4.65, 95% CI: 3.83-5.64). The risk of DALYs increased among those aged 0-4 years (RR=8.56, 95% CI: 5.83-12.55),which was 14.57 times that of residents aged 50-54 years (RR=0.59, 95% CI: 0.47-0.73). In 2022, the regional clustering of AEMT reported per hospital was categorized into 2 clusters, Zhejiang (632.16 cases per hospital) belonged to the high-high cluster, while Tibet (49.23 cases per hospital) belonged to the low-low cluster.

The burden of AEMT in China is gradually decreasing. It is necessary to consider the prevention and control strategies for key populations, including those aged 0-4 years and above 80 years, as well as remote areas, leverage artificial intelligence to reduce AEMT, and promote the development of medical safety to a higher level.

To analyze the current status and trends of hypertensive heart disease burden attributable to high BMI in China and globally from 1990 to 2021, in order to provide data support for the development of obesity and cardiovascular disease prevention and control strategies in China and worldwide.

Data on disability-adjusted life years (DALYs) and deaths from hypertensive heart disease attributable to high BMI were extracted from the 2021 Global Burden of Disease database. The total DALYs and number of deaths caused by high BMI-related hypertensive heart disease in China and globally in 2021, as well as the age-standardized mortality rate and trends from 1990 to 2021, were described. The Joinpoint regression model was used to calculate the average annual percentage change (AAPC) in age-standardized DALY and mortality rates from 1990 to 2021 in both China and globally.

In 2021, the age-standardized mortality rate attributable to high BMI-related hypertension heart disease in China was 6.90 per 100 000 (AAPC=-1.09, P<0.001), and the age-standardized DALY rate was 120.03 per 100 000 (AAPC=-1.41, P<0.001), both showing a downward trend. Globally, the age-standardized mortality rate was 7.21 per 100 000 (AAPC=0.19, P<0.001), and the age-standardized DALY rate was 147.34 per 100 000 (AAPC=0.07),showing a slow upward trend.

From 1990 to 2021, the age-standardized mortality rate and DALY rate for hypertensive heart disease attributable to high BMI in China showed a downward trend, contrary to the global trend. However,the burden was heavier among women and the elderly. Therefore, it is crucial to emphasize obesity prevention and control strategies for the elderly, promote healthy lifestyle habits, and adopt targeted interventions to reduce the disease burden.

To systematically analyze the research hotspots, development trends and regional differences in the field of cognitive frailty of patients with chronic diseases at home and abroad from 2013 to 2025 through bibliometric methods, so as to provide directional guidance for future research.

Literature on the theme of cognitive frailty among patients with chronic diseases was collected from CNKI, VIP, Wanfang, and the Web of Science core collection, and a total of 691 articles(220 in Chinese and 471 in English) were visualized using CiteSpace and VOSviewer.

A total of 220 Chinese and 471 English articles were included. The annual number of publications on cognitive frailty among patients with chronic diseases globally showed an increasing trend. International research mainly focused on pathological mechanisms (such as blood-brain barrier injury, neuroinflammation-metabolic coupling mechanism) and digital health interventions (such as virtual reality training, artificial intelligence prediction model). However, domestic research focused on the early screening and risk assessment of community population and on the standardized management of patients with chronic diseases such as hypertension and diabetes (such as drug adjustment, follow-up management). The keyword burst showed that “physical activity” (English) and “influencing factor analysis” (Chinese) had emerged simultaneously since 2023, marking that intervention research had become a common focus. Compared with foreign countries, the analysis of the cooperation network between authors and institutions in China showed that the substantive cooperation between interdisciplinary and cross-team was weak.

Future research should align with international mechanistic explorations and local clinical practice needs, prioritizing breakthroughs in digital technology clinical translation and the establishment of interdisciplinary health management models. This method may provide a new way to delay cognitive frailty in patients with chronic diseases.

To investigate the correlation and potential causal association between abdominal obesity and bone mineral density(BMD) in people of different age groups.

This study combined a cross-sectional study with Mendelian randomization (MR) analysis.Cross-sectional study data were derived from the U.S. National Health and Nutrition Examination Survey (NHANES) 2011—2018. A total of 7 452 participants aged 20-60 years were included. Weighted linear regression analysis was employed to investigate the association between a body shape index (ABSI) and total body less head bone mineral density (TB-BMD). The MR study utilized a two-sample MR analysis to explore the causal relationship between genetically predicted waist circumference-adjusted for body mass index(WCadjBMI), an index of abdominal obesity, and TB-BMD.

Cross-sectional analysis revealed a significant negative correlation between ABSI and TB-BMD(β=-3.53, 95% CI: -4.146~-2.915, P<0.001), which was more pronounced in males and individuals aged 45-60 years. In the 45-60 age group, an “inverted U-shaped” non-linear relationship was observed between ABSI and pelvic BMD (inflection point=0.076). MR analysis indicated a negative causal relationship between WCadjBMI and TB-BMD (β=-0.16, 95% CI: -0.26~-0.07,P<0.01), which was significant across age groups of <15 years, 30-45 years, and >60 years.

Abdominal obesity is clearly associated with bone loss, and this negative effect varies among different age and sex groups. Maintaining abdominal fat at a low level before significant bone loss occurs is crucial for preserving skeletal health.

This study aims to investigate the mechanism by which circular RNA hsa_circ_0058493 mediates arsenic exposure-induced apoptosis in lung cells.

A549 and BEAS-2B cells were exposed to different concentrations of sodium arsenite (NaAsO₂), and the half-maximal inhibitory concentration (IC₅₀) of NaAsO₂ was determined by the CCK-8 assay. The effects of three arsenic species (NaAsO₂, MMA, DMA) on hsa_circ_0058493 expression were analyzed by real-time quantitative PCR (RT-qPCR). After silencing hsa_circ_0058493 with siRNA, cell viability, mitochondrial membrane potential, and apoptosis were evaluated using CCK-8, JC-1 staining, and Hoechst 33342/PI double staining, respectively. The JAK2/STAT3 signaling pathway and related protein expression were assessed by Western blotting.

NaAsO₂ significantly reduced cell viability(IC₅₀: 35.03 μmol/L for A549, 7.809 μmol/L for BEAS-2B) and specifically induced the upregulation of hsa_circ_0058493 (P<0.05), while MMA and DMA showed no significant effects. Downregulating hsa_circ_0058493 reduced cell viability, depolarized mitochondrial membrane potential, and increased apoptosis (P<0.05). Western blotting showed that depleting hsa_circ_0058493 suppressed JAK2/STAT3 phosphorylation and downregulated c-Myc, CyclinD1, XIAP, and BCL-2 expression levels (P<0.05).After downregulating hsa_circ_0058493, cells were treated with NaAsO₂, resulting in a further decrease in cell viability, and STAT3 protein expression differed between the two cell lines.

Downregulation of hsa_circ_0058493 induced decreased cell viability and apoptosis, which were associated with inhibition of JAK2/STAT3 pathway activity, suggesting that hsa_circ_0058493 may be involved in arsenic-induced lung cell apoptosis by regulating the JAK2/STAT3 signaling pathway.

To investigate the effects of combined exposure of benzo[a]pyrene (B[a]P) and 2,2',4,4'-tetrabromobiphenyl ether (BDE-47), which widely coexist in the environment as endocrine-disrupting chemicals, on the proliferation, migration and invasion of mammary epithelial cells and their possible tumorigenic mechanisms.

Human mammary epithelial MCF-10A cells were treated with 1 μM B[a]P and gradient concentrations of BDE-47, alone or in combination. Cell cycle and apoptosis were detected by flow cytometry. Cell proliferation, migration and invasion were detected by CCK-8 method, scratch test and Transwell chamber. Protein expression levels of epithelial-to-mesenchymal transition(EMT) related markers and β-catenin were detected by Western blot.

Compared with control group, flow cytometry results showed that exposure to B[a]P and BDE-47 alone and in combination significantly decreased the proportion of G0/G1 cells and significantly increased the proportion of S and G2/M cells(P<0.05), but did not induce apoptosis in MCF-10A cells(P>0.05). The expression of cyclin-dependent kinase 4(CDK4) and CyclinD1 increased significantly(P<0.05), and CDK6 expression level had no significant difference (P>0.05). CCK-8 results showed that B[a]P and BDE-47, both alone and in combination, significantly enhanced cell viability, with the combined exposure producing a stronger effect(P<0.05). Scratch wound and Transwell assays demonstrated that both single and combined exposures enhanced cell migration and invasion(P<0.05), with the combined exposure group showing the most pronounced effects. Western blot analysis showed that EMT-related epithelial-associated proteins E-cadherin and ZO-1 were down-regulated (P<0.05), while mesenchymal associated proteins N-Cadherin, Vimentin and Snail were up-regulated (P<0.05), and the protein level of β-catenin was also increased(P<0.05), suggesting activation of the Wnt/β-catenin signaling pathway.

Combined exposure of B[a]P and BDE-47 promoted proliferation, migration and invasion of mammary epithelial cells, and the combined effect was stronger, which may induce EMT process of mammary epithelial cells through Wnt/β-catenin signaling pathway to play a tumorigenic role.

To provide scientific evidence for promoting the application of food nutrition labeling and the construction of nutritional health canteens.

Two workplace canteens in Xiamen City that received catering services from the same catering enterprise and were comparable in unit type, canteen size, meal provision, and diner number and composition were selected as study sites, with one designated as the intervention canteen and the other as the control. A traffic light catering food nutrition labeling system was designed and implemented in the intervention canteen. Over a six-month period, per capita consumption of cooking oil, salt, and sugar was monitored in both canteens. In addition, the use of condiments and cooking oil for 110 regular dishes in the intervention canteen was recorded before and after labeling implementation. Validated questionnaires were administered twice to diners in the intervention canteen to assess satisfaction before and after the implementation of the traffic light nutrition labeling.

One month post-implementation, the intervention canteen showed significantly lower per capita consumption of cooking oil, salt, and sugar than the control canteen (F=1 405.805, P<0.001; F=1 798.037，P<0.001; F=1 018.140, P<0.001). Throughout the six months, these metrics progressively decreased in the intervention canteen (P<0.001). After six months, the intervention canteen demonstrated reduced usage of salt, MSG/chicken essence, sugar, soy sauce, other condiments, and cooking oil in regular dishes (P<0.01). Post-implementation surveys indicated statistically significant improvements in diner satisfaction regarding meal quality, nutrition/health services, general services, and overall experience (P<0.01).

The traffic light food labeling system effectively facilitated the “Three Reductions” in nutritional health canteen practice.

To understand the residue levels of anticoccidial drugs in chicken meat and eggs in Henan Province and to assess the risk of dietary exposure.

A total of 323 chicken and 326 eggs were randomly collected in Henan Province from 2022 to 2024, and residues of four anticoccidial drugs were detected according to the standard operating procedures in the“National Food Contaminants and Hazardous Factors Risk Monitoring Manual”, the χ² test was used for the comparison of rates.The exposure levels of anticoccidial drugs were calculated through probabilistic assessment methods combined with the residents’ consumption data of chicken and eggs, and the health risks of exposure were evaluated using hazard quotients.

The overall detection rate of anticoccidial drugs in chicken and eggs was 18.95%, and the passing rate was 99.85%.The detection rate of chicken was higher than that of eggs (χ²=107.602, P<0.001). The detection rates of anticoccidial drugs in chicken from high to low were diclazuril, nicarbazin, and toltrazuril sulfone (χ²=188.986, P<0.001). The detection rate of diclazuril in eggs was higher than that of nicarbazin (χ²=6.500, P=0.011). Toltrazuril was not detected in chicken and egg samples. There were no statistically significant differences in the detection rates of anticoccidial drugs in bulk and prepackaged chicken and eggs (χ²=0.406, P=0.524; χ²=0.694, P=0.405). There was no statistically significant difference in the detection rates of anticoccidial drugs in chicken samples from different circulation links (χ²=5.106, P=0.078). The detection rate of anticoccidial drugs in egg samples from online stores was higher than that from farmers’ markets and shops (χ²=8.514, P=0.014). The P₉₉ exposure levels of diclazuril and nicarbazin in chicken, and diclazuril in eggs were 2.78×10^-2 [μg/(kg BW·d)],2.14×10^-3 [μg/(kg BW·d)], 6.41×10^-4 [μg/(kg BW·d)], respectively. The hazard quotients of diclazuril in chicken and eggs for 99% of adults in Henan Province were 9.27×10^-4 and 0.21×10^-4 respectively, and the hazard quotient of nicarbazin in chicken for 99% of adults was 5.35×10^-6.

The overall detection rate of anticoccidial drugs in chicken and eggs is relatively low in Henan Province, and the risk of human intake is also relatively low.