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Mendelian randomization study on the causal relationship between six dietary-derived antioxidants and telomere length
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Ya-xian ZENG1, Jing ZI1, Yi-fan HU1, Guo-chen MA1, Hao-qi LI1, Jing-yuan XIONG1, Cheng CHENG2, 3
Modern Preventive Medicine | 2025, 52(5) : 843 - 847
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Modern Preventive Medicine | 2025, 52(5): 843-847
• Nutrition and Food Hygiene •
Mendelian randomization study on the causal relationship between six dietary-derived antioxidants and telomere length
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Ya-xian ZENG1, Jing ZI1, Yi-fan HU1, Guo-chen MA1, Hao-qi LI1, Jing-yuan XIONG1, Cheng CHENG2, 3
Affiliations
  • West China School of Public Health, Sichuan University / West China Fourth Hospital, Chengdu, Sichuan 610041, China
Published: 2025-03-10 doi: 10.20043/j.cnki.MPM.202410443
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Objective

To explore the causal relationship between six dietary-derived antioxidants and telomere length through a two-sample Mendelian randomization analysis.

Methods

The research utilized genome-wide association data concerning vitamin C,vitamin E, vitamin D, carotenoids, retinol, urate, and telomere length. Various sensitivity analyses were conducted using inverse variance weighted (IVW) method, MR-Egger regression, weighted median method, weighted model, MR-lap, and MR-PRESSO. The effectiveness of genetic instruments was assessed using F-statistics, Q-statistics, and the MR-Egger intercept test.

Results

The IVW method indicated a negative correlation between urate levels and telomere length (βIVW: -0.050; 95%CI: -0.070 to -0.031; PIVW=4.93×10-7), a finding supported by the other three sensitivity analyses. Additionally, after removing outlier SNPs using MR-PRESSO, the results remained robust (P=2.28×10-7). No statistically significant causal effects were observed for the other five dietary-derived antioxidants concerning telomere length.

Conclusion

There exists a causal relationship between serum urate levels and telomere length.

Antioxidants  /  Telomere length  /  Mendelian randomization  /  Causal association
Ya-xian ZENG, Jing ZI, Yi-fan HU, Guo-chen MA, Hao-qi LI, Jing-yuan XIONG, Cheng CHENG. Mendelian randomization study on the causal relationship between six dietary-derived antioxidants and telomere length[J]. Modern Preventive Medicine, 2025 , 52 (5) : 843 -847 . DOI: 10.20043/j.cnki.MPM.202410443
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Year 2025 volume 52 Issue 5
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Article Info
doi: 10.20043/j.cnki.MPM.202410443
  • Receive Date：2024-10-24
  • Online Date：2026-03-18
  • Published：2025-03-10
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  • Received：2024-10-24
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    West China School of Public Health, Sichuan University / West China Fourth Hospital, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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