To investigate the association between UHR and abdominal aortic calcification (AAC) in people aged≥40.

We used data from the 2013—2014 National Health and Nutrition Examination Survey (NHANES), including a total of 3 008 participants. Multiple logistic regression, subgroup analysis and restricted cubic spline (RCS) analysis were used to explore the correlation between UHR and AAC prevalence.

UHR was positively associated with AAC risk in all participants. Compared with the lowest UHR quartile, the highest quartile had a 134.6% increased risk of AAC (OR=2.346, 95%CI: 1.594-3.453). Interaction analysis showed that there was no significant interaction between UHR grouping and gender or age. Gender stratification showed a 213.6% increase in AAC in the Q4 group of females compared with the Q1 group (OR=3.136, 95%CI: 1.884-5.221), while no statistical significance was achieved in males (P=0.113). Age stratification revealed that for those over 60 years old, the risk of AAC in the Q2, Q3, and Q4 groups increased by 118.6% (OR=2.186, 95%CI: 1.140-4.191), 147.4% (OR=2.474, 95%CI: 1.464-4.181), and 347.8% (OR=4.478, 95%CI: 2.580-7.773) compared with the Q1 group, respectively, while in the 40-60 years old group, it did not reach statistical significance (P=0.338). RCS analysis showed that there was a nonlinear relationship between UHR and AAC.

s UHR is an independent risk factor for AAC, and the higher level of UHR, the higher risk of AAC. The association between UHR and AAC is more significant in females and people over 60 years old.

To investigate the impact of omorbidities on sleep duration in middle-aged and elderly individuals in China.

This study was a cross-sectional analysis using data from the 2020 China health and retirement longitudinal study database to examine the relationship between comorbidities and sleep duration. Directed acyclic graphs were used to identify potential confounding factors. Overlap weighting and linear regression with double confounding adjustment were applied to minimize group differences and make inter-group comparisons more akin to a randomized trial. The impact of comorbidities on sleep duration was explored through linear regression, and sensitivity analyses were conducted to verify the robustness of the results, with subgroup analyses performed.

A total of 17 010 participants aged 45 years and older were included in the analysis. The results indicated that comorbidities affected individual sleep duration. Individuals with multimorbidity had a sleep duration that was approximately 0.12 hours shorter compared with those without multimorbidity (B=-0.121 4, P<0.05). Sensitivity analysis showed an E-value of 1.48. Furthermore, this impact was more pronounced in females (B=-0.159 4, P<0.05) and in the middle-aged group (45-60 years) (B=-0.225 8, P<0.05).

There is a difference in sleep duration between middle-aged and elderly individuals with chronic disease comorbidity, with a more pronounced effect observed in females and the middle-aged group. The study utilizes overlap weighting, demonstrating the significant impact of comorbidities on sleep duration, providing empirical evidence for improving sleep conditions in this population.

To investigate the effects of the combination of all-trans retinoic acidand tofacitinib on human fibroblast-like synoviocytes from rheumatoid arthritis and explorethe mechanisms of autophagy and apoptosis in the NF-κB signalingpathway.

Cells were adaptively cultured and stimulated with TNF-α and IL-1β.Subsequently, HFLS-RA cells were intervened with ATRA, tofacitinib, and their combination.Cell proliferation rate, migration ability, inflammatory cytokine concentrations, and apoptosis levels were detected. Different concentrations of ATRA, autophagy inhibitor (3-MA), andtheir combination were also used to intervene, and relevant protein expressions were detected by Western Blotting.

The combined use of ATRA and tofacitinib inhibited the proliferation and migration of HFLS-RA cells, upregulated IL-6 and IL-10 levels, downregulated IL-17 and VEGF levels, and promoted early apoptosis. Different concentrations ofATRA downregulated Bcl-2, upregulated IκBα, and affected the expression of XIAP, P65, and IKKα/β. The combination of autophagy inhibitor 3-MA and ATRA further upregulated IκBα, downregulated Bcl-2, IKKα/β, and P65.

ATRA may inhibit the activationof the NF-κB pathway by suppressing cell proliferation and migration, downregulating IL-6levels, and inducing apoptosis.

To investigate the association between dietary lycopene intake and cognitive function in adults aged 60 years and older.

Participants were selected from adults aged 60 years and older in the 2011-2014 NHANES database. A logistic regression model was constructed and adjusted for confounding factors such as age and gender to explore the relationship between dietary lycopene intake and cognitive function in older adults.

A total of 2 524 participants were included in this study, with a median dietary lycopene intake of 1 905.25 mcg. After adjusting for age, gender, and other confounding factors, the logistic regression model showed a significant negative correlation between cognitive impairment and dietary lycopene intake in immediate recall test (OR=0.75; 95%CI: 0.58-0.98), delayed recall test (OR=0.78; 95%CI: 0.60-0.99), and digit-symbol substitution test (OR=0.67; 95%CI: 0.49-0.91). Additionally, a significant negative correlation was observed between cognitive impairment and dietary lycopene intake based on composite cognitive scores (OR=0.67; 95% CI: 0.50-0.90). Trend analysis indicated that the risk of cognitive impairment decreased progressively with increasing dietary lycopene intake.

Dietary lycopene intake is negatively correlated with cognitive impairment in older adults. Increased lycopene intake may reduce the risk of cognitive impairment in the elderly.

To explore the mediating pathway mechanisms of depression and life satisfaction in the effects of social activities on quality of life in older adults and to inform the enhancement of quality of life in older adults and the achievement of healthy aging.

A stratified whole group sampling method was used to select 893 older adults aged 60 years and above in Kunming and Xuanwei, Yunnan Province. A face-to-face questionnaire survey was conducted, which included general demographic characteristics, frequency of social activities, life satisfaction, Patient Health Questionnaire (PHQ-9), and EuroQoL Five Dimension Questionnaire (EQ-5D-5L). Univariate and Spearman correlation analyses were performed using SPSS, and Tobit regression (stata) and Structural Equation Model (AMOS) were used to analyze the effects of social activities, depression, and life satisfaction on quality of life as well as to test for the chain mediation effect.

The health utility values of quality of life in the elderly ranged from -0.208 to 1.000, and Spearman correlation analysis showed that the quality of life in the elderly was positively correlated with social activities and life satisfaction (r_s=0.07, 0.32, P<0.05); the quality of life was negatively correlated with the condition of depression (r_s=-0.53, P<0.05); the chain mediation effect analysis showed that depression produced independent mediation effect between social activities and the quality of life of the elderly, with an effect coefficient of 0.029 (95%CI: 0.013-0.050); and depression and life satisfaction had a chain mediation effect between social activities and quality of life with an effect coefficient of 0.003 (95%CI: 0.001-0.006).

Active participation in social activities in older adults can reduce their depressive symptoms, thereby increasing their life satisfaction and consequently improving their quality of life.

To analyze the epidemiological trends of lung cancer in China and the world from 1990 to 2021, and to predict future standardized morbidity and mortality. By assessing the key factors affecting the burden of lung cancer, such as age, time period and birth cohort, the aim is to reveal the risk patterns of morbidity and mortality in different groups, provide a scientific basis for lung cancer prevention and control strategies, and support disease prevention, early intervention and resource allocation optimization.

The data of this study were from the Global Burden of Disease 2021 (GBD 2021) database. Statistical analysis was performed using R 4.4.1 software. The annual percent change (APC) and average annual percent change (AAPC) were calculated by Joinpoint regression model to evaluate the trend of lung cancer incidence and mortality. At the same time, the age-period-cohort model combined with the endogenous factor algorithm (IE) was used to decompose and analyze the age, period and cohort effects, and to evaluate the independent effects of each factor on the risk of morbidity and mortality.

From 1990 to 2021, the average annual standardized incidence of lung cancer in China increased by 0.95%(95%CI: 0.76%-1.13%, P<0.001 ), and the average annual standardized mortality increased by 0.38%(95%CI: 0.13% -0.63%, P=0.003). The global standardized incidence of lung cancer decreased by 0.25%(95%CI: -0.36% -0.13%, P<0.001), and the global standardized mortality decreased by 0.54 %(95%CI: -0.7% -0.37%, P<0.001). It is estimated that the overall standardized incidence of lung cancer in China will decrease to 57.78/100 000 by 2044.It is estimated that the overall standardized incidence of lung cancer in China will decrease to 57.78/100 000 by 2044. The standardized incidence rate of male decreased to 73.59/100 000, and the standardized incidence rate of female increased to 44.80/100 000. The global standardized incidence of lung cancer decreased to 29.82/100 000. During the same period, the overall standardized mortality rate of lung cancer in China decreased to 48.23/100 000. The standardized mortality rate of males decreased to 62.88/100 000, while that of females increased to 36.18/100 000. From 1990 to 2021, the RR value of the period change of lung cancer incidence in China increased year by year, and the RR value of the period change of mortality increased first and then decreased. The cohort effect of lung cancer incidence and mortality also showed a trend of increasing first and then decreasing.

From 1990 to 2021, the incidence and mortality of lung cancer in China continued to rise, while the world showed a downward trend. The incidence and mortality of lung cancer increased with age, and men were significantly higher than women. The period effect increased year by year, and the cohort effect increased first and then decreased. The prediction shows that the incidence and mortality of lung cancer in China and the world will decline as a whole from 2022 to 2044, and the global data is positively correlated with SDI.

To analyze the current status of family resilience in stroke patients and the influencing factors, with further exploration of the pathways between the influencing factors.

A convenience sampling method was used to survey 285 stroke inpatients using the General Information Questionnaire, the Family APGAR Questionnaire (APGAR), the Chinese-version Perceived Stress Scale (CPSS-14), and the Family Resilience Assessment Scale for Stroke Patients. Analyzing the mechanism of influencing factors on family resilience through structural equation modeling.

The family resilience score of stroke patients was (103.98±20.19). The results of the structural equation modeling analysis showed that social demography factors of place of residence had a negative indirect effect on family resilience through family functioning (β=-0.259, P<0.001), and per capita monthly family income had a positive indirect effect on family resilience through perceived stress and family functioning (β=0.373, P<0.001). Disease-related factors such as whether it was a first stroke or not, and the degree of dysfunction had a negative indirect effect on family resilience through perceived stress and family functioning (β=-0.140, P<0.001; β=-0.453, P<0.001). Perceived stress had a negative indirect effect on family resilience through family functioning (β=-0.849, P<0.001) and family functioning had a direct positive effect on family resilience (β=0.966, P<0.001).

The family resilience of stroke patients is at a medium level. Emphasis should be placed on stroke patients who live in rural areas, have a lower economic level, have a first stroke, and have a higher degree of dysfunction. Family resilience can be effectively improved by enhancing family functioning and reducing perceived stress.

To investigate the independent effects and interaction of smoking and shift work on anxiety, depression, and Comorbid Anxiety and Depressive symptoms (CAD) among steelworkers.

Steelworkers undergoing occupational health check-ups from March to September 2017 were studied. Anxiety, depressive symptoms and CAD were assessed using the SAS self-assessment questionnaire and the SDS self-assessment questionnaire. Basic information of workers, demographic characteristics, smoking, and shift data were collected using the Health Assessment Questionnaire. The shift-weighted index (WSI) and smoking index were analyzed for the dose-response relationship between them and the CAD; the WSI were grouped according to the Akaike information crite-rion. Logistic regression analyzed the relationship between smoking, shift work (WSI), and anxiety, depression, and CAD. And to explore the interactive effect of both on CAD.

A total of 3 657 workers were included in this study. The detection rates for anxiety, depression, and CAD were 28.63%, 27.15%, and 22.52%, respectively. WSI > 159 and a smoking index ≥ 200 were independent risk factors for these conditions. Smoking and shift work showed multiplicative and synergistic effects on CAD, with SI, RERI, and AP of 11.86 (8.54-16.47), 28.94 (8.42-49.47), and 0.89 (0.84-0.93), respectively.

Both smoking and shift work increase the risk of anxiety, depression, and their comorbidity. Their combined presence significantly elevates CAD risk in steelworkers. Proper health management measures are recommended to improve mental health.

To explore the relationship between sleep quality and health-related quality of life (HRQoL) among middle-aged and elderly adults with multiple chronic conditions and their family caregivers based on the actor-partner interdependence model, and to further explore the mediating role of depressive symptoms.

A general information questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Geriatric Depression Scale (GDS-15), and the Short Form Health Scale (SF-36) were used to survey middle-aged and elderly adults with multimorbidity and their family caregivers, and data were analyzed using actor-partner interdependence model.

Participants’ sleep quality negatively predicted their HRQoL, and depressive symptoms partially mediated the relationship between sleep quality and HRQoL (the actor effect). In addition, sleep quality in middle-aged and elderly adults with multimorbidity positively predicted caregivers’ depressive symptoms, which in turn negatively predicted their HRQoL (β=-0.25, P<0.05)(the partner effect).

Sleep quality in middle-aged and elderly adults with multimorbidity and caregivers can affect their own HRQoL through depressive symptoms. The patient’s sleep can influence the caregivers’ depressive symptoms and the caregivers’ depressive symptoms can influence the patient’s HRQoL.

To analyze the association between Body Roundness Index (BRI) and to cardiometabolic comorbidities among individuals aged 35-75 years in Zhejiang Province.

Residents aged 35-75 years recruited in the 2022 China National Nutrition and Health Survey (Zhejiang region) were selected as the study population. Statistical analyses were performed using R 4.3.3 and SPSS 30.0. The χ² test and logistic regression were used to evaluate the impact of BRI on cardiometabolic diseases.

The overall prevalence rates of hypertension, diabetes, dyslipidemia, coronary heart disease, stroke, and cardiometabolic comorbidities in Zhejiang residents aged 35-75 years were 41.43%, 15.46%, 40.07%, 1.20%, 0.78%, and 27.99%, respectively. Logistic regression analysis showed that after adjusting for confounders, individuals in the fourth quartile (Q4) of BRI had a higher risk of hypertension (OR=4.10, 95%CI: 3.11-5.38）, diabetes (OR=3.18, 95%CI: 2.20-4.61), dyslipidemia (OR=3.84, 95%CI: 2.95-5.00), coronary heart disease (OR=3.40, 95%CI: 0.74-15.71), stroke (OR=1.10，95%CI: 0.34-3.56) and cardiometabolic comorbidities (OR=5.20, 95%CI: 3.76-7.13) compared with the first quartile (Q1). Female participants (OR=1.43, 95%CI: 1.28-1.60) had a lower risk compared to males (OR=1.70，95%CI: 1.48-1.96). Significant interaction effects of age and smoking on the risk of cardiometabolic comorbidities were observed, with the risk significantly higher in middle-aged adults (35-54 years). In a population with normal BMI, ROC curve analysis indicated that BRI was superior to BMI in predicting the risk of CMM, however, both AUC values were below 0.7, suggesting that the predictive ability remains weak.

Higher BRI levels were positively associated with cardiometabolic comorbidities. To identify high-risk populations for cardiometabolic comorbidities early, targeted management and intervention strategies should be implemented to reduce the burden of cardiometabolic diseases. However, caution is warranted when promoting the use of BRI in public health and clinical practice, as further research is needed to validate its effectiveness.