To measure the workload of primary public health services in rural township health centers, providing empirical evidence for the healthy development of the rural medical and health system.

A multi-stage stratified random sampling method was employed to select 50 township health centers in Guangxi. Data related to primary public health services and primary medical services were collected, and the workload of primary public health services was analyzed using the equivalent method.

The Pearson correlation coefficient between the total equivalent value of primary public health services and the number of permanent residents served was r=0.782, P<0.05; the coefficient of variation for the total equivalent value of different types of primary public health services was F=51.061, P<0.05; the coefficient of variation for the unit equivalent value of resident health records established in different regions was F=2.836, P<0.05, and for the unit equivalent value of health and family planning supervision and coordination services in different regions was F=6.346, P<0.05.

The total value of primary public health services is strongly positively correlated with the number of permanent residents served. There is a significant difference in the total workload of different types of primary public health services. There are differences in the work efficiency of units providing resident health record establishment and health and family planning supervision and coordination services in different regions.

To investigate the current status of tuberculosis(TB) infection prevention and control in primary health care institute in Chongqing.

According to evaluation criterion of the Guideline on tuberculosis infection prevention and control in primary health care institute,the survey was conducted on 146 community health service centers and 506 township health centers in Chongqing. The data of tuberculosis infection prevention and control was collected and analyzed, including organizational management, outpatient settings and workflow, ventilation and disinfection, and personal respiratory protection. SPSS 25.0 soft for descriptive statistical analysis.

In organizational management measures, the proportion of infection control work included in the situation, training and assessment, plan formulation, and system establishment were all above 90%. There were statistically significant difference in the proportion of implementing regular evaluation mechanisms, establishing regular physical examination systems, and equipping tuberculosis infection control related facilities and items in different regions(P<0.05). In the setting and workflow of outpatient clinics, the proportion of online direct reporting (95.71%) and pre-examination triage system (90.18%) was relatively high, the proportion of institutions with separate tuberculosis waiting areas, consultation rooms, and supervision drug rooms/health management rooms (40.34%), as well as prominent signs, notices, directional signs (46.47%), was relatively low. There were statistically significant differences in the proportion of institutions with separate TB waiting areas, consulting rooms and supervision drug rooms/health management rooms in different regions, establishing a pre-screening triage system, and arranging priority for patients with suspected symptoms of TB or suspected TB patients or tuberculosis patients(P<0.05). 82.36% of institutions had good ventilation, and 61.04% of institutions mainly used mobile UV disinfection vehicles for UV disinfection. There was no statistically significant difference in ventilation, disinfection, and personal respiratory protection measures(P>0.05).

The prevention and control of tuberculosis infection in primary health care institute in Chongqing is generally good, but there are still weak links. It is necessary to further strengthen the outpatient setting of primary health care institute, the allocation of health resources in Wuling Mountain Area in southeast Chongqing, establish a regular physical examination system for tuberculosis, improve environmental facilities, enhance the personal protection awareness of medical personnel, and reduce the risk of tuberculosis infection.

To investigate the independent effects and interaction of smoking and shift work on anxiety, depression, and Comorbid Anxiety and Depressive symptoms (CAD) among steelworkers.

Steelworkers undergoing occupational health check-ups from March to September 2017 were studied. Anxiety, depressive symptoms and CAD were assessed using the SAS self-assessment questionnaire and the SDS self-assessment questionnaire. Basic information of workers, demographic characteristics, smoking, and shift data were collected using the Health Assessment Questionnaire. The shift-weighted index (WSI) and smoking index were analyzed for the dose-response relationship between them and the CAD; the WSI were grouped according to the Akaike information crite-rion. Logistic regression analyzed the relationship between smoking, shift work (WSI), and anxiety, depression, and CAD. And to explore the interactive effect of both on CAD.

A total of 3 657 workers were included in this study. The detection rates for anxiety, depression, and CAD were 28.63%, 27.15%, and 22.52%, respectively. WSI > 159 and a smoking index ≥ 200 were independent risk factors for these conditions. Smoking and shift work showed multiplicative and synergistic effects on CAD, with SI, RERI, and AP of 11.86 (8.54-16.47), 28.94 (8.42-49.47), and 0.89 (0.84-0.93), respectively.

Both smoking and shift work increase the risk of anxiety, depression, and their comorbidity. Their combined presence significantly elevates CAD risk in steelworkers. Proper health management measures are recommended to improve mental health.

To understand the current status of medication adherence in patients with HIV/AIDS who have failed antiretroviral therapy and to analyze the mediating effect of anxiety in the influence of family care on medication adherence.

A total of 600 patients with HIV/AIDS who failed antiretroviral therapy were included as study subjects, and data on patients’ demographic characteristics, behavioral characteristics, anxiety, family caring and medication adherence were collected through telephone interviews, and mediation analyses were used to analyze the mediating effect of anxiety on the relationship between family caring and medication adherence.

In this survey 29.33% of the population had family care disorder, 15.8% were in anxiety and 56.0% had good medication adherence. The mean score of medication adherence was moderate at 7.15±1.38. Anxiety in HIV/AIDS antiretroviral treatment failure patients fully mediated the effect of family care on medication adherence. The mediating effect (0.033) (95%CI: 0.017-0.053) accounted for 47.8% of the total effect (0.069) (95%CI: 0.033-0.105).

The percentage of local HIV/AIDS patients with good adherence to medication in patients who have failed antiretroviral therapy is relatively low. By increasing the level of family care and helping patients to alleviate anxiety, medication adherence can be effectively improved and treatment outcomes can be improved.

To investigate the association between UHR and abdominal aortic calcification (AAC) in people aged≥40.

We used data from the 2013—2014 National Health and Nutrition Examination Survey (NHANES), including a total of 3 008 participants. Multiple logistic regression, subgroup analysis and restricted cubic spline (RCS) analysis were used to explore the correlation between UHR and AAC prevalence.

UHR was positively associated with AAC risk in all participants. Compared with the lowest UHR quartile, the highest quartile had a 134.6% increased risk of AAC (OR=2.346, 95%CI: 1.594-3.453). Interaction analysis showed that there was no significant interaction between UHR grouping and gender or age. Gender stratification showed a 213.6% increase in AAC in the Q4 group of females compared with the Q1 group (OR=3.136, 95%CI: 1.884-5.221), while no statistical significance was achieved in males (P=0.113). Age stratification revealed that for those over 60 years old, the risk of AAC in the Q2, Q3, and Q4 groups increased by 118.6% (OR=2.186, 95%CI: 1.140-4.191), 147.4% (OR=2.474, 95%CI: 1.464-4.181), and 347.8% (OR=4.478, 95%CI: 2.580-7.773) compared with the Q1 group, respectively, while in the 40-60 years old group, it did not reach statistical significance (P=0.338). RCS analysis showed that there was a nonlinear relationship between UHR and AAC.

s UHR is an independent risk factor for AAC, and the higher level of UHR, the higher risk of AAC. The association between UHR and AAC is more significant in females and people over 60 years old.

To understand the current situation of self-rated health among older adults, to analyze the influence of good childhood traits on older adults' self-rated health, and to make suggestions for factors with high influence to promote the improvement of health in the whole society.

Using data from the Chinese Family Panel Studies (CFPS), select data for individuals aged≥60, with self-rated health as the dependent variable. Independent variables include age, gender, smoking, drinking, household registration, marital status, education levels, working status, medical insurance, health status before the age of 14, leadership spirit before the age of 14, and adventurous spirit before the age of 14. Employ the χ² test and binary logistic regression to analyze the influencing factors of self-rated health in the elderly. Additionally, use a random forest model to rank the importance of these influencing factors.

Smoking, drinking, higher education levels, being employed, good health status before the age of 14, good leadership spirit before the age of 14, and good adventurous spirit before the age of 14 all have OR values greater than 1 and P<0.05, suggesting they may be protective factors for elderly self-rated health. In contrast, being female and living in rural areas have OR values less than 1 and P<0.05, suggesting they may be risk factors for elderly self-rated health. The top three influencing factors are health status before the age of 14, leadership spirit, and adventurous spirit.

Childhood characteristics have a certain impact on health in old age. To promote the physical health of the elderly, we can improve the physical and mental health of children and cultivate their leadership and adventurous spirit.

To investigate the effects of the combination of all-trans retinoic acidand tofacitinib on human fibroblast-like synoviocytes from rheumatoid arthritis and explorethe mechanisms of autophagy and apoptosis in the NF-κB signalingpathway.

Cells were adaptively cultured and stimulated with TNF-α and IL-1β.Subsequently, HFLS-RA cells were intervened with ATRA, tofacitinib, and their combination.Cell proliferation rate, migration ability, inflammatory cytokine concentrations, and apoptosis levels were detected. Different concentrations of ATRA, autophagy inhibitor (3-MA), andtheir combination were also used to intervene, and relevant protein expressions were detected by Western Blotting.

The combined use of ATRA and tofacitinib inhibited the proliferation and migration of HFLS-RA cells, upregulated IL-6 and IL-10 levels, downregulated IL-17 and VEGF levels, and promoted early apoptosis. Different concentrations ofATRA downregulated Bcl-2, upregulated IκBα, and affected the expression of XIAP, P65, and IKKα/β. The combination of autophagy inhibitor 3-MA and ATRA further upregulated IκBα, downregulated Bcl-2, IKKα/β, and P65.

ATRA may inhibit the activationof the NF-κB pathway by suppressing cell proliferation and migration, downregulating IL-6levels, and inducing apoptosis.

To investigate the association between dietary lycopene intake and cognitive function in adults aged 60 years and older.

Participants were selected from adults aged 60 years and older in the 2011-2014 NHANES database. A logistic regression model was constructed and adjusted for confounding factors such as age and gender to explore the relationship between dietary lycopene intake and cognitive function in older adults.

A total of 2 524 participants were included in this study, with a median dietary lycopene intake of 1 905.25 mcg. After adjusting for age, gender, and other confounding factors, the logistic regression model showed a significant negative correlation between cognitive impairment and dietary lycopene intake in immediate recall test (OR=0.75; 95%CI: 0.58-0.98), delayed recall test (OR=0.78; 95%CI: 0.60-0.99), and digit-symbol substitution test (OR=0.67; 95%CI: 0.49-0.91). Additionally, a significant negative correlation was observed between cognitive impairment and dietary lycopene intake based on composite cognitive scores (OR=0.67; 95% CI: 0.50-0.90). Trend analysis indicated that the risk of cognitive impairment decreased progressively with increasing dietary lycopene intake.

Dietary lycopene intake is negatively correlated with cognitive impairment in older adults. Increased lycopene intake may reduce the risk of cognitive impairment in the elderly.

To analyze the current status of family resilience in stroke patients and the influencing factors, with further exploration of the pathways between the influencing factors.

A convenience sampling method was used to survey 285 stroke inpatients using the General Information Questionnaire, the Family APGAR Questionnaire (APGAR), the Chinese-version Perceived Stress Scale (CPSS-14), and the Family Resilience Assessment Scale for Stroke Patients. Analyzing the mechanism of influencing factors on family resilience through structural equation modeling.

The family resilience score of stroke patients was (103.98±20.19). The results of the structural equation modeling analysis showed that social demography factors of place of residence had a negative indirect effect on family resilience through family functioning (β=-0.259, P<0.001), and per capita monthly family income had a positive indirect effect on family resilience through perceived stress and family functioning (β=0.373, P<0.001). Disease-related factors such as whether it was a first stroke or not, and the degree of dysfunction had a negative indirect effect on family resilience through perceived stress and family functioning (β=-0.140, P<0.001; β=-0.453, P<0.001). Perceived stress had a negative indirect effect on family resilience through family functioning (β=-0.849, P<0.001) and family functioning had a direct positive effect on family resilience (β=0.966, P<0.001).

The family resilience of stroke patients is at a medium level. Emphasis should be placed on stroke patients who live in rural areas, have a lower economic level, have a first stroke, and have a higher degree of dysfunction. Family resilience can be effectively improved by enhancing family functioning and reducing perceived stress.

To explore the mediating pathway mechanisms of depression and life satisfaction in the effects of social activities on quality of life in older adults and to inform the enhancement of quality of life in older adults and the achievement of healthy aging.

A stratified whole group sampling method was used to select 893 older adults aged 60 years and above in Kunming and Xuanwei, Yunnan Province. A face-to-face questionnaire survey was conducted, which included general demographic characteristics, frequency of social activities, life satisfaction, Patient Health Questionnaire (PHQ-9), and EuroQoL Five Dimension Questionnaire (EQ-5D-5L). Univariate and Spearman correlation analyses were performed using SPSS, and Tobit regression (stata) and Structural Equation Model (AMOS) were used to analyze the effects of social activities, depression, and life satisfaction on quality of life as well as to test for the chain mediation effect.

The health utility values of quality of life in the elderly ranged from -0.208 to 1.000, and Spearman correlation analysis showed that the quality of life in the elderly was positively correlated with social activities and life satisfaction (r_s=0.07, 0.32, P<0.05); the quality of life was negatively correlated with the condition of depression (r_s=-0.53, P<0.05); the chain mediation effect analysis showed that depression produced independent mediation effect between social activities and the quality of life of the elderly, with an effect coefficient of 0.029 (95%CI: 0.013-0.050); and depression and life satisfaction had a chain mediation effect between social activities and quality of life with an effect coefficient of 0.003 (95%CI: 0.001-0.006).

Active participation in social activities in older adults can reduce their depressive symptoms, thereby increasing their life satisfaction and consequently improving their quality of life.