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A study on the correlation between dietary lycopene intake and cognitive function in older adults
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Rui LIU1, Xiao-yu WANG2, Fei WANG3, Meng-xue CHEN2, Si-quan ZHOU1, Jing-yuan XIONG1, Guo CHENG2, 4
Modern Preventive Medicine | 2025, 52(10) : 1768 - 1774
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Modern Preventive Medicine | 2025, 52(10): 1768-1774
• Nutrition and Food Hygiene •
A study on the correlation between dietary lycopene intake and cognitive function in older adults
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Rui LIU1, Xiao-yu WANG2, Fei WANG3, Meng-xue CHEN2, Si-quan ZHOU1, Jing-yuan XIONG1, Guo CHENG2, 4
Affiliations
  • West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2025-05-25 doi: 10.20043/j.cnki.MPM.202411565
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Objective

To investigate the association between dietary lycopene intake and cognitive function in adults aged 60 years and older.

Methods

Participants were selected from adults aged 60 years and older in the 2011-2014 NHANES database. A logistic regression model was constructed and adjusted for confounding factors such as age and gender to explore the relationship between dietary lycopene intake and cognitive function in older adults.

Results

A total of 2 524 participants were included in this study, with a median dietary lycopene intake of 1 905.25 mcg. After adjusting for age, gender, and other confounding factors, the logistic regression model showed a significant negative correlation between cognitive impairment and dietary lycopene intake in immediate recall test (OR=0.75; 95%CI: 0.58-0.98), delayed recall test (OR=0.78; 95%CI: 0.60-0.99), and digit-symbol substitution test (OR=0.67; 95%CI: 0.49-0.91). Additionally, a significant negative correlation was observed between cognitive impairment and dietary lycopene intake based on composite cognitive scores (OR=0.67; 95% CI: 0.50-0.90). Trend analysis indicated that the risk of cognitive impairment decreased progressively with increasing dietary lycopene intake.

Conclusion

Dietary lycopene intake is negatively correlated with cognitive impairment in older adults. Increased lycopene intake may reduce the risk of cognitive impairment in the elderly.

Lycopene  /  Cognitive function  /  NHANES  /  Logistic regression models
Rui LIU, Xiao-yu WANG, Fei WANG, Meng-xue CHEN, Si-quan ZHOU, Jing-yuan XIONG, Guo CHENG. A study on the correlation between dietary lycopene intake and cognitive function in older adults[J]. Modern Preventive Medicine, 2025 , 52 (10) : 1768 -1774 . DOI: 10.20043/j.cnki.MPM.202411565
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Year 2025 volume 52 Issue 10
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Article Info
doi: 10.20043/j.cnki.MPM.202411565
  • Receive Date：2024-11-29
  • Online Date：2026-03-18
  • Published：2025-05-25
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  • Received：2024-11-29
Funding
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    West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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