To explore the relationship between multidimensional social deprivation and symptoms of anxiety and depression in the elderly.

In July 2023, a questionnaire survey was conducted with 533 individuals aged 60 and above in a district of Chengdu. Spearman rank correlation analysis was used to assess the correlation between social deprivation and its dimensions with symptoms of anxiety and depression, while multiple binary logistic regression analysis was employed to examine the association between social deprivation and its dimensions with anxiety and depression symptoms.

The detection rates of anxiety and depression symptoms among the study participants were 12.9% and 12.8%, respectively, with a co-occurrence rate of 7.7%. The total score of the social deprivation scale was (45.34±9.30). There were positive correlations between social deprivation and depression symptoms (r=0.544, P<0.001) as well as anxiety symptoms (r=0.391, P<0.001). Social deprivation and its dimensions were identified as risk factors for both anxiety symptoms and depression symptoms, as well as their co-occurrence (P<0.001). Among elderly individuals with chronic diseases, social deprivation and its dimensions were associated with the co-occurrence of anxiety and depression symptoms (P<0.001).

Multidimensional social deprivation is a risk factor for anxiety and depression symptoms in the elderly. Targeted interventions to reduce social deprivation are recommended to improve the mental health of older adults.

The medical service price index is a key reference indicator reflecting changes in medical service prices in a region. This study aims to analyze the variations in medical service prices and subgroup indices across different levels of medical institutions in Leshan city to guide pricing strategy optimization and promote reforms in medical service pricing.

Using a fixed-weight method, the medical service price index (MSPI) for all public medical institutions (36 in total) in Leshan city for the years from 2022 to 2023 was calculated in detail, with data sourced from the medical institution records provided by the Leshan Bureau of Human Resources and Social Security.

Following the reforms in 2023, the overall medical service prices in Leshan city rose, with the total price index reaching 100.38%. Notably, the price indices for medical technical diagnosis, clinical diagnosis, and traditional and ethnic medicine services increased, while the price indices for surgical treatments, acupuncture, and massage therapy saw significant rises. Conversely, the price indices for laboratory tests and medical imaging categories declined, and the comprehensive medical service price index remained unchanged.

The 2023 reforms in Leshan city have effectively optimized the existing structure of medical service prices. Furthermore, the study found that calculating the medical service price index for tertiary medical institutions, which have higher weights, can to some extent reflect the overall medical service price index situation.

To investigate the heterogeneous development trajectories of early depression symptoms in adolescents and their influencing factors.

A cluster sampling method was employed to conduct four follow-up surveys from March 2023 to September 2024, targeting 1 118 seventh-grade students from junior high schools in the Hunan-Hubei-Chongqing-Guizhou border area. Each survey was spaced six months apart, utilizing the Depression Symptoms Scale, Family Support Scale,Peer Relationship Scale, and School Connection Scale. Group-based Trajectory Modeling (GBTM) was used to explore the heterogeneous development trajectories of early depression symptoms in adolescents, while multi-class logistic stepwise regression analysis was performed to identify the relevant factors associated with different latent developmental trajectories.

Four subtypes were identified: “G1: Low Risk-Deterioration Group” (8.27%), “G2: High Risk-Persistent Group”(3.73%), “G3: Low Risk-Stable Group” (78.24%), and “G4: High Risk-Relief Group” (9.76%). Using the G3 group as a reference, the protective factors for the G1 group included being male (OR=0.417, 95%CI: 0.297-0.585), family support (OR=0.870, 95%CI: 0.641-0.923), peer relationships (OR=0.829, 95%CI: 0.740-0.998), and school connection (OR=0.865, 95%CI:0.725-0.906); risk factors included boarding (OR=1.310, 95%CI: 1.154-2.010), being left-behind (OR=2.196, 95%CI: 1.376-3.503), single-parent families (OR=2.247, 95%CI: 1.456-3.468), and low Family Economic Status (FSES) (OR=1.548, 95%CI:1.371-2.451). For the G2 group, protective factors included being male (OR=0.318, 95%CI: 0.263-0.521), family support (OR=0.856, 95%CI: 0.817-0.991), and peer relationships (OR=0.849, 95%CI: 0.711-0.988); risk factors were boarding (OR=1.332,95%CI: 1.022-2.058), being left-behind (OR=1.422, 95%CI: 1.211-3.218), single-parent families (OR=2.953, 95%CI: 1.659-4.256), and low FSES (OR=2.469, 95%CI: 1.188-3.128). For the G4 group, being male (OR=1.350, 95%CI: 1.001-1.513) was identified as a risk factor, while family support (OR=0.892, 95%CI: 0.751-0.943) and school connection (OR=0.846, 95%CI:0.705-0.961) were protective factors.

There is significant group heterogeneity and individual variability in early depression symptoms among adolescents. It is crucial to focus on the “Low Risk-Deterioration Group” and “High Risk-Persistent Group” to enhance the breadth and depth of their interpersonal support networks.

To investigate the distribution characteristics of three endocrine disruptors (EDCs)—nonylphenol (NP),octyl phenol (OP), and bisphenol A (BPA)—in drinking water in the Henan section of the Yellow River Basin and to conduct a health risk assessment.

In October 2023, water samples were collected from 32 urban and rural water plants in the Henan section of the Yellow River Basin, with each plant providing one sample each of source water, treated water, and tap water, totaling 96 samples. The concentrations of EDCs were determined using solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS), and potential health risks were assessed using the risk entropy method.

All three EDCs were detected in the drinking water of the Henan section of the Yellow River Basin, with overall concentrations ranging from Not Detected (ND) to 234.00 ng/L. The detection rates for NP and OP were 100%, while BPA had a detection rate of 36.46%. Among the average values of the three EDCs, NP was found to be greater than OP, which was greater than BPA across different water sample types. Specifically, the average concentration of EDCs followed the order: source water > tap water > treated water. EDCs were commonly found in drinking water across various cities, with NP exhibiting the highest average concentration. Compared to relevant domestic and international studies, the level of EDC contamination in drinking water in this region was considered to be moderate to low. The health risk assessment indicated that the non-carcinogenic health risk values for adults and children ranged from 1.07×10^-5 to 9.34×10^-5, both of which were well below 1, with children’s risks being higher than those for adults.

EDC contamination is prevalent in drinking water in the Henan section of the Yellow River Basin, with low concentration levels and acceptable health risk levels for the population.

To investigate the association between early pregnancy blood routine indicators and fasting blood glucose (FPG) levels with gestational diabetes mellitus (GDM) and their predictive value.

A total of 1 422 early pregnant women enrolled in a prospective dynamic birth cohort at Gansu Provincial Maternal and Child Health Hospital from 2018 to 2022 were included. Baseline data and early pregnancy laboratory indicators were collected, and GDM occurrence was followed up and recorded. Logistic regression was used to analyze the relationship between early pregnancy white blood cell count (WBC),lymphocyte count (LYMPH), hemoglobin (HGB), and FPG levels with the confirmed GDM outcome. Restricted cubic spline (RCS) analysis was conducted to investigate whether there was a nonlinear relationship between WBC, FPG, and GDM. Additionally, subgroups were analyzed based on age, parity, and other factors. Finally, the predictive value of various early pregnancy indicators for GDM was assessed using receiver operating characteristic (ROC) curves.

Among the 1 422 early pregnant women, 154 developed GDM in mid-pregnancy. After adjusting for covariates such as age, pre-pregnancy BMI, and parity, logistic regression analysis revealed that the risk of developing GDM for the highest quartile levels of WBC, LYMPH, HGB, and FPG was 1.774 times (95%CI: 1.088-2.893), 1.712 times (95%CI: 1.035-2.833), 1.597 times (95%CI: 1.004-2.555), and 6.459 times (95%CI: 3.612-11.151) that of the lowest quartile group, respectively, with all differences being statistically significant (P<0.05). RCS analysis indicated a positive linear dose-response relationship between early pregnancy WBC, FPG, and the risk of GDM. In subgroup analysis, overweight and obese women showed an increased risk of GDM with elevated early pregnancy WBC (OR=1.212,95%CI: 1.106-1.445) and FPG (OR=6.758, 95%CI: 3.407-14.989). The combination of early pregnancy WBC, FPG, HGB, age, and pre-pregnancy BMI provided the best predictive value for GDM (AUC=0.736, 95%CI: 0.695-0.776).

Clinical practitioners should focus on early pregnancy WBC and FPG levels, as well as the conditions of advanced maternal age and overweight/obesity, to implement timely health interventions for primary prevention of GDM.

To analyze the current status of perceived HIV/AIDS-related stress among elderly individuals living with HIV/AIDS (PLWHA) and its influencing factors, and to explore the mediating role of psychological resilience between social support and HIV/AIDS-related stress.

A convenience sampling method was employed to include 405 elderly PLWHA from the Infectious Diseases and Immunology Department of Changsha Infectious Disease Hospital between January and February 2024. The on-site questionnaire included the Social Support Rating Scale (SSRS), the 10-item Connor-Davidson Resilience Scale (CD-RISC-10), the Chinese HIV/AIDS Stress Scale (CSS-HIV), as well as demographic and disease characteristic information. Descriptive analysis, univariate analysis, and multiple stepwise linear regression were used to analyze the current status and influencing factors of HIV/AIDS-related stress; mediation analysis was conducted to explore the mediating effect of psychological resilience on HIV/AIDS-related stress.

The total score for HIV/AIDS-related stress among elderly PLWHA was 24.84±14.01, with emotional stress scoring 5.91±5.98,social stress 14.23±6.21, and instrumental stress 4.71±4.74. Factors influencing HIV/AIDS-related stress included being retired or engaged in farming, comorbidities, levels of social support, and psychological resilience (P<0.05). Psychological resilience showed a partial mediating effect in the relationship between social support and HIV/AIDS-related stress, accounting for 40.81% of the mediation effect.

Psychological resilience partially mediates the impact of social support on HIV/AIDS-related stress among elderly PLWHA. Interventions aimed at improving the status of social support and enhancing the psychological resilience of patients may help alleviate HIV/AIDS-related stress, thereby reducing their psychological burden and suffering.

To describe the epidemic characteristics of pertussis in Jiangsu Province from 2011 to 2023 and to explore the feasibility of using the Autoregressive Integrated Moving Average (ARIMA) model for predicting pertussis incidence in the province.

Epidemiological characteristics of pertussis cases collected for this study were analyzed. Data from January 2011 to June 2023 were used as the training set to construct the ARIMA model, which was then utilized to predict the incidence trend of pertussis from July 2023 to December 2024, thereby evaluating the model’s predictive performance.

A total of 1 970 pertussis cases were reported in Jiangsu Province from 2011 to 2023, with an annual incidence rate of 0.19 per 100 000. The number of reported male cases exceeded that of female cases, yielding a sex ratio of 1.08:1. Most cases occurred in infants under one year of age (52.2%, 1 049/1 970), with 83.5% of these infants being under six months old (876/1 049). Pertussis exhibited a seasonal peak during spring and summer, with the highest incidence observed in April. The ARIMA (1,1,3) (0,1,2)₁₂ model was identified as the optimal predictive model for this study, showing a close alignment between the model-fitted incidence trend from 2011 to 2023 and the actual incidence trend. Additionally, the actual monthly incidence from July to December 2023 fell within the 95% confidence interval of the predicted values.

This model effectively fits the incidence of pertussis in Jiangsu Province and holds practical value for short-term prediction and analysis of pertussis in the region.

To investigate the impact of omorbidities on sleep duration in middle-aged and elderly individuals in China.

This study was a cross-sectional analysis using data from the 2020 China health and retirement longitudinal study database to examine the relationship between comorbidities and sleep duration. Directed acyclic graphs were used to identify potential confounding factors. Overlap weighting and linear regression with double confounding adjustment were applied to minimize group differences and make inter-group comparisons more akin to a randomized trial. The impact of comorbidities on sleep duration was explored through linear regression, and sensitivity analyses were conducted to verify the robustness of the results, with subgroup analyses performed.

A total of 17 010 participants aged 45 years and older were included in the analysis. The results indicated that comorbidities affected individual sleep duration. Individuals with multimorbidity had a sleep duration that was approximately 0.12 hours shorter compared with those without multimorbidity (B=-0.121 4, P<0.05). Sensitivity analysis showed an E-value of 1.48. Furthermore, this impact was more pronounced in females (B=-0.159 4, P<0.05) and in the middle-aged group (45-60 years) (B=-0.225 8, P<0.05).

There is a difference in sleep duration between middle-aged and elderly individuals with chronic disease comorbidity, with a more pronounced effect observed in females and the middle-aged group. The study utilizes overlap weighting, demonstrating the significant impact of comorbidities on sleep duration, providing empirical evidence for improving sleep conditions in this population.

To develop an evaluation index system for public health emergency response capacity of county-level centers for Disease control and Prevention (CDC) to promote the construction of public health emergency response system and improve the emergency response capacity of county-level CDC in China.

The index system framework was developed based on a literature review and group discussions. The Delphi method was applied to select the evaluation indicators through two rounds of expert consultation involving 26 experts, and the weights of the indicators were determined using the Analytic Hierarchy Process (AHP).

The system included 6 primary indicators, 21 secondary indicators, and 69 tertiary indicators. The weights of each indicator were calculated using the Analytic Hierarchy Process (AHP). The weight of first-level indicators from high to low were emergency response capacity (0.212), emergency system construction (0.199), emergency support capacity (0.175), monitoring and early warning capacity (0.170), emergency team (0.161), information communication and departmental collaboration (0.083). Among the second-level indicators, the weights of training exercise (0.490), early warning and prediction (0.490), and emergency fund guarantee (0.490) were in the top three. The consistency ratio (CR) values for the first-level, second-level, and third-level indicators were all below 0.1, which met the standard requirements of consistency test, and the weight division of indicators was reasonable.

This study provides indicator guidance for improving the emergency response capacity of county CDC, and promote the construction of public health emergency response system in China and the improvement of emergency response capacity of county CDC.

To analyze the molecular transmission network characteristics and drug resistance of newly reported human immunodeficiency virus type 1 (HIV-1) infected individuals in Guiyang City, to provide a basis for epidemic trends and preventive and control measures.

Blood samples and demographic information of newly reported HIV-1 infected individuals who did not receive antiviral therapy in Guiyang City from 2021 to 2023 were collected. The obtained pol region gene sequences were uploaded to the Stanford University HIV drug resistance database for genotype and drug resistance analysis, and molecular transmission network was constructed based on the optimal gene distance (d=1.5%) and analyzed for factors influencing entry into the network.

A total of 171 samples were collected, and 123 (71.93%) were successfully amplified to obtain valid sequences. Six genotypes were found, mainly CRF07_BC (54.5%, 67/123) and CRF01_AE (24.4%, 30/123). A total of 38 sequences were integrated into the network, with an integration rate of 30.89%. 13 molecular clusters were formed, and the number of cases in the clusters ranged from 2 to 9. Multivariate Logistic regression results showed that heterosexual transmission, CRF07_BC and CRF01_AE were more likely to enter the network(P<0.05). CRF07_BC in Chongqing, Guangxi, Yunnan and Guiyang had cross-regional transmission. The drug resistance rate of 123 samples before treatment was 17.07% (21/123), the drug resistance rates were 7.32% for non-nucleoside reverse transcriptase inhibitors (NNRTIs), 3.25% for nucleoside reverse transcriptase inhibitors (NRTIs), 3.25% for protease inhibitors (PIs), and four samples showed dual drug resistance.

The genotypes of newly reported HIV-1 infected individuals in Guiyang were mainly CRF07_BC and CRF01_AE. CRF07_BC is closely related to Chongqing and Guangxi. The drug resistance rate of HIV-1 before treatment was high. In the future, we should continue to build molecular transmission networks for long-term monitoring of the area, cooperate with neighboring provinces and cities to take effective AIDS prevention and control measures to further curb the transmission and spread of the virus.