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To explore the association between overt proteinuria (OP) and moderately reduced estimated glomerular filtration rate (MG) in relation to the incidence of coronary artery disease (CAD).
The study targeted elderly individuals (aged ≥60 years) who completed at least two national basic public health service health examinations at a community health service center in Chengdu from 2017 to 2022. A total of 4 316 subjects were categorized into four groups based on the presence or absence of OP and MG: no OP no MG (NP[MG-]), OP no MG (OP[MG-]), no OP with MG (NP[MG+]),and OP with MG (OP[MG+]). An intrinsic time-dependent Cox analysis was conducted to evaluate the association of estimated glomerular filtration rate and proteinuria, individually or in combination, with the risk of CAD.
The study included 4 316 subjects with a median follow-up time of 6.25 years, during which 419 developed new cases of CAD. The results indicated that compared to the group with both indicators negative, the risk of CAD increased by 15% (HR=1.15, 95% CI: 0.88-1.41) for those with moderately reduced estimated glomerular filtration rate (MG+), by 14% (HR=1.14, 95% CI: 0.76-1.51) for those with overt proteinuria (OP), and by 93% (HR=1.93, 95% CI: 1.50-2.37) for those with both indicators positive (OP[MG+]). The combined use of both indicators demonstrated a superior discriminatory effect on CAD risk compared to the use of either indicator alone.
Routine screening for estimated glomerular filtration rate and albuminuria in the elderly population is recommended, as the combined assessment of both indicators is more effective in identifying individuals at high risk for coronary artery disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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