To investigate and analyze the situation of hospital acquired infection in surgical ward of Guizhou Province in 2022, and to provide direction and method for improving the prevention and control of hospital acquired infection.

The prevalence of hospital acquired infection in surgical wards of 186 medical institutions in the province from July to December 2022 was investigated by means of a cross-sectional survey and bedside survey combined with inpatient records.

A total of 27 046 patients were investigated, and 504 cases of hospital acquired infection occurred. The prevalence rate of hospital acquired infection was 1.86%, neurosurgery(4.43%) and cardio-thoracic surgery(3.25%) were the highest, and the difference of infection rate among different surgical systems was statistically significant(χ²=157.980, P<0.001). The main site of hospital acquired infection was respiratory tract(0.99%), surgical site(0.50%), skin and soft tissue(0.24%), and the incidence rate of different infection sites was statistically significant(P<0.05). The prevalence rate of hospital acquired infection in Class I incision was 3.42%. The highest utilization rate of antibiotics was 40.72% in cardio-thoracic surgery(13.01%) and neurosurgery(11.64%). The hospital acquired infection rate of Class I incision in different departments was significantly different(χ²=186.607, P<0.001). The main purpose of medication in surgical ward was treatment(26.10%), and the rate of pre-medication examination in surgical ward was 33.41% for single medication(36.06%).

The incidence rate of hospital acquired infection in surgical ward shows a decreasing trend. Cardio-thoracic surgery and neurosurgery are still the most common departments causing hospital acquired infection of respiratory tract and incision-like surgical site infection.

To examine the association between time to first cigarette (TTFC) after waking and hypertension in males.

The baseline data of 587 male current smokers in Rongchang district were collected from the China Multi-Ethnic Cohort(CMEC) Study in Rongchang. The association between TTFC after waking and hypertension was conducted by multivariate logistic regression.

TTFC ≤5 minutes, 6-30 minutes, 31-60 minutes and > 60 minutes accounted for 34.24%, 26.75%, 16.70% and 22.31%. The prevalence of hypertension among 587 participants were 59.20%, 40.76%, 35.71%, 29.01%. Compared with TTFC>60 min after waking, TTFC<5min(OR=3.691, 95% CI: 2.176-6.259) and 6-30 min(OR=1.876, 95% CI: 1.236-2.911) were risk factors of hypertension after adjusting for confounding factors.

The short TTFC after waking is associated with a higher risk of hypertension. It is helpful to evaluate the risk of hypertension and make targeted smoking cessation plan according to TTFC.

To investigating the impact of Financial Burden on Health-Related Quality of Life in elderly patients with Chronic Comorbid Conditions and its mechanisms.

A convenience sample of 493 chronic comorbid patients was extracted from two community health service centers in Yanji City. General information was collected using a questionnaire, and the Patient Experiences with Primary Care (ASPC) scale, Comprehensive Score of Financial Burden (COST), Herth Hope Scale, and SF-36 Health Survey were utilized for the investigation.Univariate analysis, partial correlation analysis, and testing a moderated mediation model was conducted.

(1) Financial Burden significantly predicted HRQoL(β=0.32, 95% CI:0.24-0.40, P<0.001);(2) Hope level partially mediated the relationship between Financial Burden and HRQoL (β=0.12, 95% CI:0.08-0.16, P<0.001), accounting for 37% of the total effect; (3) The direct predictive effect of Financial Burden on health-related quality of life (β=0.07, 95% CI:0.01-0.14，P<0.05) and the mediating role of hope in their relationship(β=0.13，95% CI：0.05-0.21，P<0.01) were both moderated by the core features of comprehensive primary care.

This study reveals the mechanism by which Financial Burden impacts HRQoL in elderly patients with chronic comorbidities. The findings emphasize the importance of enhancing economic support and hope levels for this patient group and highlight the role of comprehensive primary care function in mitigating the adverse effects of Financial Burden on HRQoL. These insights contribute to providing more comprehensive and effective medical services to patients with chronic comorbidities, alleviating the impact of Financial Burden, and enhancing their overall quality of life.

To realize rapid qualitative and quantitative detection of 13 triterpenoids in Wolfiporia cocos from Yunnan by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry.

Triterpenoids in Wolfiporia cocos were extracted by ultrasonic extraction (methanol). The separation was carried on an ACQUITY UPLC © HSS C18 column (2.1 mm×50mm, 1.7μm) with, 10 mmol/L ammonium formate-0.1% formic acid aqueous solution and acetonitrile as mobile phase. The gradient elution flow rate was 0.5ml/min, with the column temperature of 30℃. Negative ion multiple reaction monitoring mode was used for detection. Qualitative and quantitative analysis using secondary mass spectrometry and accurate molecular weight.

13 triterpenoids in Wolfiporia cocos were good with in the linear ranges (r≥0.99). The spiked recoveries were from 80.35% to 116.92%, with relative standard deviations of 1.88% to 9.7%. 13 triterpenoids were detected in Wolfiporia cocos samples, and the total contents were between 79 433-85 900 mg/kg.

The method is simple, accurate, efficient and sensitive, and it is suitable for the qualitative and quantitative detection of 13 triterpenoids in Wolfiporia cocos.

To establish a model for predicting the risk of visual disability in patients with diabetic retinopathy and verify it externally.

A total of 383 DR Patients who received ophthalmology treatment in a tertiary eye hospital in Anhui Province from April to December 2022 were conveniently selected as the modeling group to construct a visual disability risk prediction model and test the prediction effect. It was convenient to select 165 patients with diabetic retinopathy from January 2023 to April 2023 in this hospital as the verification group for external verification.

The incidence of visual disability in the modeling group was 51.70%. Gender, living style, whether suffering from other chronic diseases, regular revisit, DR Stage, number of diseased eyes, intraocular pressure value and family history of diabetes were the influencing factors(P< 0.05). The final regression equation was as follows: Logit(P) =－8.825+0.797×sex－0.874×residence style+1.504×whether you have other chronic diseases－0.871×whether you have regular follow－up visits +0.743×DR Stage+1.250×number of diseased eyes+0.166×intraocular pressure value +0.920×family history of diabetes. The Hosmer-Lemeshow test of the modeling group showed that x²=12.861, P=0.117, area under ROC curve was 0.838, 95% CI(0.795, 0.882), sensitivity was 0.737, specificity was 0.809. The Hosmer-Lemeshow test of the verification group showed that x²=15.141, P=0.056, area under ROC curve was 0.785, 95%CI was 0.704 - 0.866, sensitivity was 0.795, specificity was 0.727, accuracy was 75.76%.

The prediction effect of this model is good, and it can provide reference for clinical evaluation of the risk of visual disability in diabetic retinopathy patients.

To construct the Bayesian network model of H-type hypertension in middle-aged and elderly people, and to explore the influencing factors of H-type hypertension and the network relationship between factors, and the strength of each influencing factor on H-type hypertension.

A total of 1 119 middle-aged and elderly people who underwent physical examination in the hospital health management center from May 2022 to April 2023 were selected as the research objects and relevant data were collected. Univariate logistic regression analysis and multivariate logistic regression analysis models were used for preliminary screening of variables, “bnlearn” Bayesian network software package was used for model construction, and Netica software was used for model inference.

Logistic regression analysis model was used to screen the variables, such as age, gender, education level, smoking, drinking, body mass index(BMI), fasting blood glucose, etc. FBG, total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol((HDL-C), low density lipoprotein cholesterol(LDL-C) and uric acid(UA) were included in the Bayesian network model. A Bayesian network model of H-type hypertension related factors in middle-aged and elderly people with 13 nodes and 16 directed edges was constructed by using 12 selected variables as network nodes. Age, FBG, TG, HDL-C and BMI were directly related to H-type hypertension, while gender, smoking, drinking, educational level, TC, LDL-C and UA were indirectly related to H-type hypertension. When the age was≥60years old, FBG≥6.85 mmol/L, BMI≥24.83 kg/m², HDL-C≥1.02 mmol/L, TG<1.6 mmol/L, the risk of H-type hypertension reached 0.565.

The Bayesian network model reveals the direct and indirect factors and correlation strength of H-type hypertension in middle-aged and elderly people, clarifies the complex network relationship between factors, and provides a scientific basis for early prevention of H-type hypertension in middle-aged and elderly people.

To understand the concentration of formaldehyde pollution in indoor air of four types of public places in Shijiazhuang City, and to assess the chronic non-carcinogenic and carcinogenic risks of employees in various types of places.

Using the monitoring data of health hazards in public places, we analyzed the concentration levels of formaldehyde in the indoor air of swimming pools, barber stores, beauty stores, and hotels in Shijiazhuang City in 2021-2022, and evaluated the chronic non-cancer and cancer risks of formaldehyde for employees in the above four types of public places by adopting the classic "four-step" health risk assessment model of the U.S. Environmental Protection Agency(US EPA).

From 2021 to 2022, a total of 169 swimming pools, barber stores, beauty stores and hotels were randomly selected, with a total sample size of 485 formaldehyde tests, and the overall pass rate was 91.34%. The pass rate of formaldehyde concentration in the indoor air of swimming pools in the above four types of public places was 100%(161/161), 93.10%(27/29) for barber stores, 90.09%(20/22) for beauty stores and 86.08%(235/273) for guesthouses(hotels), with statistically significant differences(χ²=24.931, P<0.001); the mean value of the HQ of the chronic non-carcinogenic effect of formaldehyde for practitioners in swimming pools was less than 1, and that for practitioners in the other three types of public places was greater than 1, and swimming pools, Hairdressers, beauty stores, and hotels, the cancer risk values of formaldehyde for employees were 1.90×10^-5, 8.19×10^-5, 1.13×10^-4, and 5.63×10^-5, respectively, which were higher than the limit value(1×10^-6) set by the U.S. Environmental Protection Agency(US EPA).

Exposure to formaldehyde in the indoor air of swimming pools in Shijiazhuang City doesn’t exceed the threshold for adverse reactions, and the chronic non-carcinogenic risk of formaldehyde for practitioners in this type of venue is low.There was a certain amount of chronic non-carcinogenic and carcinogenic risk for practitioners in barber stores, beauty stores, and guesthouses, and the risk value of formaldehyde for practitioners in the beauty category of venues is the highest, and it should be analyzed in further studies.

To evaluate the reliability and validity of the Chinese version of the Social Connectedness Scale-Revised(SCS-R) in order to provide correct way of its application among psychiatric patients.

A convenience sampling method was employed to select 345 patients with different types of mental disorders from K Hospital in Shenzhen. The patients’ general demographic information and disease conditions were collected, and Chinese version SCS-R was used to assess their social connectedness status. Cronbach α and split-half reliability were calculated to evaluate the reliability of SCS-R. Structural, convergent, discriminant, and discriminative validity were performed to measure the validity. The sample was randomly divided into half, exploratory factor analysis was used to explore the internal dimension of SCS-R, and confirmatory factor analysis was used to compare the scale structure explored and compared with the other three existing scale structures.

The Cronbach α coefficients for the total scale, social connectedness, non-social connectedness, and integration sense sub scales were 0.922, 0.904, 0.887 and 0.740, respectively. The split-half coefficients were 0.908, 0.918, 0.875 and 0.760, respectively. Exploratory factor analysis identified a three-factor structure, and confirmatory factor analysis showed that the scale structure developed in this study had a better fit than the other three and could explain 62.253% of the total variance. Both convergent validity and discriminant validity had success rates of calibration experiment as 100%. The correlation coefficients indicated good discriminative validity for the three dimensions of the scale.

The Chinese version of the SCS-R scale has shown good reliability and validity among psychiatric patients, making it suitable for evaluating the social connectedness of this population.

To evaluate the association between abnormal renal function indicators (SUA and eGFR) and non-alcoholic fatty liver disease (NAFLD).

Based on 2017-2021 Beijing Health Management Cohort, the cross-lagged panel model was used to investigate the causal temporal relationship between abnormal SUA and glomerular filtration rate and the onset of NAFLD.

(1) Increased SUA and NAFLD: ① Path coefficients from baseline SUA to follow-up HSI were statistically significant in both the general population (β=0.018, 95% CI: 0.003-0.032) and BMI≥24 kg/m² (β=0.051, 95% CI: 0.032-0.070), but not the other way around. ② Path coefficients from baseline SUA to follow-up HSI (β=0.048, 95% CI: 0.028-0.068) and baseline HSI to follow-up SUA (β=0.023, 95% CI: 0.005-0.041) were statistically significant in BMI<24 kg/m². (2) eGFR abnormalities and NAFLD: ① Path coefficients from baseline HSI to follow-up eGFR were statistically significant in both the general population (β=0.024, 95% CI: 0.012-0.036) and BMI≥24 kg/m² population (β=0.035, 95% CI: 0.018-0.052), but not the other way around. ② In BMI<24 kg/m², the path coefficients from baseline eGFR to follow-up HSI and baseline HSI to follow-up eGFR were not statistically significant.

In the general population and BMI≥24 kg/m², the abnormal SUA is earlier than the incidence of NAFLD, and the incidence of NAFLD may affect the subsequent glomerular filtration rate. In people with normal BMI, the onset of NAFLD is associated with elevated SUA, but not with abnormal glomerular filtration rate.

To explore the relationship among self-perceived burden, family resilience and quality of life in patients with ovarian cancer, and to analyze the potential role of family resilience between self-perceived burden and quality of life.

Ovarian cancer patients hospitalized in the oncology departments of two tertiary hospitals in Sichuan Province from May 2022 to January 2023 were selected as the research subjects, and the general information questionnaire, family resilience assessment scale (FRAS), self-perceived burden scale of cancer patients (SPBS-CP), and ovarian cancer quality of life scale (FACT-O) were used to conduct questionnaire surveys. SPSS 22.0 was used for descriptive analysis, correlation analysis and multiple linear regression analysis. PROCESS 3.4 was used to analyze the mediating effect of family resilience between self-perceived burden and quality of life, and the Bootstrap method was used to test the mediating effect.

The family resilience score of ovarian cancer patients was (140.61±15.82), self-perceived burden was (59.46±19.95), and quality of life was (91.52±32.01). There was a positive correlation between family resilience and quality of life in patients with ovarian cancer (r=0.464, P<0.01), and the self-perceived burden was negatively correlated with family resilience and quality of life (r=-0.385, -0.439, P<0.01). Family resilience had a partial mediating effect between ovarian cancer patients’ self-perceived burden and quality of life, and the mediating effect accounted for 30.35% of the total effect.

The self-perceived burden of ovarian cancer patients is at a moderate level, family resilience is at a lower middle level, and the quality of life needs to be improved. It is recommended that healthcare professionals improve the quality of life by enhancing family resilience and reducing the burden of self-perception through health education methods such as enhancing family support, establishing coping beliefs, and promoting family communication.