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To evaluate the association between abnormal renal function indicators (SUA and eGFR) and non-alcoholic fatty liver disease (NAFLD).
Based on 2017-2021 Beijing Health Management Cohort, the cross-lagged panel model was used to investigate the causal temporal relationship between abnormal SUA and glomerular filtration rate and the onset of NAFLD.
(1) Increased SUA and NAFLD: ① Path coefficients from baseline SUA to follow-up HSI were statistically significant in both the general population (β=0.018, 95% CI: 0.003-0.032) and BMI≥24 kg/m2 (β=0.051, 95% CI: 0.032-0.070), but not the other way around. ② Path coefficients from baseline SUA to follow-up HSI (β=0.048, 95% CI: 0.028-0.068) and baseline HSI to follow-up SUA (β=0.023, 95% CI: 0.005-0.041) were statistically significant in BMI<24 kg/m2. (2) eGFR abnormalities and NAFLD: ① Path coefficients from baseline HSI to follow-up eGFR were statistically significant in both the general population (β=0.024, 95% CI: 0.012-0.036) and BMI≥24 kg/m2 population (β=0.035, 95% CI: 0.018-0.052), but not the other way around. ② In BMI<24 kg/m2, the path coefficients from baseline eGFR to follow-up HSI and baseline HSI to follow-up eGFR were not statistically significant.
In the general population and BMI≥24 kg/m2, the abnormal SUA is earlier than the incidence of NAFLD, and the incidence of NAFLD may affect the subsequent glomerular filtration rate. In people with normal BMI, the onset of NAFLD is associated with elevated SUA, but not with abnormal glomerular filtration rate.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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