To analyze the disease characteristics, comorbidity patterns, and healthcare burden of hospitalized patients with hypertension and comorbidities, providing evidence for optimizing hypertension comorbidity management.

A retrospective analysis was conducted on 810 747 hospitalized patients with hypertension and comorbidities from all general hospitals in Zhanjiang, Guangdong, between 2016 and 2022. Systematic cluster analysis was used to generate a dendrogram and identify comorbidity patterns. Inter-group comparisons were performed to analyze hospitalization costs across different patterns.

From 2016 to 2022, the number of hospitalized hypertensive patients with comorbidities showed an overall increasing trend, with a higher and rising proportion of males. The age distribution shifted toward older populations, with patients aged ≥85 years increasing annually. The top five most common comorbidities were atherosclerotic heart disease, cerebral infarction, type 2 diabetes, lipoprotein metabolism disorders, and chronic gastritis. Cluster analysis identified eight comorbidity patterns: cardiovascular disease, cerebrovascular-metabolic disease,hepatic-renal disease, spinal-digestive disease, cerebral ischemia, senile cataract, dizziness-vertigo, and stroke. The senile cataract group incurred the highest total hospitalization costs(4 705.6,P<0.001). Among multi-comorbidity patterns, the hepatorenal disease group exhibited the highest total hospitalization costs(4 527.8), and the cardiovascular disease group had significantly higher Western medication and material expenses (P<0.001).

Hospitalized hypertensive patients with comorbidities are increasing in number and age. Prevention efforts should prioritize cardiovascular, metabolic, and digestive comorbidities. Eight distinct comorbidity patterns were identified, with senile cataract and hepatic-renal disease patients representing key populations for cost containment.

To investigate the variations in the species composition and functional attributes of intestinal microbiota in individuals suffering from metabolic fatty liver disease in Tibetan regions, and to provide a research basis for the prevention and treatment of metabolic fatty liver disease in Tibetan population.

Based on the follow-up survey data of the Southwest region natural population in Lhasa, a total of 103 subjects were included for follow-up analysis according to the guidelines for the prevention and treatment of metabolic-associated (non-alcoholic) fatty liver disease (2024 edition). The demographic information, anthropometric indicators, blood biochemical indicators, and fecal samples were collected, and DNA was extracted for metagenomic sequencing analysis. The composition of intestinal flora in patients with metabolic fatty liver disease and healthy people was compared by bioinformatics methods. The metabolic pathways and their coding genes were analyzed by genome encyclopedia (KEGG) . Linear discriminant analysis was used to screen the differential flora, and Spearman rank correlation and linear regression were used to explore its relationship with related phenotypes.

The alpha diversity of patients with metabolic fatty liver was significantly reduced (W=858, P<0.001). The abundance of Bacteroidetes in the intestinal tract of patients with metabolic fatty liver was significantly lower than that of normal people (H=8.990, P=0.003). These include Bacteroides uniformis, Bacteroides fragilis, Bacteroides ovatus, and the butyrate-producing Porphyromonas Phocaeicola salanitronis (LDA>3, P<0.050). Fusobacterium varium (LDA=2.16, P=0.024) was significantly enriched in MAFLD population and positively correlated with multiple disease phenotypes. Glucose and lipid metabolism-related pathways and KO genes were also significantly enriched in patients with metabolic fatty liver.

The intestinal microbiota and metabolic function of Tibetan patients with metabolic fatty liver disease are significantly changed, and the disruption of intestinal flora balance may also have a close association with the onset and progression of metabolic fatty liver disease among Tibetan patients.

To investigate the dose-response effect of green elements and duration of green exercise on executive function among college students.

Using a mixed experimental design, 90 physically active college students were assigned to greener and less green environment exercise groups and 10-, 20-, and 30-minute exercise durations according to their physical activity level. All subjects completed a moderate-intensity two-legged jump-rope workout, during which heart rate was monitored using a Polar RS800. Inhibitory control, working memory and cognitive flexibility were tested before and after the exercise.

(1) The inhibitory control as well as working memory in the greener group was significantly better than that of less-green environment at the end of the exercise; (2) inhibitory control, working memory, and cognitive flexibility were significantly better in 20 versus 30 minutes condition than in 10 minutes, but 20 versus 30 minutes was not significant.

Green environments and long duration exercise are more conducive to improving executive function, but there is no significant synergistic effect of green environments and exercise duration.

To investigate the effect of depressive symptoms on the risk of developing type 2 diabetes mellitus in middle-aged and elderly people in China.

Based on the data from the China Health and Retirement Longitudinal Study (CHARLS) 2011 and 2018, 9 697 middle-aged and elderly people aged 45 years or older were included as study subjects. Chained equations were used to perform g-formula analysis after multiple interpolation of missing values of covariates, and stratified analyses were performed to explore the association between depressive symptoms and the risk of developing type 2 diabetes mellitus with respect to age and gender.

The results of the analysis after multiple interpolation of covariates and adjustment for confounding showedthat the mean risk of developing type 2 diabetes mellitus in study participants with depressive symptoms which was 1.3 times higher than that of those without depressive symptoms ［RR(95% CI):1.37(1.15-1.62)］, with a mean hazard difference of 0.02. Those with mild depressive symptoms had a mean risk of type 2 diabetes mellitus of 1.27 times higher than that of those without depressive symptoms ［RR(95% CI):1.27(1.07-1.52)］, with a mean difference of 0.01; those with severe depressive symptoms had a mean risk of developing type 2 diabetes mellitus that was 2.22 times higher than that of those who were not depressed ［RR(95% CI):2.22(1.64-3.00)］; the mean difference was 0.06.

Depressive symptoms and the risk of type 2 diabetes mellitus were significantly associated with the risk of developing type 2 diabetes mellitus among middle-aged and elderly people in China. Associated with the risk of developing type 2 diabetes, the risk of developing the disease increased with the severity of depressive symptoms.

To analyze the characteristics and issues of Jiangsu’s healthcare system policies and provide optimization insights.

Using Rothwell and Zegveld’s policy tool classification, a three-dimensional framework (policy tools, development process, policy goals) was constructed to quantify 70 policy texts from the 13th and 14th Five-Year Plan periods.

Policy tools: environmental-type dominated (58.83%), followed by supply-type (34.78%), demand-type (6.38%) was minimal. Policy process: implementation (52.27%) and planning (40.24%) prevailed, while supervision (6.48%) and evaluation (1.02%) were underdeveloped. Policy goals: advancing public hospital quality (44.11%) was prioritized, whereas strengthening medical insurance (9.03%) lagged.

Structural imbalance in policy tools, fragmented policy processes, and divergent goals were observed. Recommendations: optimize tool allocation by increasing demand-type tools, integrate policy processes, and align goals systematically.

To understand the aging trend and some characteristics of people living with HIV who first received antiretroviral therapy (ART) in Guizhou province from 2005 to 2022, and to provide reference for the development of follow-up management measures for the elderly population.

The baseline characteristics of HIV/AIDS patients receiving ART in Guizhou province from 2005 to 2022 were collected from the National HIV/AIDS Antiretroviral Treatment Information System. Joinpoint regression was used to analyze the trends of baseline gender, age, transmission route, time from diagnosis to treatment initiation, and CD4+T lymphocyte (CD4+) level.

From 2005 to 2022, a total of 29 366 elderly patients (aged≥50 years) in Guizhou Province received ART treatment for the first time. The proportion of elderly men receiving ART showed a decreasing trend from 2007 to 2022 (APC=-1.30%, P<0.001). The proportion of elderly patients with married status and having a spouse decreased (APC=-2.44%, P<0.001). The proportion of elderly patients with infection through heterosexual transmission reached a turning point in 2007, and it showed a rapid upward trend from 2005 to 2007 (APC=264.70%, P<0.001). The proportion of elderly patients with a one-to-two-year time interval from diagnosis to starting treatment decreased from 2005 to 2007 (APC=-10.22%, P<0.001), and then showed an upward trend from 2007 to 2022 (APC=1.29%, P<0.001). The proportion of elderly patients with baseline CD4+ level≤200 showed a turning point in 2013 ［95% CI: 2008-2018］, and it decreased from 2005 to 2013 (APC=-8.11%, P<0.001).

From 2005 to 2022, the elderly patients who first received ART in Guizhou province were mainly male, married, heterosexual transmission, 1-2 years from diagnosis to treatment, and baseline CD4+ level ≤200, and the proportion of elderly patients was on the rise. Follow-up management strategies of ART should be developed for the elderly population to improve the quality of ART.

To analyze the impact of pain intensity on depression levels among rural elderly individuals, and to explore the mediating role of Activities of Daily Living (ADL) and the moderating effect of internet use.

This study was based on the 2020 China Health and Retirement Longitudinal Study (CHARLS). Partial correlation analysis was used to explore the relationships between pain intensity, ADL, depression levels, and internet use among rural elderly individuals. The Bootstrap method (Model 4,58) was used to analyze the mechanisms through which ADL and internet use affect the relationship between pain intensity and depression levels.

Pain intensity had a significant direct effect on depression levels among rural elderly individuals (β=1.537, 95% CI: 1.347-1.728). ADL played a significant mediating role between pain intensity and depression levels (β=0.319, 95% CI: 0.262-0.380). Internet use weakened the negative effect of pain intensity on ADL (β=0.508, P<0.01) and strengthened the negative effect of ADL on depression levels (β=-0.224, P<0.01).

Pain intensity positively influences depression levels among rural elderly individuals. ADL partially mediates the relationship between pain intensity and depression levels. Internet use moderates the effects between pain intensity and ADL, as well as between ADL and depression levels. Therefore, it is recommended to guide rural elderly individuals at the personal, family, and community levels to utilize internet technologies to disrupt the "pain-ADL decline-depression" chain reaction.

To identify potential drug targets related to preeclampsia and explore their public health value in precision prevention based on gene expression–associated genetic variants and Mendelian randomization.

By integrating genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data, potential druggable genes for preeclampsia were identified using Summary data-based Mendelian Randomization (SMR), Transcriptome-Wide Association Study (TWAS), and colocalization analysis. Drug annotation and potential side effect assessments were conducted using public drug databases, and Phenome-wide Mendelian Randomisation (MR-PheWAS) was applied to evaluate potential causal associations between the identified genes and 783 disease traits.

Seven potential drug targets were identified: ALDH2, BCAR1, IL27, MUTYH, PABPC1, SULT1A1 and SULT1A2. Among them, IL27 and SULT1A1 showed consistent and significant associations across multiple analyses. ALDH2 and MUTYH were identified as strong candidates with known involvement in oxidative stress and DNA repair pathways. Several genes were linked to existing drugs, suggesting potential for drug repurposing in preeclampsia.

Drug-target Mendelian randomization provides novel insights into the molecular mechanisms of preeclampsia and facilitates the identification of therapeutic targets. The findings offer a promising foundation for early screening, genetic risk stratification, and individualized prevention, contributing to the development of precision public health strategies for pregnancy-related disorders.

To evaluate the effect of exercise intervention on executive function in adult patients with depression.

Seven databases, Web of Science, PubMed, Embase, Cochrane Central, China Knowledge (CNKI), Wanfang Database, and Wipro Journal Network (VIP), were searched to include randomized controlled trials from the time of database construction to July 2024. Stata 18.0 and Review Manager 5.4.1 software were used for statistical analysis.

A total of 7 papers with 497 subjects were included. Meta-analysis showed that exercise intervention significantly enhanced executive function (SMD=0.29, 95% CI［0.13, 0.44］), with inhibitory control (SMD=0.31, 95% CI［0.02, 0.60］), working memory (SMD=0.25, 95% CI［0.09, 0.40］) and cognitive flexibility (SMD=-0.33, 95% CI［-0.49, -0.17］) significantly improved (P<0.05). Subgroup analyses showed that the exercise intervention of low to moderate intensity, 30-60 minutes per session, lasting 12-16 weeks had the best effect on improvement of inhibitory control; the exercise intervention of high intensity, 30-60 minutes per session, lasting 3-8 weeks had the best effect on improvement of working memory and cognitive flexibility.

Exercise intervention can effectively enhance the executive function and its subdomains in patients with depression, and it is recommended to choose the appropriate exercise modality and dosage according to the actual situation of the patients in order to optimize the effect of the intervention.

To analyze the burden of spinal injuries and its changing trends in China from 1990 to 2021, providing a theoretical basis for the prevention of spinal injuries.

Using the GBD 2021 database, indicators such as incidence, prevalence, and Years Lived with Disability (YLD) were extracted to describe the changes in the burden of spinal injuries in China. Data visualization was performed using the R language, the Joinpoint model was used to analyze the temporal trends of disease burden, the APC model was used to estimate age, period, and cohort effects, and the BAPC model was used to predict the standardized incidence rate of spinal injuries from 2022 to 2040.

Compared to 1990, the YLD rate and standardized YLD rate of spinal injuries in China showed a decline in 2021, while other indicators increased; the disease burden increased with age, with males having a higher burden than females; falls were the main cause of the disease burden; the average annual percentage change in standardized incidence rate, standardized prevalence rate, and standardized YLD rate from 1990 to 2021 was 0.007%, 0.156%, and -0.344%, respectively; the age-period-cohort model showed that the incidence rate increased with age, fluctuated upwards with time, and fluctuated downwards with the birth cohort; the prediction model indicated that the standardized incidence rate of spinal injuries will show a declining trend from 2022 to 2040.

The burden of spinal injuries in China from 1990 to 2021 showed an upward trend, with gender and age differences, falls being the main cause, and the elderly and males being the key burden groups; effective measures should be taken for intervention.