PDF
Full
Outline
To investigate the causal association of twelve lifestyle behaviors in six categories (including smoking, drinking, physical activity, sexual behaviors, sleep habits and nutrients) on uterine fibroids using mendelian randomization (MR) method, and to investigate the mediating role of obesity related indicators.
Using genome-wide association study data, bidirectional MR analysis was first performed to identify exposures with causal associations with the outcome, which were then incorporated into multivariable MR to evaluate the independent causal effect of each variable, and finally two-step MR was used to evaluate the mediating role of obesity in the above causal pathways. Univariable MR analysis primarily employed the inverse-variance weighted (IVW) method, with the MR-Egger regression and the weighted median method used as the robustness verification methods; Multivariable MR was performed using the multivariable IVW method.
IVW results showed that genetically predicted regular smoking (OR=1.150, 95% CI: 1.006-1.316, P=0.041), higher alcohol intake (OR=1.306, 95% CI: 1.092-1.563, P=0.004) and higher carbohydrate intake (OR=1.681, 95% CI: 1.151-2.456, P=0.007) were risk factors for uterine fibroids, and were consistent with the results of the MR-Egger regression and the weighted median method. No reverse causal relationship was found in reverse MR analysis (all P values<0.05). Multivariable MR analysis showed that regular smoking (OR=1.302, 95% CI: 1.124-1.507, P<0.001) and carbohydrate intake (OR=1.410, 95% CI: 1.053-1.887, P=0.022) had independent causal effects on uterine fibroids. The two-step MR analysis showed that the waist hip ratio adjusted by body mass index mediated the effect of regular smoking on uterine fibroids, with a mediation proportion of 16.2%.
Regular smoking and higher carbohydrate intake are associated with an increased risk of uterine fibroids, with obesity partially mediating the relationship between regular smoking and uterine fibroids, emphasizing the importance of healthy lifestyle and weight management in the prevention of uterine fibroids.
PDF
40
18
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
