To assess the body mass index (BMI), percentage of body fat (PBF), and bone age of school-age children in Xuzhou city, and to explore the relationship between BMI, PBF, and bone age, so as to provide reference for promoting the health of children.

A cluster sampling method was used to select 601 students of grade three from three schools in Xuzhou from July to August 2023, questionnaire surveys and physical examinations were used to collect children’s data, and disordered multi-classification logistic regression analysis was used to explore the association between different types of BMI or PBF and bone age development.

The rates for thinness, overweight, and obesity in boys were 14.2%, 11.1%, and 19.2% respectively, in girls were 17.6%, 9.3%, and 14.0%, respectively; Multivariate logistic regression showed that after adjusting for covariates such as gender, development of secondary sexual characteristics, average monthly household income, birth weight, father’s height, and mother’s height, the risk of early bone age development was significantly increased in both the BMI obese and overweight groups compared to the BMI normal group (OR=10.10, 95%CI:4.83-21.12; OR=3.78, 95%CI:1.53-9.33); The PBF high body fat group had a significantly increased risk of early bone age development compared to the PBF normal group (OR=3.79, 95%CI:2.01-7.13); BMI obese and PBF high body fat groups are protective factors for delayed bone age development (OR=0.40, 95%CI: 0.20-0.78; OR=0.52, 95%CI:0.31-0.87).

Overweight and obese children are prone to premature bone age. It is recommended to regularly monitor weight, bone age and body composition while preventing and controlling overweight and obesity in children.

To establish an evaluation index system of medical service capacity in county hospitals, so as to provide a reference basis for further evaluating the overall medical service strength of county-level hospitals.

Experts were invited to evaluate the relative importance of indicators at all levels of medical service capacity, and the weights of the dimensions of the indicators system were determined using analytic hierarchy process.

A total of 35 experts were invited to consult letter inquiries, and the recovery rate of the questionnaire was 94.43%. The CR of first-level indicators judgment matrix was 0.0223, and the CR of the second-level index judgment matrix under the three dimensions of structure, process and outcome were 0.0000,0.0741and 0.0052, all less than 0.1. Finally, the evaluation index system included 3 first-level indicators, 10 second-level indicators and 23 third-level indicators. The highest weight of the first-level indicators was the result(0.4570). Among the combined weights there were 11 indicators that exceeded the average weight of 0.0435 (1/23).

The evaluation index system of county hospitals based on analytic hierarchy process is objective and reliable, which can provide reference for health administrative departments at all levels and county hospitals to carry out medical service ability evaluation and ability improvement according to the actual situation.

To observe the level and effect of medical insurance for five sites of cancer in China using an area of Anhui Province as an example.

Using the district’s Medicare billing list data for the three-year period 2019-2021. Based on the concepts of actual compensation ratio, bottom-line compensation ratio and catastrophic health expenditure, the level and effect of medical security were calculated by level, cost and level of medical institution, etc.

Overall, the out-of-pocket share of the patients was maintained at around 30%, the out-of-pocket share of patients with high medical expenses was small (16.59%). The level of tertiary medical institutions’ actual compensation ratio was low (65.81%-70.52%), but overallit still exceeded the bottom-line compensation ratio under the 40% and 25% catastrophic health expenditure standards.

The multi-level health insurance system has begun to bear fruit. There is a need to equalize the protection for different types of illnesses, to strengthen the hierarchical diagnosis and treatment, and to pay further attention to the needs of patients with “serious illnesses and light treatment”.

To explore the influence of social networks on health-related behaviors in stroke patients.

From July to September 2023, participants living in Guangdong were selected as the survey respondents using convenient sampling method. The general information questionnaire, stroke health-related behavior questionnaire and social network questionnaire were used to collect data. Social network analysis was used to explore network characteristics and draw social network diagrams. Latent class analysis was used to explore health-related behavior patterns of stroke. Kruskal-Wallis H test and Bonferroni test were used to compare the differences in social networks of different health-related behavior patterns.

Stroke health-related behaviors can be divided into three categories, namely "good health behavior group" (C1, 58.15%), "smoking and drinking group" (C2, 24.60%), and "sedentary lifestyle and imbalanced diet and sleep group" (C3, 17.25%). The network effective size, efficiency, and betweenness centrality of the "smoking and drinking group" and the "sedentary lifestyle and imbalanced diet and sleep group” were lower than that of the "good health behavior group" (P<0.05/3). In contrast, the density, network hierarchy, network constraint, percentage of individuals who smoked and drank, and percentage of individuals who did not exercise and ate healthily of the two groups were higher than that of the "good health behavior group" (P<0.05/3).

Social network characteristics with high betweenness centrality, low hierarchy, low constraint and high network efficiency can promote health-related behaviors of stroke. Building a social network with equality, low constraint and positive healthy interaction is helpful for community stroke prevention and treatment.

To analyze the impact of nighttime sleep duration on depressive symptoms in the lifestyle habits of elderly people with multiple comorbidities in China.

Using the fifth round of the China Health and Retirement Longitudinal Study project, the depression mood of elderly people with multiple comorbidities was evaluated based on the Center for Disease Control Depression Rating Scale (CSE-D-10). Nighttime sleep was divided into five levels:<6 h, 6 to <7 h, 7 to <8 h, 8 to <9 h, and ≥9 h. Multivariate logistic regression analysis was conducted to investigate the influencing factors of depression in elderly people with multiple comorbidities. Random forest model was used to analyze the importance of nighttime sleep in the risk of depression in elderly people with multiple comorbidities. Restrictive cubic spline curves were used to further explore the dose-response relationship between nighttime sleep duration and the risk of depression.

A total of 1 249 elderly individuals with multiple comorbidities were included, aged (68.51±5.91) years. Multivariate logistic regression analysis showed that the risk of depression in elderly individuals with multiple comorbidities who slept at night for 6 to <7 hours (OR=0.447 (95%CI: 0.309-0.646)), 7 to <8 hours (OR=0.550 (95%CI: 0.351-0.862)), and 8 to <9 hours (OR=0.498 (95%CI: 0.323-0.768)) was relatively lower compared to those who slept for less than 6 hours. Discomfort caused by pain, ADL, life satisfaction, and stroke are the influencing factors for depression in elderly people with multiple comorbidities (P<0.05). The results of the random forest model show that the importance score of nighttime sleep on depression symptoms is relatively high. The results of the restricted cubic spline curve indicate a non-linear relationship between nighttime sleep and the risk of depression symptoms. The risk of depression symptoms decreases with 6-8 hours of nighttime sleep, and increases with less than 6 hours or more than 8 hours of nighttime sleep.

Nighttime sleep has an impact on the occurrence of depression in elderly people with multiple comorbidities. It is recommended that elderly people maintain 6-8 hours of nighttime sleep to effectively reduce the risk of depression and have certain significance for early prevention and control of depression in the elderly population.

To explore the relationship between social media addiction and anxiety among college students and the role of bedtime procrastination and stress perception.

A total of 15493 college students were selected by convenience sampling in September 2023 with using the Bergen Social Networking Addiction Scale, the Bedtime Procrastination Scale, the Chinese Perceived Stress Scales and the Generalized Anxiety Disorder 7-item Scale. SPSS25.0 macro program PROCESS was used to analyze the mediating effect of bedtime procrastination and the moderating effect of stress perception.

The social media addiction was positively predicted college students’ anxiety (β=0.307, P<0.001). Bedtime procrastination partially mediated the relationship between social media addiction and anxiety in the college students. The mediation effect value was 0.060 (95% Bootstrap CI=[0.055-0.065]), the mediating effect accounted for 19.54% of the total. Stress perception moderated the relationship between bedtime procrastination and anxiety (β=0.094, P<0.001). As the level of perceived stress increased, the positive association between bedtime procrastination and anxiety became stronger.

Social media addiction can directly affect anxiety in the college students, or indirectly affect it through bedtime procrastination, and perceived stress moderates the path from bedtime procrastination to anxiety in the mediation model.

To evaluate the information quality of hypertension-related videos on the TikTok short video platform and assess their potential value for public health education.

In June 2024, we searched the TikTok short video platform using the keyword "hypertension" selecting the top 200 videos and ultimately including 177 videos for quality evaluation. Structured content integrity assessment tools and the DISCERN video quality assessment tool were used to evaluate the videos. The correlation between video quality and characteristics (duration, likes, comments, favorites, and shares) was studied.

The 177 videos received 11 250 432 likes, 366 588 comments, 3 265 929 favorites, and 3 780 513 shares. The median video length was 111 seconds (74, 158), and the median upload days were 672 days (147, 878). 89.3% of the videos were posted by doctors, 8.5% by individual science communicators, and 2.3% by news agencies. 98.9% of the videos had subtitles, all featured individuals, and only 26.0% included animated demonstrations. Content integrity scores were: definition 0.19±0.40, symptoms 0.11±0.32, risk factors 0.29±0.50, assessment 0.36±0.45, management 0.81±0.47, and outcomes 0.63±0.58. 90.4% of the videos had a DISCERN score of ≤50, indicating "average" or below quality, with no significant difference in DISCERN scores among different publishers (P>0.05). DISCERN scores were significantly correlated with video duration (r=0.409, P<0.001).

The overall quality of hypertension-related videos on TikTok is low, with a significant positive correlation between video duration and quality. High-quality videos receive less attention, making TikTok an unsuitable platform for hypertension education due to low information quality and reliability.

To analyze the participation of mutual help and pension and influencing factors of the elderly in China, and to provide a reference basis for the long -term development of mutual help.

Based on the China Longitudinal Aging Social Survey (CLASS) data, single -factor deck analysis, non-conditional logistic regression and Shapley decomposition method was used to analyze the influencing factors and differences in the participation of the elderly people in my country.

The participation rate of mutual support for the elderly in China was only 19.72%, the participation level was low, and the awareness of mutual support for the elderly was weak. Multivariate Logistic regression results showed that the participation of the elderly in mutual support for themwas affected by the demographic characteristics, personal physical conditions, family conditions, pension concepts and ways. Shapley decomposition showed that the contribution rate of each factor to the elderly’s participation in mutual support for the elderly was different, and the physical condition of the elderly had the greatest impact on their participation in mutual support for the elderly, the contribution rate was 19.96%. The second was the participation in insurance and the need for help from others, with the contribution rates of 19.27% and 12.33% respectively.

It’s of great importance tocreate a platform for mutual assistance for the elderly, improve the government incentive mechanism, improve the community support network, and create a good atmosphere of mutual assistance, strengthen mutual assistance pension and education, and play a role of family support.

To investigate the role of ferroptosis in striatum damage induced by combined exposure of microplastics and manganese by establishing a mouse model following microplastics and manganese alone or combined exposure.

Forty SPF male C57 mice were randomly divided into control group, manganese exposure group, microplastics exposure group and combined exposure group. Neurobehavioral tests including rotarod test, open field test and sucrose preference test were performed. The contents of divalent iron, malondialdehyde and glutathione in striatum of mice were detected by using the kit. Western blotting was used to detect the protein expressions of SLC7A11, GPX4 and FPN1 in striatum of mice. Real-time PCR was performed to detect the expression of miR-124. Single factor analysis of variance was used for comparison of multiple groups of data, and LSD test was used for further pairwise comparison.

Behavioral tests showed that the residence time of the rotating rod (all P<0.001), the residence time in the central zone of open field test (all P<0.001), total distance of open field test (all P<0.001) and the sucrose preference rate (P_manganese=0.010; P_{microplastics}<0.001) in manganese exposure group and microplastics exposure group decreased significantly compared with that of the control group. Compared with the manganese exposure group and microplastics exposure group, the residence time of the rotating rod, the residence time in the central zone of the open field test and the total distance of the open field test of combined exposure group decreased significantly (all P<0.001). In addition, the sucrose preference rate of the combined exposure group was lower than that of the manganese exposure group (P=0.001). At the same time, compared with the control group, the contents of Fe²⁺ in striatum of mice in manganese exposure group and microplastics exposure group increased (P_manganese=0.002; Pmicroplastics=0.001), the contents of GSH decreased (P_manganese=0.015; Pmicroplastics<0.001). The content of MDA in the striatum of mice in microplastics exposure group increased (P<0.001). Furthermore, the contents of Fe²⁺ and MDA in striatum of mice in combined exposure group were higher than those in manganese exposure group (P_Fe²⁺=0.004; P_MDA<0.001) and microplastics exposure group (P_Fe²⁺=0.008; P_MDA=0.007), while the content of GSH was lower than that in the manganese exposure group (P<0.001). The protein expressions of SLC7A11 in manganese exposure group (P=0.010) and microplastics exposure group (P=0.001) were lower than that in the control group. The protein expression of GPX4 in microplastics exposure group was lower than that in the control group (P=0.007), and the protein expression of GPX4 in the combined exposure group was lower than that in the manganese exposure group (P=0.006). The protein expressions of FPN1 in the manganese exposure group (P=0.005) and microplastics exposure group (P=0.002) were lower than that in the control group and the protein expression of FPN1 in the combined exposure group was significantly lower than those in the manganese exposure group (P=0.008) and microplastics exposure group (P=0.005). Compared with the control group, the expressions of miR-124 in striatum of mice in manganese exposure group (P=0.002) and microplastics exposure group (P<0.001) increased. At the same time, the expression of miR-124 in the striatum of mice in the combined exposure group was higher than those in the manganese exposure group and microplastics exposure group (all P<0.001).

Combined exposure of microplastics and manganese might lead to striatum damage in mice through the regulation of ferroptosis, and then cause motor dysfunction and anxiety-depression-like behavior.

To study the effects of superfine grinding treatment on the composition and efficacy of loquat branches.

After the loquat branches were superfine grinding treated, the contents of total phenols, total flavonoids, polysaccharides, ursolic acid, oleanolic acid in the extracts from loquat branches with different particle sizes were detected by spectrophotometry and high-performance liquid chromatography. The in vitro antioxidant capacity of extracts from superfine loquat branches was evaluated by DPPH, ABTS free radical scavenging assay and FRAP assay. SPF-grade male Kunming mice were randomly divided into blank/model control group, drug group, loquat leaf control group, and low, medium, and high dosage of superfine loquat branches according to their body weights. The expectorant effect of extracts from superfine loquat branches was evaluated by phenol red excretion assay, and the antitussive effect of extracts from superfine loquat branches was evaluated by ammonia-induced cough assay.

The total phenol, total flavonoid and oleanolic acid contents of the three particle size loquat branch groups were higher than those of the branch control group (P<0.05, P<0.01), the total phenol and total flavonoid contents of the 220-mesh and 400-mesh loquat branch groups were higher than those of the leaf control group (P<0.05), and the ursolic acid contents of the 220-mesh and 400-mesh loquat branch groups were higher than those of the branch control group (P<0.01). In the in vitro experiment, the DPPH IC₅₀ and ABTS IC₅₀ of the three particle size loquat branch groups were lower than that of the branch control group (P<0.05), and the FRAP value was higher than that of the branch control group (P<0.05), and the DPPH IC50 and ABTS IC50 of the 200 mesh and 400 mesh loquat branch groups were lower than that of the leaf control group (P<0.05), and the FRAP value was higher than that of the leaf control group (P <0.05). In the phenol red excretion experiment, the phenol red excretion was significantly elevated in mice in the high-dose superfine loquat branch group (P<0.05). In the ammonia-induced cough experiment, both medium-dose and high-dose superfine loquat branches groups prolonged the latency period of coughing and the number of coughs in mice (P<0.05).

Appropriate superfine grinding treatment can increase the content of the efficacy components of loquat branches, enhance their antioxidant effect, and at the same time, they have certain expectorant and antitussive effects.