To explore the time-varying association between adverse childhood experiences and social isolation in middle-aged and older adults and provide a scientific evidence for the early identification of people at risk of social isolation and the development of appropriate interventions.

Data were used from respondents who participated in the life history survey of the China Health and Retirement Longitudinal Study (CHARLS) and at least one of the surveysconducted between 2011 and 2020. Adverse childhood experienceswere collected through self-reporting and divided into four groups based on the number of adverse childhood experiences, which were categorized into the group that had not experienced adverse childhood experiences, the group that had experienced one type of adverse childhood experience, the group that had experienced two types of adverse childhood experiences, and the group that had experienced three or more types of adverse childhood experiences. A time-varying effect model was used to explore the age-varying association between adverse childhood experiences and social isolation among middle-aged and older adults, using age as the time variable.

A total of 14 397 middle-aged and older adults were included in the study. Compared with those who had not experienced adverse childhood experiences, those who had experienced one adverse childhood experience had a higher risk of social isolation between the ages of 61 and 70(OR=1.22, 95% CI:1.06-1.41); those who had experienced two adverse childhood experiences had a higher risk of social isolation between the ages of 50 and 65(OR=1.33, 95% CI: 1.13-1.57); and those who had experienced three or more adverse childhood experiences had a higher risk of social isolation between the ages of 45 and 58(OR=1.86, 95% CI:1.16-2.99).

There is aage-varyingassociation between adverse childhood experiences and social isolation among middle-aged and elderly people, with the more childhood adversities experienced, the younger the age at which social isolation occurs.

To analyze the relationship between social support networks and the sense of gain among elderly individuals in the community and further explore the mediating role of psychological resilience in this process.

Using cluster random sampling, elderly individuals aged 65 and above from three towns (districts) in Dongguan City, Guangdong Province—Tangxia, Songshan Lake, and Liaobu—were selected as the study population from May to July 2023. A total of 1 245 valid responses were included in the analysis. Stepwise linear regression and mediation effect models were used to investigate the relationships between social support networks, sense of gain, and psychological resilience.

A positive correlation was found between the sense of gain and psychological resilience (r=0.516, P<0.01), as well as between the sense of gain and social support networks (r=0.383, P<0.01). Additionally, a positive correlation was observed between psychological resilience and social support networks (r=0.321, P<0.01). Psychological resilience partially mediated the effect of social support networks on the sense of gain, with a mediation effect value of 1.113, accounting for 34% of the total effect.

There is a significant association between social support networks, psychological resilience, and the sense of gain among elderly individuals in the community. Social support networks enhance the sense of gain by improving psychological resilience.

To examine the association between physical activity and its different domains with sleep quality among rural older adults in Chengdu, and to further investigate whether this relationship differs between different age groups.

Using data from a cluster randomized controlled trial conducted from May 2021 to May 2023 in rural areas of Chengdu, the study included 511 older adults aged 60 years and above from eight villages. A questionnaire survey was conducted using the Physical Activity Scale for the Elderly (PASE), the Pittsburgh Sleep Quality Index (PSQI), and other instruments. Linear mixed models were used to analyze the relationship between physical activity andits three domains (leisure time physical activity, work-related physical activity, and household physical activity) and sleep quality.

There was a statistically significant association between leisure time physical activity and sleep quality (P< 0.05), and there was no statistically significant association of total physical activity, work-related physical activity, household physical activity with sleep quality (P > 0.05). The association between leisure time physical activity and sleep quality was more pronounced among those aged ≥ 70 years (β=-0.009, P=0.049).

Rural older adults with higher leisure time physical activity level have better sleep quality. There is a need to carry out intervention programs to increase leisure time physical activity level among rural older adults to improve their sleep quality.

To explore the relationship between the prevalence of arthritis and cognitive function in the elderly and to verify the mediating effect of activities of daily living(ADL) and the moderating effect of social engagement to provide a reference point for promoting active aging.

This study based on the data of China Health and Retirement Longitudinal Study (CHARLS) in 2020, a moderated mediated-effects model was constructed using the PROCESS 4.1 program to analyze the mechanisms of ADL and social engagement in the effects of arthritis on cognitive function in the elderly.

A total of 5 882 elderly were enrolled in this study. The prevalence of arthritis in the elderly had a significant negative effect on cognitive function (β=-1.050, P<0.001); ADL partially mediated between the two, with a significant mediating effect (95% CI:-0.430--0.194), and an effect value of -0.306, with an effect percentage of 29.1%; social engagement significantly moderated the effect of ADL on cognitive function (β=1.594, P<0.001), and the predictive effect of ADL on cognitive function was more significant for the elderly with low social engagement.

ADL mediates the relationship between arthritis prevalence and cognitive function in the elderly; social engagement moderates the relationship between ADL and cognitive function; the elderly should be more aware of precautions to reduce the incidence of the disease; family doctor service teams should strengthen the health management and early intervention of arthritis in the elderly and provide scientific guidance on the use of medication; enhance the ADL of the elderly; and encourage the social engagement of the elderly to strengthen their cognitive function and achieve active ageing.

To explore the influence of socioeconomic status on cognitive level and the longitudinal mediating role of loneliness and social participation among the elderly.

A total of 2 060 research samples were included in the 2011, 2014 and 2018 longitudinal data of the China Elderly Health Influencing Factors Longitudinal Survey (CLHLS), and the data were analyzed using cross-lagged mediation model.

There was a positive correlation between the pre-test socioeconomic status and the post-test cognitive level of the elderly, and the association was statistically significant （β=1.048, P<0.001）. The results of 95% of the bootstrap mediating effect test showed that the longitudinal mediating effect of loneliness in the elderly between socioeconomic status and cognition was insignificant -0.004 （-0.012-0.004）. The socioeconomic status of the elderly indirectly positively affected the cognitive level by positively affecting social participation 0.022 （0.009-0.036）, and the mediating effect was 33.06%. The longitudinal chain mediating effect between loneliness and social participation between socioeconomic status and cognition was significantly 0.010（0.002-0.019）, and the mediating effect was 21.03%.

The socioeconomic status of the elderly affects the cognitive level, the social participation of the elderly is the mediating variable of the socioeconomic status affecting the cognitive level,and there is a chain mediating effect between economic status and cognitive level in the elderly's loneliness and social participation. In the future prevention of cognitive dysfunction in older adults, special attention should be paid to the impact of socioeconomic status loneliness, and social participation.

To explore the complex relationship between pain, ability to perform daily activities, life satisfaction and sleep in older patients with chronic diseases, and to provide new perspectives and intervention strategies to improve their sleep.

Based on the data of China Health and Retirement Longitudinal Study (CHARLS) 2020, this study selected patients with chronic diseases aged 60 years and above as the study subjects, and screened out the sample size of 8 591 that met the criteria.T-test, analysis of variance (ANOVA), and Pearson's correlation analysis were used for the univariate analyses, and PROCESS 4.2 was used for the mediation effect analyses and tests.

Pain in older adults was negatively correlated with sleep duration (r=-0.197) and life satisfaction (r= -0.132), and positively correlated with ability to perform daily activities (r=0.292). The mediation test reported that pain in older adults had a direct effect on sleep duration (95% CI: -0.082--0.057), with ability to perform daily activities (95% CI: -0.015--0.017) and life satisfaction (95% CI: -0.005-0.002) acting as chained mediators between the two.

When improving the health management of older patients with chronic diseases, there is a need to focus on pain, daily mobility and life satisfaction in order to develop more effective intervention strategies.

To analyze the correlation between health literacy and health-related quality of life among the elderly in China.

A multi-stage random sampling method was used to measure the health literacy and health-related quality of life of the participants using short-form health literacy survey questionnaire (HLS-SF12) and the European five-dimensional five-level health scale (EQ-5D-5L), respectively. Health-related quality of life was evaluated by using the health utility value. Spearman’s correlation analysis, tobit regression analysis, and restricted cubic spline were used to analyze the correlation between health literacy and HRQoL in elder adults, and sensitivity analyses were performed by excluding participants with hypertension, diabetes mellitus, dyslipidemia, and overweight and obesity.

A total of 1 147 cases of older adults aged ≥60 years were included, with 581 male cases (50.65%) and the age range of 71-75 years was the most prevalent, with 361 cases (31.47%). The mean level of health literacy was 34 (30, 36) points, and the mean level of health utility value was 0.94 (0.83, 1.00). Spearman correlation analysis found a positive correlation between health literacy and health utility value (r_s=0.370, P<0.001). Tobit regression analysis found a positive correlation between health literacy and health utility value (β=0.007, 95% CI: 0.005-0.008, P<0.001). Restricted cubic spline showed an irregular “right skewed” distribution between health literacy and health utility value after adjusting for confounding factors; The relationship between health literacy and health utility value still existed in the sensitivity analyses of elder adults who excluded participants with hypertension, diabetes, dyslipidemia, and overweight and obesity.

The health literacy level is an influential factor in the health-related quality of life of the elderly, and improving the health literacy of the elderly is conducive to the patients’ beneficial behaviors such as disease prevention and control, health care, and health promotion.

To provide a theoretical basis for improving the monitoring and management of hepatitis B case data in Qinghai by analyzing the duplicate reporting (re-reporting) of hepatitis B cases in Qinghai from 2018 to 2022.

The data of cases with reported disease type of hepatitis B in Qinghai Province from 2018 to 2022 were collected through the National Notifiable Disease Reporting System (NNDRS), and five types of double-checking rules were set to check hepatitis B cases by using R4.3.2 software , and the restated caseswere further analysedusing χ² test and Cochran-Armitage trend test.

The cumulative number of repeated reported hepatitis B cases in Qinghai Province from 2018 to 2022 was 6 107 (13.01%), and when the time span of the hepatitis B cases included in the study ranged from 1 to 5 years, the restatement rates were 3.76%, 6.90%, 9.31%, 11.39%, and 13.01%, respectively, and the restatement rate was higher the longer the time span of the included cases (Z=57.931,P<0.001). When the time span of the included cases was 5 years, the restatement rates of the eight cities and states in Qinghai Province ranged from 9.45% to 15.25%, and the restatement rates of acute, chronic, and unclassified hepatitis B cases were 11.79%, 13.06% and 12.58%, respectively.

There is a more serious inter-regional and inter-annual restatement of hepatitis B cases reported in Qinghai Province from 2018-2022, and hepatitis B checking should be strengthened at all levels and in all departments, and targeted measures should be taken to reduce the situation of repeated reporting and improve the monitoring and management of hepatitis B cases.

To investigate the current status and related factors of distribution of HIV delivery test among men who have sex with men (MSM) in Guangxi, aiming to provide references for promoting expanded HIV testing strategies for MSM.

From September 2021 to February 2022, 330 MSM were recruited in Nanning, Guilin, Liuzhou and Beihai, Guangxifor aprospective cohort study.Generalized Estimating Equations were used in analyses of related factors.

Among the 319 MSM participants in the follow-up survey, 63.95% (204/319) underwent HIV delivery test.Multivariate generalized estimating equations showed that MSM with health insurance (aOR=1.959, 95% CI: 1.047-3.664), those with a college and above (aOR=1.736, 95% CI: 1.173-2.569), those who had undergone HIV testing in the past 3 months (aOR=3.565, 95% CI: 2.048-6.205), and those who had used HIV self-testing in the past 3 months (aOR=1.780, 95% CI: 1.227-2.582) were more willing to undergo HIV delivery test.

The proportion of HIV delivery test of MSM in Guangxi was63.95%.MSM with health insurance, a college or above education,had HIV test, and HIV self-testing in the past 3 months were more willing to undergo HIV delivery test.We should strengthen the publicity and promotion of HIV delivery test, encouraging individuals to participate in HIV delivery test in this population.