To analyze the relationship between stress resistance, symptom interference, and cancer-related fatigue in cancer patients undergoing radiotherapy and chemotherapy.

A total of 336 cancer patients undergoing radiotherapy and chemotherapy in the First Affiliated Hospital of Hebei North University from October 2020 to October 2021 were selected by convenient sampling. The related data were collected by general condition questionnaire, cancer fatigue scale (CFS), Chinese version memory symptom assessment scale (MSAS-Ch), and stress resistance scale (CD-RICS).

The scores of cancer-related fatigues, stress resistance, and symptom disturbance were 30.55 ±8.26, 62.14 ±14.04, and 1.11 ±0.38, respectively. The level of stress resistance played an intermediary role in symptom interference and cancer-related fatigue, accounting for 26.26% of the total effect. The level of stress resistance had a regulatory effect between symptom interference and cancer-related fatigue (β = 0.102, ΔR²=0.382, P < 0.05).

The level of stress resistance plays a mediating effect and regulation between symptom interference and cancer-related fatigue. Encouraging patients to strengthen the level of stress resistance, strengthen positive psychological construction, and weaken the level of symptom interference is helpful to reduce cancer-related fatigue.

To summarize the key elements and shortcomings of relevant policies in the field of mental health in China, so as to provide reference for the formulation and improvement of follow-up policies in the field of mental health in China.

Using NVivo11Plus software and content analysis method, a two-dimensional analysis framework of “policy tool-policy object” was constructed to quantitatively analyze 141 relevant policy texts in the field of mental health at the national level from 1999 to 2023 in China.

China has paid growing attention to mental health, and the National Health Commission, the Ministry of Education, and the Ministry of Civil Affairs were the core departments of policy formulation. The internal structure of supply-oriented policy tools was out of balance, and the application of environmental policy tools was insufficient. Demand-based policy tools were the least used, accounting for 49.96%, 28.36%, and 21.68%, respectively. The policy object was concentrated in the whole system, health system, and education system, accounting for 32.81%, 24.59%, and 21.94%, respectively.

It is suggested that the policy design balance the structure of policy tools, increase the supply of resources, apply strategies and measures, strengthen mental health education and promotion, strengthen community grass-roots mental health services, and standardize the development of social mental health service institutions so as to improve mental health and mental hygiene policy system.

Based on the US National Health and Nutrition Survey from 2005 to 2021, an interpretable machine learning method was used to identify patients with depression in people over 65 years old.

The data of 2005 Mel 2018 and 2019-2020 were used as training set and test set, respectively, and three machine learning models of Lasso Logistic, random forest, and XG Boost were fitted. The best model of area under the curve (AUC) on the test set was selected and explained by interpretable machine learning model SHAP.

The AUC value of XG Boost model was the highest, which was 0.933 (0.912-0.954). Sleep problems, health problems, and eosinophil count were the top three important variables affecting senile depression. The absolute values of SHAP were 1.16, 0.83, and 0.55, respectively, which showed the main influencing factors of each individual.

Machine learning is superior to logistic regression model in predicting depression in the elderly. Interpretable machine learning can explain the model from the global and individual levels to make predictions, open the black box of machine learning models, and can be used as a supplement to machine learning models in practical application.

To investigate the positive rate of HBsAg and HBsAb in the population born during 2004 and 2022 in Jiangxi Province.

By using stratified cluster sampling method, venous blood samples were collected from 8 126 people born after 2004 from 2016 to 2022 in 11 districts and cities of Jiangxi Province, and the sera were separated. HBsAg and HBsAb were detected by Elisa method, and the positive rate was calculated. The chi-square test was used to analyze the difference of positive rate among different groups.

The positive rates of HBsAg and HBsAb among people born during 2004 and 2022 in Jiangxi Province were 1.40% and 74.92%, respectively. The positive rates of HBsAg in males and females were 1.14% and 1.80%, respectively (χ²=6.18, P=0.013) and the positive rates of HBsAb were 75.55% and 74.00%, respectively (χ²=2.51, P=0.113). The positive rates of HBsAg were 1.17%, 1.31%, 2.14%, and 3.12% (χ²=13.49, P=0.004) at the age of 4, 9, 14, and 15 to 18 years, respectively, and the positive rates of HBsAb were 85.65%, 60.26%, 50.04%, and 46.42%, respectively (χ²=9.90, P <0.001). The positive rates of HBsAg and HBsAb in urban and rural areas were 1.62% and 1.14% (χ²=11.99, P=0.001), 74.18%and 75.81%, respectively (χ²=2.83, P=0.095). The positive rates of HBsAg and HBsAb in people born before and after 2012 were 2.18% and 1.14%, 52.18%, and 82.28%, respectively (χ²=7.64, P < 0.001). The positive rate of HBsAg in 11 districts and cities was between 0.45% and 2.79% (χ²=37.18, P < 0.001), and the positive rate of HBsAb was between 69.88% and 84.30% (χ²=65.61, P < 0.001).

The positive rate of HBsAg among the people born during 2004 and 2022 in Jiangxi Province is low, and the prevention and control of hepatitis B is effective. There are population and regional differences in the prevalence of HBsAg and HBsAb. Targeted measures should be taken to further improve the effect of prevention and control.

To investigate the prevalence and influencing factors of hyperhomocysteinemia among Tibetan residents in the west of Xizang Ali.

By using the method of multi-stage cluster random sampling, Tibetan residents were randomly selected from the western area of Xizang Ali for physical examination and questionnaire survey, and blood routine and biochemical indexes were collected. The prevalence and influencing factors of hyperhomocysteinemia in this area were analyzed by chi-square test and multivariate logistic regression.

A total of 1 362 Tibetan residents in the western region of Xizang Ali were investigated. The results showed that there were 1 044 patients with hyperhomocysteinemia, with a prevalence rate of 76.7%. The prevalence rate of males (84.8%) was higher than that of females (71.5%). Smoking (OR=1.988, 95%CI:1.076-3.675), poor household (OR=1.775, 95%CI: 1.204-2.540), hyperuricemia (OR=3.416, 95%CI: 2.494-4.679), hypercholesterolemia (OR=4.051, 95%CI: 2.811-5.838), and hypertriglyceridemia (OR=2.589, 95%CI: 1.765-3.798) were risk factors of hyperhomocysteinemia. Female (OR=0.538, 95%CI: 0.384-0.752) and agricultural and pastoral areas (OR=0.312, 95%CI:0.156-0.625) were protective factors.

The prevalence rate of hyperhomocysteinemia is high in the western region of Xizang Ali. Sex, residence, smoking, and poor households are the influencing factors of hyperhomocysteinemia. Hyperhomocysteinemia is significantly associated with hyperuricemia, hypercholesterolemia, hypertriglyceridemia, and other diseases.

To explore the causal relationship between the characteristics of glycemic traits (fasting blood glucose, fasting insulin, glycosylated hemoglobin, and insulin resistance) and benign colorectal neoplasm (colorectal adenomas, benign rectal neoplasm, and benign colon neoplasm).

The instrumental variables of blood glucose characteristics were extracted from MAGIC and GLGCL alliance, and the genome-wide data of colorectal benign tumors came from Finn-Gen alliance. In this study, random effect inverse-variance weighted method (IVW), MR-Egger regression, and weighted median method (WMM) were used to analyze the causal relationship between four glycemic traits and benign colorectal neoplasm.

The results of IVW model showed that there was no causal relationship between fasting blood glucose (OR=0.999, 95%CI: 0.997-1.001), fasting insulin (OR=1.002, 95%CI: 0.998-1.006), glycosylated hemoglobin (OR=1.001, 95%CI: 0.999-1.004), insulin resistance (OR=0.999, 95%CI: 0.997-1.002), and colorectal adenoma. There was no causal relationship between fasting blood glucose (OR=0.909, 95%CI: 0.684-1.209), fasting insulin (OR=1.220, 95%CI: 0.706-2.107), glycosylated hemoglobin (OR=0.678, 95%CI:0.440-1.046), insulin resistance (OR=1.161, 95%CI: 0.810-1.663) and rectal benign tumor. There was no causal relationship between fasting blood glucose (OR=0.966, 95%CI: 0.836-1.116), fasting insulin (OR=1.318, 95%CI: 0.906-1.916), glycosylated hemoglobin (OR=1.124, 95%CI: 0.882-1.431), insulin resistance (OR=1.071, 95%CI: 0.875-1.311) and benign tumors of colon.

There is no evidence of causal relationships of fasting blood glucose, fasting insulin, glycosylated hemoglobin, and insulin resistance with colorectal adenomas, benign rectal neoplasm, and benign colon neoplasm.

To investigate the effect of night shift work on metabolic syndrome (MS) in railway workers.

In total 7 635 railway workers who took part in the physical examination in the First Affiliated Hospital of Guangdong Pharmaceutical University from September to December 2021 were selected as the research subjects. Logistic regression was used for correlation analysis and restricted cubic spline (RCS) was used to analyze the dose-response relationship.

The prevalence rate of metabolic syndrome in railway workers was 15.1%. After adjusting the confounding factors, former night shift (OR=1.198, 95%CI: 1.002-1.431) and current night shift (OR=1.219, 95%CI: 1.048-1.417), night shift duration of 6.0 ~ < 11.0 years (OR=1.323, 95%CI: 1.092-1.603) and ≥ 11.0 years (OR=1.256, 95%CI: 1.029-1.534), night shift twice a week (OR=1.269, 95%CI: 1.074-1.498), 3 times (OR=1.217, 95%CI: 1.001-1.479), and ≥ 4 times (OR=1.295, 95%CI:1.032-1.623) were significantly associated with the prevalence of MS in railway workers. The results of RCS showed that there was a linear positive correlation between the working years of night shift and the risk of MS (P _total < 0.001, P _non-linear=0.0760). The risk of MS began to increase after 1 year of night shift and reached the highest after 14.1 years.

Night shift work will lead to an increase in the risk of MS among railway workers, and the higher the number of years of night shift work, the higher the risk.

To develop the influenza vaccine hesitation scale for the elderly aged 60 and above and evaluate its applicability.

Based on the Chinese version of the parents’ hesitation scale for children’s influenza vaccination, combined with the characteristics of the elderly population, the influenza vaccine hesitation scale for the elderly aged 60 and above was developed, and the reliability and validity of the scale were evaluated.

The scale finally included 3 dimensions and 14 items, the score of the total scale was 32.82 ±7.99, and the correlation coefficient between each item and the score of the total scale was between 0.20 and 0.87 (all P < 0.05). Exploratory factor analysis showed that the Kaiser-Meyer-Olkin （KMO） value of the scale was 0.916 (χ²_{approximation} = 14 315.26, P<0.05). Confirmatory factor analysis showed that the cumulative variance contribution rate of 14 common factors was 80.6%, GFI=0.909, IFI=0.961, TLI=0.952, and CFI=0.961,indicating that the overall fitness and structural validity of the model were good. Taking whether the elderly were vaccinated with influenza vaccine or not in the influenza season in 2022, the total vaccine hesitation score and the scores of “confidences”,“risk” and “support” were significantly correlated with the school standard (all P < 0.05). The Cronbach’s α coefficient of the scale was 0.859, indicating that the internal consistency reliability of the scale was high.

The influenza vaccine hesitation scale for the elderly developed in this study is good in reliability, validity and applicable stability, which can be used to evaluate the hesitation level of influenza vaccine in people aged 60 and above.

To analyze the current situation of cognitive function of the elderly in China and the influence of internet use on the cognitive function of the elderly.

In total 10 546 people aged 60 and above were included in the study. The t-test and variance analysis were used to analyze the differences of cognitive function among elderly groups with different characteristics. Multiple linear regression model was used to explore the effect of internet use on the cognitive function of the elderly.

A total of 2 987 elderly people used the internet, accounting for 28.32% of the total, and the average score of cognitive function of the elderly who used the internet was 14.75±1.86. The average score of cognitive function of the elderly who had not used the internet was 13.34±2.91. There was a significant difference between the two groups (t=-29.48, P < 0.001). The use of the internet was related to the cognitive function of the elderly (β = 0.12, 95%CI: 0.608-0.845, P < 0.001), and the cognitive function of the elderly who used the Internet was better.

Internet use has an impact on the cognitive function of the elderly, and it is suggested that targeted measures be taken to improve the cognitive function of the elderly.

To investigate the relationship between childhood bullying and loneliness of the floating elderly in mega-cities.

By using the method of quota sampling, an effective questionnaire survey was conducted among 1 000 migrant elderly people ≥ 60 years old in Qingyundian Town, Daxing District, Beijing in 2022. The information of social demography, loneliness, and childhood bullying were collected. Univariate analysis and ordinary least squares (OLS) regression model were used to analyze the relationship between childhood bullying and loneliness of the floating elderly in mega-cities.

After adjusting demographic variables, socio-economic status variables, physical health variables, length of stay in Beijing, and proficiency in Mandarin and social integration, the loneliness scores of floating elderly people in mega-cities who suffered childhood bullying increased by an average of 5.616 (4.153-7.079) points. Self-rated health, Mandarin proficiency, marital satisfaction, and social integration played a regulatory role in“childhood bullying-loneliness”. Compared with model 1, the 95%CI of models 2, 3, and 4 changed from 8.014 (6.580-9.447) to 7.498 (6.027-8.968), 7.402 (5.961-8.843), and 5.616 (4.153-7.079), respectively. Sub-sample regression showed that the results were stable in different gender, age, household registration, and marriage and spouse mobility (all P < 0.01), but there were differences in education level.

The floating elderly in mega-cities who suffered childhood bullying have a higher level of loneliness, and self-rated health, proficiency of Mandarin, marital satisfaction, and social integration are helpful to weaken the above-mentioned relationship.