To analyze the disease burden and trend of anxiety disorders in adolescents aged 10-24 in China from 1990 to 2021.

Based on the 2021 global burden of disease (GBD) database, the incidence, prevalence, and disability-adjusted life years (DALYs) rate of anxiety disorders in adolescents aged 10-24, along with their corresponding standardized rates, were extracted as indicators of disease burden. With 1990 as the baseline, the overall and gender- and age-specific changes in these indicators in 2021 were analyzed. Joinpoint regression analysis was used to dynamically analyze the changes in these three disease burden indicators from 1990 to 2021. The grey prediction model GM(1,1) was employed to estimate the disease burden trend of anxiety disorders in adolescents over the next decade.

In 2021, incident case number, prevalent case number, and DALYs of anxiety disorders in adolescents were 1 637 600, 10 267 500, and 12 793 000, respectively, which decreased by 30.51%, 33.91%, and 33.59%, as compared with 1990; however, the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents were 451.49/100 000, 3 481.74/100 000, and 418.95/100 000, respectively, which represented an increase of 2.29%, 2.03%, and 2.37%, as compared to 1990; there are differences in the disease burden for anxiety disorders between genders, which were manifested that girls are more likely to suffer from anxiety disorders than boys; and the standardized incidence of anxiety disorders among adolescents between the ages of 10-14 years was higher, while the standardized prevalence and the standardized DALYs rate among them between the ages of 15-19 years were higher. The Joinpoint regression model showed that the standardized incidence, standardized prevalence, and standardized DALYs rate of anxiety disorders in adolescents aged 10-24 increased from 1990 to 2021, with a larger increase from 2019 to 2021. The grey prediction model indicated that by 2031, the standardized incidence, standardized prevalence, and standardized DALYs rate would reach 559.44/100 000, 3 597.01/100 000, and 430.65/100 000, respectively.

The disease burden of anxiety disorders in adolescents aged 10-24 years is concerning, and interventions for anxiety disorders should be performedinadolescents of different genders and ages.

To explore the relationship between cardiovascular health (CVH) and depression in postmenopausal women.

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, logistic regression analysis was conducted to examine the association between CVH and depression in postmenopausal women. Restricted cubic spline (RCS) models were employed to reveal potential nonlinear associations between the two.

After adjusting the covariates, the risk of depression was significantly reduced in the moderate and high CVH groups (OR=0.50, 95% CI: 0.34-0.72; OR=0.25, 95% CI: 0.07-0.90). A significant nonlinear association was also observed between CVH and depression (P-overall<0.001, P-nonlinear<0.001). Subgroup analysis results showed a significant negative association between high levels of CVH and depression among 18 to 59 years of age (OR=0.12, 95% CI: 0.02-0.55), non-Hispanic blacks (OR=0, 95% CI: 0.00-0.00), other races (OR=0.14, 95% CI: 0.04-0.55), below high school (OR=0.06, 95% CI: 0.01-0.33), above high school (OR=0.12, 95% CI: 0.02-0.89), married/cohabiting (OR=0.06, 95% CI: 0.01-0.25), overweight/obese (OR=0.06, 95% CI: 0.02-0.21), and non-users of hormone replacement therapy (OR=0.12, 95% CI: 0.04-0.42).

A significant negative correlation exists between CVH levels and the risk of depression in postmenopausal women. This underscores the importance of CVH in the mental health of postmenopausal women. Healthcare providers should prioritize the potential psychological impact of CVH on postmenopausal women and incorporate it into comprehensive strategies for depression prevention and intervention.

To evaluate the impact of family doctor contract on the utilization of services in primary medical and health institutions.

Logit model and propensity score matching method were used for analysis.

The signing rate of family doctors was 75.8%, and the service utilization rate of primary medical and health institutions was 65.28%. The propensity scores matching results showed that after kernel matching and radius matching, ATT of family doctor contract on utilization of primary medical and health institutions was 0.052 4 and 0.068 3. The contracted services of family doctors had increased the utilization rate of primary medical and health institutions of residents with chronic diseases by 13.84%. The contract services of family doctors had no statistical significance on the utilization rate of primary medical and health institutions of non-chronic residents. The contracted services of family doctors had increased the average utilization rate of elderly residents to primary medical and health institutions by 9.25%. The contracted services of family doctors increased the average utilization rate of non-elderly residents to primary medical and health institutions by 5.98%.

The signing rate of family doctors and the utilization rate of primary medical and health institutions are both good. Contracted family doctors can promote the utilization of primary medical and health institutions by residents, and the contracted service of family doctors is more obvious to the utilization of primary medical and health institutions by people with chronic diseases and the elderly.

To assess the impact of the utilization of basic public health services on residents’ willingness to the first choice of medical institutions for treatment.

This study utilized information from a resident survey conducted by the Provincial Natural Science Foundation Project. The project adopted a multi-stage sampling method and utilized the resident household survey questionnaire, which was conducted from January 2020 to October 2021 in Shandong Province. A total of 2 917 valid questionnaires were obtained, and the survey respondents were residents aged 15 and above. Binary logistic regression model and propensity score matching (PSM) method were used for analysis.

The proportion of residents who have established health records was 63.9%, and the utilization rate of health education was 49.6%.83.8% respondents preferred to choose primary healthinstitutions for treatment. The results of propensity score matching showed that under the three methods of kernel matching, radius matching, and nearest neighbor matching, the average treatment effect on the treated (ATT) for the utilization of health education in residents’ willingness to the first choice of healthcare institutions were 0.084 3, 0.088 9, and 0.090 3, respectively.

The consultation rate of primary health institutions is performing well. Essential public Health services usage had a positive effect on residents’ willingness to choose primary health institutions for medical treatment. It is recommended to increase constructive investment in primary health institutions, enhance the service supply capacity of providers and strengthen the relevanceof basic public health services for demanders.

To investigate the association between smoking behavior and diabetes among adult hypertensive patients aged 20 years and above.

Using annual health examination data from the National Basic Public Health Service Program for hypertensive patients in Jianye District, Nanjing (2019-2023), logistic regression was employed to analyze the association between smoking behavior and diabetes in adult hypertensive patients aged≥20 years. Restricted cubic spline curves were used to explore the dose-response relationships between daily cigarette consumption, smoking duration, and smoking index with diabetes.

Among 55 128 participants, 14 102 were identified as having diabetes. Multivariable logistic regression analysis showed that, compared with non-smokers, former smokers (OR＝1.17, 95% CI: 1.01-1.35) and current smokers (OR＝1.18, 95% CI: 1.10-1.26) were positively associated with diabetes. Compared with non-smokers, hypertensive patients who smoked≥30 cigarettes/day, had a smoking duration of ≥50 years, or had a smoking index of ≥20 pack-years showed higher proportions of diabetes, with corresponding OR values (95% CI) of 1.66 (1.23-2.21), 1.13 (1.01-1.26), and 1.21 (1.12-1.31). A U-shaped dose-response relationship was observed between smoking duration and diabetes prevalence (non-linear P＝0.029). Subgroup analysis revealed that the association between smoking status and diabetes was more pronounced in younger age groups (interaction P<0.050).

Among hypertensive patients aged≥20 years, smoking behavior is positively associated with diabetes prevalence, and smoking duration shows a U-shaped association with diabetes.

To study the coordinated development of healthcare resource allocation and service utilization in Jiangsu Province.

Using various statistical methods, its spatio-temporal evolution characteristics and driving factors were profiled.

The degree of coupling coordination showed an overall upward trend during 2015-2021, which declined in 2020 but quickly rebounded in the following year; the province’s entropy-weighted TOPSIS composite index was basically below 0.5, with Nanjing, Wuxi, and Suzhou’s composite scores significantly higher than those of other cities, and the service utilization index as a whole was significantly higher than that of the resource allocation index; Lianyungang, in terms of the value of the degree of relative development, was much higher than that of the province’s other cities, presenting an extremely significant resource over-advancement type; the influence factors selected in this paper can be better realistic and statistically significant in terms of selection objectives and significance.

The coordinated development of medical resource allocation and service utilization of health institutions in prefecture-level cities in Jiangsu Province has obvious geographical boundaries of spatial and temporal changes,2015-2021. In addition, although the better economically developed areas performs better than the relatively less economically developed areas in terms of healthcare resource allocation and service utilization but shows a regression in the composite scores, healthcare resource allocation may be an entry point for the balanced development of the province. The study also find that factors such as population distribution and level of economic development have a significant impact on the degree of coordination over the seven years.

To measure and evaluate the compatibility between the level of outpatient chronic special disease coverage under the basic health insurance and the level of healthcare resource service utilization in Shanxi Province, so as to provide reference for the coordinated development of the level of outpatient chronic special disease coverage under the basic health insurance and the level of healthcare resource service utilization in Shanxi Province.

Taking 11 cities in Shanxi Province as the study object, the fitness between the two was measured using the entropy weight-TOPSIS method and gray correlation analysis.

From the perspective of utilization level, the numerical intervals of breadth and depth of healthcare resource service utilization in Shanxi Province were 0.161-0.751 and 0.000-1.000, respectively, with a wide span of the intervals; from the perspective of protection level, the numerical intervals of breadth, width, and sustainability of outpatient chronic and special disease protection of the basic healthcare insurance in Shanxi Province were 0.761-0.994, respectively, 0.518-0.938 and 0.445-1.000; Taiyuan City had a comprehensive score of 0.734, which was the city with the highest degree of suitability.

This can be done by consolidating the stability of basic medical and healthcare human resources, enhancing the balance of medical resource allocation, strengthening the synergy between the breadth and depth of healthcare insurance coverage, and reinforcing the linkage between healthcare insurance policies and healthcare resources, so as to improve the level of coverage for outpatient chronic and special illnesses under the basic healthcare insurance scheme in Shanxi Province, as well as the level of utilization of healthcare resources and the degree of appropriateness of the two.

To explore the chain mediating roles of adult socioeconomic status and depression in the relationship between childhood friendship experiences and cognitive function in the elderly.

Based on the panel data of China Health and Retirement Tracking Survey (CHARLS) in 2014, 2018, and 2020, Partial correlation analysis was used to explore the correlation among childhood friendship experience, adult socioeconomic status, depression, and cognitive function of the elderly. The SPSS’s Process 4.1macro program was used to analyze the chain mediation effect, and Bootstrap method was used to verify the mediation variables.

The direct effect of childhood friendship experiences on cognitive function in the elderly was significant(β=0.226, 95% CI: 0.109-0.343). The simple mediating effects of adult socioeconomic status and depression between childhood friendship experiences and cognitive function were significant (β=0.095, 95% CI: 0.067-0.126; β=0.023,95% CI:0.009-0.040). The chain mediating effect of adult socioeconomic status and depression between childhood friendship experiences and cognitive function was significant (β=0.006, 95% CI:0.003-0.010). The total mediating effect and the chain mediating effect respectively account for 35.33% and 1.71% of the total effect.

Childhood friendship experience can directly and positively influence cognitive function in the elderly, and also can influence cognitive function in the elderly through the separate and chain mediating effects of socioeconomic status and depression in adulthood.

To investigate the prevalence and influencing factors of insufficient sleep and excessive sleep among Chinese adults from 2010 to 2020, thereby providing a basis for policies aimed atimproving sleep conditions for adults.

Data from the China Family Panel Studies (CFPS) between 2010 and 2020 were utilized. Self-reported nighttime sleep duration was measured, with less than 7 hours classified as insufficient sleep and 9 hours or more classified as excessive sleep. Chi-square tests and Poisson regression models were employed to analyze the frequency and influencing factors.

A total of 9,505 individuals were included in the study. The results indicated that 45.84% of adults reported never experiencing insufficient sleep, while 48.27% of adults reported never experiencing excessive sleep. Poisson regression analysis indicated that females (RR=1.073, 95% CI: 1.028-1.119), increasing age (RR=1.404, 95% CI: 1.305-1.511; RR=1.887, 95% CI: 1.755-2.030; RR=2.092, 95% CI: 1.934-2.263), urban areas (RR=1.219, 95% CI: 1.178-1.260), eastern region (RR=1.346, 95% CI: 1.287-1.409) and central region (RR=1.430, 95% CI: 1.370-1.492), general health (RR=1.114, 95% CI: 1.075-1.154) and unhealthy status (RR=1.164, 95% CI: 1.109-1.221), and higher depression symptom scores (RR=1.018, 95% CI: 1.014-1.022) are risk factors for increased frequency of insufficient sleep. Married/cohabiting (RR=0.894, 95% CI: 0.816-0.980), high school (RR=0.951, 95% CI: 0.904-1.000) and college or above (RR=0.894, 95% CI: 0.828-0.965), BMI<18.5 kg/m² (RR=0.932, 95% CI: 0.871-0.996) are protective factors against increased frequency of insufficient sleep. Aged 30-44 years (RR=0.757, 95% CI: 0.712-0.806) and aged 45-59 years (RR=0.834, 95% CI: 0.783-0.888), married/cohabiting (RR=0.920, 95% CI: 0.847-0.999), junior high school (RR=0.822, 95% CI: 0.789-0.856), high school (RR=0.667, 95% CI: 0.627-0.709) and college or above (RR=0.416, 95% CI: 0.371-0.467), urban (RR=0.737, 95% CI: 0.709-0.766), eastern region (RR=0.698, 95% CI: 0.667-0.730) and central region (RR=0.768, 95% CI: 0.737-0.799) are protective factors against increased frequency of excessive sleep, while unhealthy (RR=1.100, 95% CI: 1.046-1.158) is a risk factor for increased frequency of excessive sleep.

The frequency of insufficient sleep and excessive sleep among Chinese adults is closely related to various sociodemographic factors, physical and mental health conditions, and smoking habits. The government and all sectors of society should prioritize high importance on the sleep conditions of adults and take effective measures to improve sleep health literacy among adult population, ultimately promoting overall health and well-being.

To investigate the effect of subchronic benzo[a]pyrene (BaP) toxicity on tau protein phosphorylation and mild cognitive dysfunction in HAPOE4 mice.

24 male C57BL/6 wild-type and HAPOE4 mice were used in this study, 12 of each type. The mice were randomly divided into three groups: vehicle group (olive oil), low-dose BaP-treated group (2.5 mg/kg), and high-dose BaP-treated group (6.25 mg/kg), with 8 mice in each group. The mice were injected with BaP via the peritoneal cavity and weighed before and after injection. The exposure period was 90 days. The Morris water maze test was used to detect the mice’s learning and memory abilities, the tail suspension test was used to detect the mice’s depressive state, the silver glycinate dip staining was used to observe the neurofibrillary tangles in mouse brain tissue sections, and immunohistochemistry was used to detect the protein expression of APOE, LRP1, tau, p-tau (Ser199), and p-tau (Ser396) in the hippocampus of the mice. ANOVA was used for the comparison of the above count data, the two-sample t-test was used for the comparison between genotypes, and the factorial analysis method was used to verify the interaction between the treatment and genotype.

The results of the water maze behavior experiment: the results of the positioning navigation experiment: the escape latency length of each group decreased with the increase of training days, and the escape latency of HAPOE4 mice with the same dose of poison was higher than that of WT type. There were differences in escape latency between groups on the 4th and 5th days. Both genotype and toxicity could lead to a decrease in the number of crossings of the platform and the residence time in the target quadrant, but there was no significant interaction between genotype and toxicity. The results of tail suspension experiment: genotype and poisoning had an interactive effect on the immobility time of mice, and both of them would lead to an increase in the immobility time of mice. The results of silver glycinate dipping experiment: both genotype and poisoning would cause the dyeing to deepen and increase in mice. The results of immunohistochemistry showed that genotype and poisoning had an interactive effect on the MOD values of APOE, LRP1, tau, p-tau (ser199) and p-tau (ser396), and all of them led to an increase in MOD values.

BaP and APOE4 genes affected spatial learning and memory ability and depression in mice, and BaP and APOE4 genes interacted with the immobility time of tail suspension experiments, indicating that the combined effect of BaP and APOE4 genes may have an effect on the depressed state of mice; and BaP and APOE4 genes interacted with abnormal phosphorylation of tau protein in mice, indicating that subchronicBaP infection could lead to tau protein phosphorylation and mild cognitive dysfunction in mice with HAPOE4 genotype, which may be caused by the combined effect of BaP and APOE4 genes resulting in the increase of APOE and LRP1 in mice.