PDF
Full
Outline
To explore the causal relationship between age-related hearing loss and Alzheimer’s disease through two-sample Mendelian randomized analysis.
Inverse variance weighted, MR-Egger regression, weighted median, simple model, and weighted model were used to evaluate the relationship between age-related hearing loss and the risk of Alzheimer’s disease. Sensitivity analysis (pleiotropy, heterogeneity, and leave-one-out test) was used to evaluate the robustness of the results.
Statistical results showed that there was no causal association between age-related hearing loss and Alzheimer’s disease (inverse variance weighting method: OR=1.0526, 95%CI: 0.7155-1.5485; MR-Egger: OR=1.1347, 95%CI:0.2123-6.0660; weighted median method: OR=0.8908, 95%CI: 0.5281-1.5025; simple model method: OR=0.7157, 95%CI:0.2505-2.0445; weighted model method: OR=0.7470, 95%CI: 0.3153-1.7698). These results were consistent with that of Alzheimer’s disease proxy cases (inverse variance weighting method: OR=0.9560, 95%CI: 0.9008-1.0146; MR-Egger: OR=0.9887, 95%CI: 0.7729-1.2647; weighted median method: OR=0.9487, 95%CI: 0.8752-1.0283; simple model method: OR=0.9597, 95%CI: 0.8147-1.1305; Weighted model method: OR=0.9632, 95%CI: 0.8298-1.1179). Sensitivity analysis showed that there was no significant heterogeneity or pleiotropy, indicating that the results were robust.
There is no evidence that age-related hearing loss is associated with an increased risk of Alzheimer’s disease.
PDF
39
17
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
