PDF
Full
Outline
To explore the relationship between hormone replacement therapy (HRT) and the time period when postmenopausal women received HRT and accelerated biological aging.
Based on the biochemical and anthropometric data collected from the UK Biobank baseline survey, the biological age (BA) and BA acceleration index were constructed by Klemera Doubal method (KDM). The subjects were divided into 5 groups according to the status of receiving HRT: no, 10 years before menopause, 0-10 years before menopause, 0-10 years after menopause, and 10 years after menopause. Multivariate linear regression model was used to explore the relationship between HRT and BA acceleration. The characteristic factors of the population were taken as stratified factors for stratified analysis.
A total of 96 889 subjects were included. Compared with people who did not receive HRT, there was a correlation for starting HRT 0-10 years before menopause (β=-0.28, 95%CI:-0.36 to -0.19) and starting HRT postmenopausal 0-10 years (β=-0.39, 95%CI: -0.46 to -0.31) with the delayed accelerated aging. The effect of HRT on delaying and accelerating aging was more obvious in postmenopausal women less than 60 years old.
Receiving HRT slows biological aging and is more effective when used within 10 years of menopause in postmenopausal women under 60 years of age.
PDF
79
35
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
