Objective This study investigates potential relationships between distinct physical activity patterns and metabolic syndrome (MS) to provide evidence for exercise-based prevention and control of MS. Methods Utilising data from 15 338 US adults in NHANES 2011—2020, participants were stratified into physical activity patterns. Metabolic syndrome (MS) was diagnosed via NCEP-ATP III criteria. Multivariable logistic regression evaluated associations between activity patterns and MS risk. Restricted cubic splines(RCS) were used to model dose-response relationships, and subgroup analyses were conducted. Results Compared with inactive individuals, both weekend warriors (aOR=0.856, 95% CI: 0.736-0.995) and regular exercisers(aOR=0.758, 95% CI: 0.690-0.833) exhibited significant inverse associations with MS risk. RCS analysis demonstrated a progressive reduction in MS risk with increasing total physical activity duration (P≤0.001). Subgroup analyses revealed enhanced protective effects for weekend warriors among adults aged >60 years(aOR=0.679, 95% CI: 0.518-0.887) and males(aOR=0.792, 95% CI: 0.639-0.979). In the regular exercise group, increases in activity duration, intensity, and frequency were significantly associated with lower MS risk. Conclusion This study demonstrates that both regular exercise and weekend warrior physical activity patterns correlate with reduced metabolic syndrome risk, highlighting the importance of physical activity in comprehensive MS prevention and intervention strategies.

Objective To describe the burden of type 2 diabetes mellitus attributable to low physical activity in China from 1990 to 2021 and to predict its trend between 2022 and 2035, and to provide a basis for the formulation of related prevention and control policies. Methods According to the relevant data from the Global Burden of Disease Study 2021, the burden of disability-adjusted life years (DALYs) and mortality for type 2 diabetes mellitus attributable to low physical activity were comparatively analyzed in China and globally using the Estimated Annual Percentage Change (EAPC). Changes in DALYs and mortality burden in China were analyzed using decomposition analysis, and trends were predicted by a Bayesian age-period-cohort model. Results Compared with 1990, DALYs, mortality, age-standardized DALYs rate (ASDR), and age-standardized mortality rate(ASMR) for type 2 diabetes mellitus attributable to low physical activity increased in China in 2021, and the burden was lower than the global level. The EAPC values for ASDR and ASMR in China were 0.63% and 0.02%, respectively, indicating stable trends. Older adults and females experienced a more severe burden. Aging and population growth were significant driving factors for changes in the burden of DALYs and mortality in China. It was predicted that from 2022 to 2035,ASDR for males and females in China would show an upward trend, with ASMR exhibiting a downward trend. Conclusion To reduce the burden of type 2 diabetes attributable to low physical activity, more proactive and comprehensive interventions should be developed to increase the level of physical activity in the entire population, especially for older adults and females.

Objective To empirically study the core competences evaluation index system for the doctor of public health (DrPH) in China, and to test its discriminant ability, reliability and validity. Methods This study designed the corresponding questionnaire in March 2025. The stratified cluster sampling method was used to select 200 doctors of public health who were enrolled from 2021 to 2024 to conduct a questionnaire survey in China. Cronbach’s α coefficient was used to assess reliability.Pearson correlation analysis assessed internal consistency. T test and F test assessed discriminant validity. Exploratory factor analysis assessed structural validity. Results A total of 189 questionnaires were retrieved. There were 189 valid questionnaires.The effective rate of questionnaire was 100%. The overall Cronbach’s α coefficient of the ability evaluation index system was 0.969, the Cronbach’s α coefficient of the basic knowledge dimension was 0.691, and the Cronbach’s α coefficient of other dimensions were above 0.8. The correlation coefficient between each dimension and the total score was between 0.5 and 0.9.There were statistically significant differences in core competence scores of public health doctors in different grades, public health practitioner certificates, public health practice experience and parents’ occupations (P<0.05). KMO value was 0.916,Bartlett’s spherical test value P<0.001, six common factors were extracted, and the total contribution rate of factor variance was 69.9%. Common factors could basically reflect the core concepts and main dimensions of the evaluation index system for the core competence of doctors in public health. Conclusion The core competences evaluation index system for the DrPH demonstrates good reliability and validity, indicating that it can serve as a tool for the training, evaluation, and assessment of the core competences for the DrPH.

Objective To establish a method for the rapid detection of 15 N-nitrosamines in bacon by enhanced matrix removal dispersive solid phase extraction combined with gas chromatography-tandem mass spectrometry (GC-MS/MS). Methods The samples were extracted with acetonitrile oscillation, frozen for 30 minutes, and then centrifuged at low temperature. The extract was further purified using an enhanced lipid removal purification tube (QuEChERS EMR-lipid) and an EMR-lipid stripping tube. The N-nitrosamines were separated on a polar capillary column, detected in the multiple reaction monitoring (MRM) mode and quantified by the matrix-matched external standard method. Results The linear correlation coefficients of the method were greater than 0.990 in the range of 0.2-40.0 μg/L, with the detection and quantification limits of 0.03-0.30 and 0.1-1.0 μg/kg, respectively. The recoveries were 64.1%-106.1% at three spiked levels (2.0, 5.0, 10.0 μg/kg)，with the relative standard deviations (RSDs) ranging from 3.48% to 14.55%. Conclusion The method does not require activation, equilibration, or elution steps, consumes less solvent, is simple and rapid, and is suitable for the rapid detection of 15 N-nitrosamines in bacon.

Objective To analyze the awareness of nutritional health knowledge among school-age children in Sichuan Province, identify shortcomings and related issues of nutritional health knowledge, and provide a scientific basis for nutritional intervention policies. Methods From October 2023 to May 2024, a multi-stage sampling method was used to collect nutritional health knowledge questionnaires from 12 674 school-age children in 21 districts and counties of Sichuan Province through a questionnaire survey. Descriptive statistical analysis and multivariable analysis were conducted based on survey content. Results The nutritional health knowledge scores [median (interquartile range)] of school-age children in Sichuan Province (including lower elementary school students) in 2023—2024 were 73.00 (63.00-84.00). Scores for lower elementary, upper elementary, middle school, and high school groups were 90.00 (80.00-95.00), 72.00 (62.00-82.00), 69.00 (58.00-77.00), and 66.00 (57.00-74.00), respectively. The higher the grade level, the lower the score, and this was statistically significant. The score rate ranges for the five knowledge dimensions of dietary recommendations, food classification and characteristics, food and growth development and health, food selection, and food safety were 54.82%-81.66%, 60.31%-91.40%, 69.85%-89.50%,71.65%-86.20%, and 69.38%-84.07%, respectively. The lower elementary school grade group had the highest score in each knowledge dimension, and the senior high school group had the lowest score rate. The awareness rate (excluding lower elementary grades) was 32.98%, and the awareness rates for upper elementary school grades, middle school, and high school were 41.91%, 31.12%, and 23.34%, respectively. The higher the grade level, the lower the awareness rate, and this was statistically significant (χ²=249.432, P<0.001). Univariate analysis results showed that gender, grade level, region, whether living on campus, the educational level and occupation of the parents of school-age children had statistically significant differences in the awareness rate of nutritional health knowledge (P<0.05). Logistic regression analysis results showed that the grade level, region (urban or rural), whether living on campus, father’s education and occupation were important factors affecting the awareness level of nutritional health knowledge among school-age children in Sichuan Province. Conclusion There is significant room for improvement in the awareness rate of nutritional health knowledge among school-age children in Sichuan Province. To improve the nutritional health literacy of school-age children, it is necessary to further strengthen the publicity and education of nutritional health knowledge.

Objective To understand the economic burden of hospitalized cases of mycoplasma p neumonia (MPP) in Wuhan in 2023, and to provide a scientific basis for the formulation and improvement of public health prevention and control policies. Methods A questionnaire survey was conducted on the hospitalized cases of MPP in Wuhan from January to October 2023. Non-parametric tests were used to analyze the differences in direct, indirect, and total economic burden among different groups of patients due to MPP. Multivariable Logistic regression was used to analyze the related factors affecting economic burden. Results A total of 342 cases of hospitalized MPP were investigated. The total economic burden was higher in severe cases and those with symptoms of fever, cough, and headache (P<0.001). Seeking medical treatment at a tertiary general hospital in a remote urban area (OR=0.156, 95% CI: 0.032-0.764), being aged 19-59 years (OR=13.706, 95% CI: 4.697-39.999), being aged ≥60 years (OR=57.661, 95% CI: 13.283-250.315), hospitalization lasting more than 7 days (OR=3.244, 95% CI: 1.624-6.479), and caregivers missing work for more than 7 days (OR=8.323, 95% CI: 4.108-16.862) were identified as factors associated with the total economic burden (P<0.05). Conclusion Visiting a children’s specialized hospital, severe cases, having symptoms of fever, cough, and headache, increasing age, length of hospital stay, and days of caregiver’s lost work all bring heavier economic burdens to patients. Public health policy interventions such as strengthening clinical diagnosis and treatment, and improving the medical security system should be strengthened to reduce the economic burden on patients.

Objective This study investigates the mediating effects of general self-efficacy and social participation on the relationship between physical function and physical resilience (PR) among older adults. Methods The elderly in five communities selected by cluster sampling in Xinxiang City were surveyed using the Simplified Physical Fitness Test Scale,Physical Resilience Scale, General Self-Efficacy Scale, and the Social Participation Scale from March to November 2024.Descriptive statistics, variance analysis, and correlation analysis were conducted, and a chain mediation effect model was constructed using Mplus 8.3. Results A total of 1 071 elderly people in the community were surveyed, the PR score of the elderly in the community was (48.81±5.66), and the PR of the elderly was positively correlated with physical function, general self-efficacy, and social participation (all P<0.05). After including control variables such as age, sleep duration, and living arrangement, general self-efficacy and social participation played a chain mediating effect between physical function and PR,with a mediating effect value of 0.311, accounting for 55.24% of the total effect. Conclusion Physical function in the elderly can directly affect PR, and can also indirectly affect PR through general self-efficacy and social participation. The PR of older adults can be improved by improving their physical functioning, self-efficacy, and social participation.

Objective To investigate the association between the dietary index for gut microbiota (DI-GM) and metabolic syndrome (MetS), thereby providing a theoretical basis for preventing MetS through dietary modulation of the gut microbiome. Methods Data from 17 558 adults participating in the 2007—2018 U.S. National Health and Nutrition Examination Survey (NHANES) were analyzed, with MetS determined according to the NCEP ATP III criteria. The DI-GM score was constructed based on 14 food items or nutrients obtained from two 24 hour dietary recalls. Logistic regression models and restricted cubic spline (RCS) analysis were used to evaluate the relationship between DI-GM and MetS, and subgroup as well as sensitivity analyses were conducted. Results In the fully adjusted model, the risk of MetS decreased with increasing DI-GM scores (OR=0.94, 95% CI: 0.91-0.98). Specifically, individuals in the highest DI-GM quartile (Q4) had an 18% lower risk of MetS than those in the lowest quartile (OR=0.82, 95% CI: 0.72-0.95). RCS analysis indicated a linear inverse dose-response relationship between DI-GM and MetS (P for nonlinear=0.185). Subgroup analyses showed the inverse association was stronger in females, non-Hispanic Black individuals, and those with higher education levels(P for interaction<0.05). Sensitivity analyses confirmed the stability of the results(OR=0.94, 95% CI: 0.90-0.98). Conclusion This study demonstrates that maintaining a diet favorable to gut microbiota health can reduce the risk of MetS. These findings suggest that improving dietary patterns to modulate the gut microbiome may offer a novel strategy for the prevention and management of MetS.

Vaccination is one of the most effective measures for preventing infectious diseases. However, in recent years, vaccine hesitancy has become increasingly prominent, and the World Health Organization has identified it as one of the “top ten threats to global health” in 2019. Some developed countries have formulated targeted interventions by identifying the influencing factors of vaccine hesitancy. In contrast, systematic research on vaccine hesitancy in China remains limited.Therefore, this review aims to summarize the influencing factors of vaccine hesitancy reported both domestically and internationally, in order to provide a theoretical foundation for developing intervention strategies in China.

Objective Aging is a common starting point for many diseases, and homeostatic dysregulation (HD) is an important intervention indicator of aging. This study investigates the association between Tibetan noodle consumption and HD. Methods Using baseline survey data from the China Multi-Ethnic Cohort study (CMEC), HD was constructed on the basis of clinical biomarkers and anthropometric indices. Dietary information was obtained from the Food Frequency Questionnaire (FFQ). Multivariable linear regression analysis was used to explore the association between Tibetan noodle consumption and HD.Stratified analyses were conducted by sex, age, and BMI to explore the heterogeneity of the association effect. Results A total of 4 485 study participants were included. Compared with non-consumption of Tibetan noodles, a weekly consumption frequency of more than 7 times was associated with lower HD (β=-0.304, 95% CI: -0.593~-0.015). Similarly, a weekly intake exceeding 1 050 grams of Tibetan noodles demonstrated reduced HD (β=-0.130, 95% CI: -0.245~-0.014). Additionally, sex might act as a potential effect modifier. Conclusion Tibetan noodle consumption was inversely associated with HD, suggesting that consumption of Tibetan noodles, a specialty diet, has potential value in improving HD and slowing down aging.