To investigate the application of acupuncture combined with sports acupuncture in the treatment of chronic ankle synovitis based on the theory of " Treating Lower Diseases by Acting on the Upper Body".

98 patients with chronic ankle synovitis admitted to the Department of Soft Tissue Injury of Sichuan Orthopedic Hospital from September 2024 to April 2025 were selected and divided into two groups using the random number method, each with 49 cases. The control group was given conventional treatment, and the treatment group was treated with the 'lower disease upper treatment' theory of acupuncture combined with sports acupuncture for two consecutive weeks. Clinical efficacy, Visual Analog Scale (VAS) scores, degree of ankle swelling, most painful point, pain threshold, ankle joint range of motion, American Orthopaedic Foot and Ankle Society (AOFAS) scores were compared between the two groups.

Treatment group had a higher clinical efficacy rate in contrast to control group (P < 0.05). After treatment, the VAS score, degree of ankle joint swelling and pain threshold in both groups decreased compared with those before treatment, while the AOFAS score and range of motion of the ankle joint increased compared with those before treatment (P < 0.05). Compared with the control group, the treatment group exhibited lower VAS scores, reduced ankle swelling, and lower pain thresholds, while demonstrating higher AOFAS scores, greater ankle range of motion, and a higher number of patients with improvement in the most painful point (P <0.05).

Under the guidance of the " treating the lower disease from the upper" theory, acupuncture combined with sports acupuncture therapy can effectively relieve the pain and swelling symptoms of patients with chronic ankle synovitis, promote the recovery of joint function, and significantly improve the therapeutic effect.

To observe the treatment of patients with wind-cold type peripheral facial palsy using acupuncture combined with bloodletting therapy based on meridian sinew theory.

A total of 120 patients with wind-cold type peripheral facial palsy treated at the Acupuncture and Physiotherapy Department of Zhengzhou Central Hospital from May 2022 to May 2024 were enrolled. They were randomly divided into an acupuncture group (sinew acupuncture therapy) and a combination group (sinew acupuncture combined with bloodletting at Yifeng acupoint), with 60 cases in each group. The acupuncture group received sinew acupuncture based on meridian sinew theory, with acupoint selection including: Quanliao (SI18), Cuanzhu (BL2), Sibai (ST2), Yangbai (GB14), Taiyang (EX-HN5), Dicang (ST4), Jiache (ST6), and Hegu (LI4). Subcutaneous longitudinal and transverse shallow needling was performed. In the combination group, in addition to the acupuncture points used in the acupuncture group, bloodletting therapy at Yifeng (TE17) was performed. The area around Yifeng acupoint was clamped with the thumb, index, and middle fingers of the left hand, pricked several times, followed by cupping on the pricked area. Five consecutive days of treatment constituted one course, with a 2-day interval between courses. A total of two courses were administered. After the two courses of treatment, the House-Brackmann (H-B) grading scale, Facial Disability Index (FDI), Portmann scale for peripheral facial neuritis, blink reflex, and facial electromyography parameters were observed in both groups before and after treatment to evaluate and compare the clinical efficacy.

After treatment, the FDI scale scores showed that the improvement in the physical function dimension (FDIP) score was significantly greater in the combination group than in the acupuncture group, while the decrease in the social function dimension (FDIS) score was more pronounced in the combination group, with statistically significant differences (P <0.05), indicating that the combined therapy had superior comprehensive improvement in patients' physiological function and social adaptability. The Portmann scale scores showed that the combination group had significantly higher scores than the acupuncture group (P < 0.05), indicating better improvement in facial nerve function in the combination group. The latencies of the orbicularis oris muscle, orbicularis oculi muscle, and nasalis muscle were significantly shortened in both groups compared with before treatment (P < 0.05). The latencies of the orbicularis oris muscle, orbicularis oculi muscle, and nasalis muscle in the combination group were significantly shorter than those in the acupuncture group (P <0.05). After treatment, the latencies of R1, R2, and contralateral R2' waves in both groups were significantly shorter than those before intervention, and the combination group showed significantly shorter latencies than the acupuncture group, with statistically significant differences (P <0.05), indicating that the combination group had better efficacy in repairing facial nerve function.

Acupuncture combined with bloodletting therapy based on meridian sinew theory can effectively improve the clinical symptoms of patients with wind-cold type peripheral facial palsy. Both treatments have significant efficacy in patients with wind-cold type peripheral facial palsy, but the combination of sinew acupuncture and bloodletting at Yifeng acupoint is superior to acupuncture alone. This combined therapy can reduce nerve inflammation, improve local blood circulation, repair damaged nerve fibers, regulate nerve excitability, better promote the recovery of facial nerve function.

To analyze the effects of Sihuang Shengji decoction on serum activin A (AC-TA), interleukin-1 α (IL-1α), and platelet-derived growth factor (PDGF) after perianal abscess surgery with damp-heat toxicity accumulation.

176 patients with perianal abscess who were treated by surgery in the Fourth People's Hospital of Jinan from December 2022 to December 2024 were selected and randomly divided into routine group and decoction group, with 88 cases in each group. Conventional group: Received conventional postoperative treatment. Decoction group: On the basis of the control group, Sihuang Shengji Decoction was used for treatment. Evaluate the level of TCM syndrome scores of patients; Calculate the improvement time of symptoms in the two groups; The degree of pain of the patients was evaluated by using the VAS score scale. The anal function of the patients was evaluated using the Wexner scoring scale; Detect the maximum systolic pressure of the anal canal and the resting pressure of the anal canal; Detect the levels of VEGF, TGF-β1, SOD, MDA, AC-TA, IL-1α and PDGF. Compare the clinical effective situation.

After treatment, compared with the conventional group, TCM syndrome score, Wexner score, VAS score, MDA, AC-TA, IL-1 α level were decreased (P < 0.01) ; maximum anal tube systolic pressure, anal resting pressure, VE GF, TGF-β1, SOD, and PDGF levels were increased (P < 0.01) ; improvement time of symptoms in the decoction group was shortened (P <0.01) ; total response rate increased in the decoction group (P < 0.01). The incidence of adverse reactions in the decoction group was higher than that in the conventional group (P > 0.05).

For postoperative patients with perianal abscess caused by damp-heat toxicity accumulation, the treatment with Sihuang Shengji decoction can reduce the level of TCM syndrome score, improve anal function, and regulate the levels of serum AC-TA, IL-1α, and PDGF, with remarkable clinical effects.

To observe the clinical efficacy and safety of self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological regulators in the treatment of rheumatoid arthritis.

A prospective cohort study was conducted on 120 patients with rheumatoid arthritis admitted to Xinyang Central Hospital from January 2022 to January 2025, using a random number table method. Both groups received leflunomide tablets. The conventional group was treated with intestinal microecological modulators, while the combined group received self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological modulators. Microbiome diversity metrics (evenness and richness), anti-cyclic citrullinated peptide (CCP) antibody levels, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured in both groups. Clinical efficacy outcomes were statistically analyzed.

There was no difference in the uniformity and richness of the microbiome flora between the two groups before treatment (P >0.05). Before and after treatment, the uniformity and richness of the microbiome in both groups increased, and the uniformity and richness of the microbiome in the comprehensive group after treatment were higher than those in the conventional group (P <0.05). There was no difference in the relevant scores between the two groups before treatment (P >0.05). Before and after treatment, the scores of the Arthritis Quality of Life Scale 2 (AIMS2-SF) in both groups increased, and the comprehensive group was higher than the conventional group after treatment (P < 0.05). The TCM symptom scores, DAS28 scores and VAS scores of both groups decreased, and the comprehensive group was lower than the conventional group (P < 0.05). There was no difference in anti-CCP antibody, ESR and CRP between the two groups before treatment (P > 0.05). Before and after treatment, the anti-CCP antibody, ESR and CRP in both groups decreased, and the comprehensive group was lower than the conventional group after treatment (P <0.05). The improvement rate of ACR20 in the comprehensive group was 61. 67%, which was higher than 43. 33% in the conventional group. The improvement rates of ACR50 and ACR70 were 46. 67% and 15. 00% respectively, and there was no difference compared with 31. 67% and 6. 67% in the control group (P >0.05).

The Self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological regulators in the treatment of rheumatoid arthritis can reduce the levels of anti-CCP antibody, ESR and CRP, alleviate symptoms.

To explore the efficacy of Qutan Huayu Tongbi Decoction combined with VRD regimen in the treatment of multiple myeloma (MM) with phlegm-stasis obstructing collateral syndrome.

A prospective randomized controlled placebo study was conducted, enrolling 132 MM patients with phlegm-stasis obstructing collateral syndrome admitted to the Department of Hematopathy of Qingyang Traditional Chinese Medicine Hospital from January 2022 to December 2024. Patients were randomly divided into two groups using a random number table. The control group (66 cases) received VRD chemotherapy combined with Chinese medicine placebo, while the observation group (66 cases) received VRD chemotherapy combined with Qutan Huayu Tongbi Decoction. Both groups were treated continuously for 4 cycles. The chemotherapy efficacy, TCM syndrome score, degree of bone pain, quality of life, blood biochemistry, coagulation indicators and adverse reactions were compared between the two groups.

The DCR (95. 45% vs 63. 63%), ORR (81. 82% vs 51. 52%), and the total effective rate of traditional Chinese medicine (93. 94% vs 77. 27%) in the observation group were all higher than those in the control group (P <0.01), while the overall incidence of adverse reactions was lower (7. 58% vs 22. 73% , P <0.05). After treatment, both groups showed a decrease in TCM syndrome score, bone pain Visual Analog Scale (VAS) score, and levels of vascular endothelial growth factor (VEGF), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte ratio (NLR), bone marrow plasma cell proportion, β2-microglobulin (β2-MG), lactate dehydrogenase (LDH), serum creatinine (Scr), blood urea nitrogen (BUN), D-dimer (D-D), and plasma fibrinogen (FIB) compared to before treatment (P < 0.01), with the observation group showing lower values than the control group (P < 0.01). The lymphocyte-to-monocyte ratio (LMR), hemoglobin (Hb), Karnofsky Performance Status (KPS) score, and Activities of Daily Living (ADL) score increased compared to before treatment (P < 0.05), with the observation group showing higher values than the control group (P <0.01). Prothrombin time (PT) and activated partial thromboplastin time (APTT) were prolonged compared to before treatment (P < 0.01), with the observation group showing longer times than the control group (P < 0.01).

The combination of Qutan Huayu Tongbi Decoction and VRD chemotherapy regimen can effectively enhance the therapeutic effect of chemotherapy for multiple myeloma, alleviate clinical symptoms, bone pain and anemia, improve coagulation and renal functions, regulate immune inflammation, enhance the physical condition and quality of life of patients, and has good safety.

A total of 82 elderly patients with hypertension complicated by heart failure and deficiency of qi-blood, as well as restlessness of the mind were selected from Henan Provincial Veterans' Hospital from January 2022 to January 2024. They were divided into the control group and the treatment group according to the random number table method, with 41 cases in each group. Both groups were given symptomatic treatment. The control group was treated with valsartan, while the treatment group was treated with Yangxin Decoction combined with valsartan. Both groups were given continuous treatment for 8 weeks. The cardiac function indicators, blood pressure, TLR4/Macrophage Differentiation Factor 88 (MyD88)/Nuclear Factor-κB (NF-κB) pathway factors, C1q Tumor Necrosis Factor-related Protein 3 (CTRP3), N-terminal Brain Natriuretic Peptide precursor (NT-proBNP), Troponin I (cTnI), and high-sensitivity C-reactive protein (hs-CRP) levels were compared between the two groups, and the incidence of adverse reactions was statistically analyzed.

There was no significant difference in the pre-treatment cardiac function indicators, blood pressure, CTRP3, BNP, cTnI, and hs-CRP between the two groups (P >0.05). After treatment, the left ventricular ejection fraction (LVEF), CTRP3, and the ratio of early to late diastolic filling velocity (E/A) in both groups increased compared with those before treatment, while blood pressure, BNP, left ventricular end-systolic diameter (LVESD), cTnI, hs-CRP, and left ventricular end-diastolic diameter (LVEDD) decreased (P <0.05). The LVEF and E/A in the treatment group were higher than those in the control group after treatment, while LVESD and LVEDD were lower (P < 0.05). There was no significant difference in the TLR4/MyD88/NF-κB pathway factors before treatment between the two groups (P > 0.05). After treatment, the relative expression levels of TLR4, MyD88, and NF-κB in both groups decreased compared with those before treatment (P < 0. 05). The relative expression levels of TLR4, MyD88, and NF-κB in the treatment group were lower than those in the control group after treatment (P <0.05). There was no significant difference in the cumulative incidence of adverse reactions between the two groups (P > 0.05).

The combination of Yangxin Decoction and Valsartan can regulate the TLR4/MyD88/NF-κB signaling pathway in elderly patients with hypertension, improve cardiac function, lower blood pressure, and does not increase adverse reactions.

To study the effects of Modified Yulin Zhu combined with warm acupuncture on endometrial receptivity and serum leukemia inhibitory factor (LIF) vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) levels in patients with thin endometrium of renal deficiency and blood stasis type.

84 patients with thin endometrium (renal deficiency and blood stasis type) admitted to Taizhou Hospital of Traditional Chinese Medicine from January 2023 to September 2024 were selected, the grouping method was random number table method, the patients were divided into control group (treated with estradiol tablets/estradiol dydrogesterone tablets composite packaging, 42 cases) and observation group (treated with Modified Yulin Zhu and warm acupuncture on the basis of control group, 42 cases), the clinical efficacy, traditional Chinese medicine syndrome score, menstrual blood volume score, endometrial receptivity, serum LIF, VEGF, MMP-9 and incidence of adverse reactions were compared between two groups.

The total clinical effective rate of the observation group was higher than that of control group (P <0.05). Traditional Chinese medicine syndrome score in observation group were lower than those in control group 3 months after treatment, the endometrial thickness was greater than that in control group, and menstrual blood volume score, serum LIF, MMP-9 and VEGF were higher than those in control group (P <0.01). There was no difference in the incidence of adverse reactions between the observation group and the control group (P > 0.05).

Modified Yulin Zhu combine with warm acupuncture treatment, which can improve the clinical symptoms of patients with thin endometrium of renal deficiency and blood stasis type, and regulate endometrial receptivity, which may be relate to the improvement of serum LIF, VEGF and MMP-9 levels.

To analyze the effects of early limb rehabilitation training combined with traditional Chinese medicine fumigation on patients with hemiplegia after cerebral infarction (Cerebral Infarction, CI).

A retrospective analysis was conducted on the clinical data of 128 patients with hemiplegia after CI from October 2022 to October 2024. Among them, 64 patients received conventional treatment and rehabilitation training as the control group, while another 64 patients underwent early limb rehabilitation training combined with traditional Chinese medicine fumigation as the study group. The cerebral circulation hemodynamics indicators of both groups were analyzed, and assessments were performed using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Fugl-Meyer Assessment (FMA), Functional Composite Assessment (FCA), and Berg Balance Scale (BBS).

Before treatment, there were no statistically differences in cerebral circulation hemodynamics indicators between two groups (P > 0.05). After treatment, the study group higher minimum blood flow velocity and minimum blood flow volume compared to the control group(P < 0.01), along with significantly higher critical pressure and cerebrovascular peripheral resistance (P <0.05). Before treatment, there were no significant differences in MoCA and MMSE scores between two groups (P >0.05). After treatment, the study group showed higher MoCA and MMSE scores (P <0.05, P < 0.01). Before treatment, there were no significant differences in limb motor function between two groups (P > 0.05). After treatment, the study group demonstrated higher upper and lower limb motor function scores (P <0.01). Before treatment, there were no significant differences in motor balance function between two groups (P > 0.05). After treatment, the study group higher FCA and BBS scores (P < 0.01).

Early limb rehabilitation training combined with traditional Chinese medicine fumigation yields favorable outcomes for patients with hemiplegia after CI, not only improving cognitive function and mental state but also enhancing limb motor function and motor performance, while also contributing to the stabilization of cerebral circulation hemodynamics indicators.

Investigating the Clinical Efficacy of a self-formulated Jianpi Chuji Formula in Alleviating Toxic Side Effects Following Immune Checkpoint Inhibitor (ICI) Therapy in Advanced Non-Small Cell Lung Cancer Patients.

A total of 98 patients with advanced non-small cell lung cancer (NSCLC) who received immunotherapy (ICIs) at Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province from May 2019 to May 2021 were enrolled as study subjects. They were randomly divided into a control group (n=49) and a treatment group (n = 49). The control group received immune checkpoint inhibitor therapy combined with a platinum-based dual-drug regimen. The treatment group received the same regimen supplemented with self-formulated Jianpi Chuji Formula. Changes in thyroid function indicators, Traditional Chinese Medicine (TCM) syndrome scores, Karnofsky Performance Status (KPS), carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), adverse reaction incidence, and clinical efficacy were compared between the two groups.

Following treatment, both groups exhibited elevated levels of thyroid-stimulating hormone (TSH) and KPS scores. Symptoms including fatigue, skin keratosis, pain, limb numbness, sallow complexion, pulse, dark tongue, total score, total thyroxine (TT₄), free triiodothyronine (FT₃), free thyroxine (FT₄), CYFRA21-1, and CEA levels decreased in both groups, with greater improvement observed in the treatment group compared to the control group (P < 0. 01). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P >0. 05). Compared to the control group, the treatment group demonstrated higher objective response rates (ORR) and disease control rates (DCR) (P <0. 01). Multivariate analysis showed that age and pathological type had no significant effect on treatment response (P >0. 05) ; After 6 months of follow-up, progression-free survival was better in the treatment group than that in the control group (P <0.05).

Treatment with self-formulated Jianpi Chuji Formula in non-small cell lung cancer patients following ICIs therapy demonstrated significant efficacy. This approach effectively improved patients' quality of life, reduced tumor marker levels, enhanced thyroid function, and decreased the incidence of toxic side effects.