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Outline
To investigate the mechanism by which total flavonoids of Lizhihe（Lichi Semen）（TFL）inhibiting NLRP3 inflammasome activation and attenuating hepatic fibrosis in rats.
Hepatic fibrosis in rats was caused by subcutaneous injection of 40% carbon tetrachloride（CCl4），and the rats were randomly divided into a blank group，a model group，a Fuzheng Huayu Capsule（扶正化瘀胶囊）group（450 mg/kg），a TFL high-dose group（180 mg/kg），a TFL medium-dose group（90 mg/kg）and a TFL low-dose group（45 mg/kg）according to their body weights. After 8 weeks of gavage administration，the fibrotic lesions of liver tissue were observed by Masson staining，and the levels of tissue inhibitor of metalloproteinase-1（TIMP-1），matrix metal oproteinase-2（MMP-2）and reactive oxygen species（ROS）in liver tissue were detected. The expressions of thioredoxin interacting protein（TXNIP），NOD-like receptor thermal protein domain associated protein 3（NLRP3），Caspase-1 and interleukin-1β（IL-1β）proteins in liver tissue were determined by Western blotting.
Each dose of TFL attenuated the degree of hepatic tissue fibrosis in rats and significantly reduced the hepatic fibrosis grade（P<0.05），and the hepatic tissue levels of TIMP-1 and MMP-2 were significantly decreased in each dose group of TFL（P<0.05）. What's more，all doses of TFL significantly reduced the liver tissue ROS level（P<0.01），and decreased the expressions of TXNIP，Caspase-1 and IL-1β proteins（P<0.05）.
TFL significantly attenuated CCl4-induced hepatic fibrosis in rats，and the mechanism may be related to the reduction of hepatic ROS accumulation，which inhibits the activation of NLRP3 inflammatory vesicles.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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