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Outline
Kaempferide, as one of the active ingredients in many traditional Chinese medicines, has a wide range of pharmacological effects in various systems. Its mechanisms include inhibiting the proliferation of cancer cells by inducing apoptosis; exerting a neuroprotective effect by increasing the concentration of brain-derived neurotrophic factor and alleviating oxidative stress responses; reducing oxidative stress responses by enhancing the expression of antioxidant genes and inhibiting the release of reactive oxygen species; resisting photoaging by inhibiting the expressions of pro-inflammatory factors, playing a protective role in the heart by exerting anti-inflammatory, antioxidant and anti-apoptotic effects; protecting the kidneys by inhibiting the overexpression of HMGCS2 in renal tubular epithelial cells and alleviating renal interstitial fibrosis. This article comprehensively summarized the pharmacological effects and mechanism studies of kaempferide based on relevant literature in recent years, aiming to provide a theoretical basis for the further development of kaempferide into a monomer drug.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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