To analyze the influencing factors and improvement paths of the service capacity of standardized township health centers in Guangxi under the background of "high-quality service at the grassroots level", providing useful reference for further deepening reform and promoting the healthy development of rural medical and health systems.

By the end of 2021, township health centers that have reached the recommended standard of "quality service primary line" service ability were selected as the research samples, and the coupled coordination degree model was combined with fuzzy set qualitative comparative analysis method to carry out empirical analysis.

Single factors cannot constitute a necessary condition for improving or decreasing the service capacity of township health centers. There are a total of four configuration paths for improving the service capacity of township health centers in Guangxi, among which the core sufficient conditions for playing a leading role are the number of high-level practicing (assistant) physicians, the number of registered nurses, and coupling coordination scheduling. The overall consistency of the solution is 0.920 (≥0.8), and the model has strong explanatory power.

The improvement of service capacity in township health centers in Guangxi is facilitated by the synergistic effect of multiple factors both internally and externally. The optimization and expansion of grassroots talent teams is the core combination element for the improvement of service capacity in township health centers, and the coupling and coordinated development of medical resource allocation and economy is the key element for the improvement of service capacity.

To investigate the relationship between muscle strength and the risk of depression in the middle-aged and elderly, and to provide reference for the prevention and treatment of depression in the middle-aged and elderly in China.

Based on the data of China Health and Retirement Longitudinal Study (CHARLS), the middle-aged and elderly people who participated in the survey in 2015 and 2018 were selected. Firstly, restricted cubic splines (RCS) were used to analyze whether there was a dose-response relationship between upper limb strength (standardized grip strength) and lower limb strength (time to stand up from a chair) and the risk of depression in the middle-aged and elderly. Secondly, the upper and lower limb strength were divided into three groups, and Logistic regression model was used to evaluate the correlation between upper and lower limb strength, overall muscle strength and depression risk in the middle-aged and elderly.

A total of 6 245 subjects were enrolled in this study. During the 3-year follow-up period, a total of 2 095 (33.5%) subjects had depressive symptoms.There was a dose-response relationship between upper and lower limb strength and the risk of depression in the middle-aged and elderly. Logistic regression model showed that after adjusting the confounding factors such as sex, age and marital status, stronger upper and lower limb strength could reduce the risk of depression by 24% and 28%, respectively. Compared with the weakest overall muscle strength group, the strongest muscle strength group had a 48% lower risk of depression (OR=0.52,95%CI: 0.41-0.67).

Strong muscle strength can reduce the risk of depression in the middle-aged and elderly.

To investigate the related factors of death in patients with drug-resistant tuberculosis in Henan Province.

The data of tuberculosis patients diagnosed in all 18 prefecture-level cities and 2 directly administered counties in Henan Province from 2011 to 2021 were selected. The patients with complete course of treatment and treatment outcome were selected. The cumulative survival rate was calculated by Kaplan-Meier method, and Cox proportional hazard regression was used to identify the factors affecting the survival time of patients.

Among the 1 078 patients with drug-resistant tuberculosis, a total of 66 patients (6.1%) died, and the cumulative survival rate within 30 months was 90.1%. In total 50% of the patients died within 10 months. After controlling other factors, age (HR=1.053, 95%CI: 1.029-1.087), XDR-TB patients (HR=3.032, 95%CI: 1.584-5.767), smoking (HR=1.879, 95%CI: 1.006-3.509) and BMI (HR=0.294, 95%CI: 0.088-0.978) were the main risk factors for death of tuberculosis patients during treatment.

Among drug-resistant tuberculosis patients in Henan Province, elderly patients, XDR-TB patients, smoking patients and patients with BMI less than 18.5 have a relatively higher risk of death. Additional support should be provided for the treatment of these patients to reduce mortality.

To analyze the relationship between obstructive sleep apnea (OSA) and nocturnal blood pressure, and to evaluate the possible effect of obesity in this association, so as to provide reference for further exploring the mechanism of OSA-related hypertension.

A total of 753 adult patients diagnosed with OSA were randomly selected from August 2021 to December 2022 in the Sleep Medicine Center of the Fourth West China Hospital of Sichuan University because of snoring, apnea, and other reasons. After polysomnography (PSG) was completed, 753 adult patients diagnosed with OSA were selected as research subjects. The general data of patients, PSG related data, nocturnal blood pressure and related indicators were collected. Correlation analysis and structural equation model were used to analyze the effects of OSA and obesity on nocturnal blood pressure.

In patients with OSA, Apnea Hyponea Index (AHI) was positively correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP) (r=0.297 and 0.222, P < 0.001), and BMI (r=0.443, P < 0.001), and BMI was positively correlated with SBP and DBP (r=0.313 and 0.260, P < 0.001). The results of structural equation model suggested that obesity played an intermediary role in the effect of OSA on nocturnal SBP and DBP. The standardized intermediary effect values were 0.063 (95%CI: 0.035-0.090) and 0.059 (95%CI: 0.032-0.087), respectively, and the proportion of intermediary effect was 21.72% and 26.22%, respectively.

OSA can directly affect the blood pressure of patients. At the same time, obesity plays an intermediary role in the effect of OSA on SBP and DBP.

To investigate the drug resistance and molecular epidemiological characteristics of clinically isolated Staphylococcus aureus in Huai’an city, so as to provide references for the diagnosis, treatment, prevention and control of infection.

Staphylococcus aureus isolated from clinical samples were collected and methicillin-resistant Staphylococcus aureus（MRSA）was detected by cefoxitin or oxacillin resistance phenotype or mecA gene. The drug sensitivity test was carried out by microbroth dilution method. Based on the whole genome sequencing, the strains were analyzed by single nucleotide polymorphism and multi-locus sequence typing. The virulence and drug resistance genes of the strains were identified by online database.

A total of 83 strains of Staphylococcus aureus were isolated from 7 types of clinical specimens, and MRSA accounted for 59.04%. The isolated strains had the highest resistance to penicillin (97.59%) and were sensitive to Nez Olamide, tigecyclines, vancomycin, teicoplanin, and nitrofurantoin, and multiple drug-resistant strains accounted for 57.83%. There were 20 ST types in 83 strains of Staphylococcus aureus, and ST398 (21.69%) was the main type. There were 187 292 SNP loci in 83 genomes. These strains carried 38 kinds of drug resistance genes, among which tet (38), blaZ, arlR, arlS, mgrA, norA, mepA, ErmC,LmrS, and mepR had higher carrying rates. These strains carried 8 enterotoxin genes including sea, seb, sec, sed, seh, selk, sell,and selq, among which selk and selq (both 32.53%) had the highest carrying rate, and ST1 strain carried the largest number of kinds of enterotoxin genes. The carrying rates of lukF-PV and lukS-PV genes encoded by PVL were 49.40% and 6.02%, respectively. The carrying rate of tsst-1 gene encoded by toxic shock syndrome toxin TSST-1 was 3.61%.

The drug resistance of Staphylococcus aureus isolated from Huai’an area is strong and the detection rate of MRSA is high. The ST types of strains are rich, and there is a certain correlation between ST types and pathogenicity.

To understand the current situation of nosocomial infection management in primary medical institutions in Guizhou Province, and to provide reference for standardizing the professional development of nosocomial infection management in primary medical institutions.

By using the method of electronic questionnaire survey, the management of nosocomial infection in primary medical institutions in Guizhou Province from April 1 to 30, 2022 was investigated, and 611 valid questionnaires were retrieved.

Among the 611 primary health care institutions, 401 medical institutions set up nosocomial infection committees, 149 medical institutions set up independent nosocomial infection management departments, 321 medical institutions were equipped with full-time staff for nosocomial infection management, and 573 medical institutions were equipped with part-time staff for nosocomial infection management. In total, 321 primary health care institutions were equipped with 334 full-time staff for nosocomial infection management. The average age was (35.19±8.57) years old, the gender was mainly female, the major was nursing, and the degree was bachelor degree or below. The management of nosocomial infection in different types of primary health care institutions was compared and analyzed, and there were differences in age, professional background, educational background, and working years of nosocomial infection department (P < 0.05). The focus of the full-time staff of nosocomial infection management was the issue of salary.

The construction of the organizational structure of nosocomial infection management in private grass-roots medical institutions in Guizhou Province needs to be strengthened, and some full-time staff are engaged in nosocomial infection management for a short time, so they need to strengthen their ability and training.

To investigate the relationship between hearing loss and the risk of muscular dystrophy in the middle-aged and elderly, so as to provide scientific basis for the prevention and intervention of myogenic in this population.

In this study, people aged 45 and above in the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015 were selected as research subjects. Self-reported hearing loss was used to evaluate hearing loss. Based on the consensus of Asian muscular dystrophy working group in 2019, muscular dystrophy was determined. Cox proportional hazard model was used to investigate the relationship between hearing loss and the risk of myasthenia.

Among 11 528 middle-aged and elderly people, the incidence of baseline hearing loss was 12.8%. During the 4-year follow-up, there were 558 new cases of muscular dystrophy, with an incidence of 6.4%. The results of the Cox proportional hazard model showed that subjects with hearing loss had an increased risk of muscular dystrophy by 31.1% (HR=1.311, 95%CI: 1.059-1.625) compared with those without hearing loss. The results of stratified analysis showed that the relationship between hearing loss and muscular dystrophy was more obvious in women, the elderly, rural household registration, married people, those with education level of junior high school or above, and those with high annual family income.

Hearing loss is related to the increased risk of muscular dystrophy in middle-aged and elderly people in China. Early screening and intervention for hearing loss may help reduce the incidence of future muscular dystrophy.

To analyze the time trend and potential influencing factors of hospitalization of children with mental disorders in Beijing.

The information on hospital admissions of children with mental disorders living in Beijing from 2014 to 2018 was collected. Joinpoint regression model and grey correlation analysis were used to explore the changing trend of hospital admissions and the correlation intensity of the influencing factors.

From 2014 to 2018, the number of hospitalized children with mental disorders showed an upward trend with an average annual change rate of 19.33%. In the subgroup, the number of hospitalized children with mood disorders increased most rapidly (average annual percentage rate change (AAPC) =34.39%), followed by female children (AAPC=31.97%). The results of grey correlation analysis showed that per capita disposable income (correlation degree 0.841) and per capita GDP (correlation degree 0.837) had the strongest correlation with the number of hospitalized children with mental disorders.

The number of hospitalized children with mental disorders increased significantly from 2014 to 2018, and the trend of hospitalization of children with mental disorders with different characteristics and the correlation order of influencing factors were different. We should focus on the strongly related factors of different children with mental disorders and strengthen the mental health education and prevention and control of children in Beijing so as to provide reference for the formulation of relevant policies.

To analyze the coupling and coordination relationship of high-quality development of tertiary public general hospitals in Guangxi, and to explore the path of high-quality development of tertiary public general hospitals, so as to provide a basis for related policy formulation.

The evaluation index system of high-quality development of tertiary public general hospitals in Guangxi was constructed from the four dimensions of medical quality, operational efficiency, sustainable development, and satisfaction evaluation. The coefficient of variation method and rank sum ratio method were used to comprehensively evaluate and classify the high-quality development level of the tertiary public general hospitals in 14 prefectures and cities in Guangxi in 2019, and the coupling coordination degree model was used to calculate the coupling and coordinated development level.

Most of the sample hospitals were in the primary coordination stage, and the proportion of other coupling coordination types from high to low were intermediate coordination (22.73%), reluctant coordination (18.18%), on the verge of disorder (13.64%), and good coordination (4.55%). According to the principle of optimal classification, the tertiary public hospitals in Guangxi were divided into high, medium, and low grades. Most of the hospitals were in the middle level and there was much room for development and progress.

The coupling coordination degree of the tertiary public general hospitals in Guangxi is not high, and there are still some problems, such as uneven distribution of medical resources, large differences in medical quality, and lack of motivation for personnel training. It is necessary to improve the medical service system and improve the core competitiveness.

To understand the effect of establishing health records on the acceptance of health management services in young and middle-aged floating population with hypertension and type 2 diabetes, and to provide references for improving the utilization rate of health management services and realizing the equalization of basic public health services.

Based on the population characteristics, family characteristics, health and public service characteristics of 6 391 young and middle-aged patients with chronic diseases aged 30 to 59 years old in 2017, Probit model and tendency score matching method were used to analyze the effect of health files on the acceptance of health management services in young and middle-aged floating population with hypertension and type 2 diabetes.

The results of Probit model showed that the coefficients of establishing health records for hypertension patients, type 2 diabetes patients, and patients with both diseases were 0.940, 0.905, and 1.333, respectively, and they were all significant at 1% level, indicating that the establishment of health records had a positive effect on the health management services of young and middle-aged floating population with chronic diseases. After correcting the endogenous problems of the model, the result remained robust. Heterogeneity analysis found that there were differences in age, self-rated health, and health education in the establishment of health records.

The establishment of health records has a positive impact on the acceptance of health management services for patients with chronic diseases in young and middle-aged floating population. In the future, we should pay attention to the basic public health service needs of patients with hypertension and type 2 diabetes in young and middle-aged floating population, carry out health education and publicity work for patients with different characteristics, and improve the awareness and utilization rate of basic public health services.