To investigate the effects of blackcurrant on lipid metabolism and intestinal flora in High-Fat Diet mice.

A total of 150 C57BL/6J mice aged 7-8 weeks were selected, with half male and half female. Twelve mice were randomly selected and fed a normal diet as a blank control group. The other mice were fed a high-fat diet for 8 weeks, and the mice with successful obesity modeling were selected and randomly grouped according to gender. The 60 mice were divided into four groups, including high-fat（normal saline）, low-dose（1 250 mg/（kg·d））, medium-dose（2 500 mg/（kg·d））, and high-dose（5 000 mg/（kg·d））, with six mice in each group. The subjects were given continuous gavage for 10 weeks. To evaluate the effect of the intervention and explore the possible mechanism of the intervention. The results were described by (). Differences between groups were tested by ANOVA (α=0.05).

There were significant differences in liver weight, liver coefficient and kidney weight between ND female group and HFD female group and each subject group (P<0.05). The subcutaneous fat mass, perirenal fat mass, perirenal fat mass, and mesenteric fat mass in the ND male group were significantly different from those in the HFD male group and the LOW male group (P<0.05). The subcutaneous fat mass, perirenal fat mass and uterine fat mass of ND female mice were significantly different from those of HFD female group and LOW female group (P<0.05). There were significant differences in TC, TG, HDL-C and LDL-C between the ND male group and the HFD male group and the HIGH male group (P<0.05), and there were significant differences in TG and LDL-C between the ND female group and the HFD female group, the LOW female group and the HIGH female group (P<0.05). There was a significant difference in ALT among the groups (P<0.05). The cells of the liver tissue and adipose tissue in the ND group were intact, and the cells in the HFD group had large fat vacuoles, and the cells in each test group tended to return to normal levels. There was a significant difference in β-diversity among the four groups (P<0.01). The changes in the abundance of Firmicutes, Bacteroidota, and Verrucomicrobiota were also observed (P<0.05).

Blackcurrant can reduce body fat and visceral fat, regulating blood lipid metabolism, protect liver function and regulate intestinal flora.

To investigate the association between dietary oxidative balance score (DOBS) and the risk of sarcopenia in patients with hypertension.

Patients with hypertension aged 20 years and above who participated in four survey cycles of the National Health and Nutrition Examination Survey (NHANES), 2011-2018. Weighted logistic regression and restricted cubic spline were used to analyze the association between DOBS and the risk of sarcopenia in patients with hypertension, and subgroups analysis was performed according to gender and age.

A total of 2 775 patients with hypertension were included, with 349 (12.6%) diagnosed with sarcopenia. After adjusting for multiple covariates, higher DOBS were significantly associated with decreased risk of sarcopenia in patients with hypertension. For each one-point increase in DOBS, the risk of sarcopenia in patients with hypertension was reduced by 11.4% (OR=0.886, 95%CI: 0.842-0.933). As a categorical variable, the OR of DOBS Q3 group was 0.331 (95%CI: 0.116-0.941) and the OR of Q4 group was 0.124 (95%CI: 0.051-0.301) compared with Q1. A restricted cubic spline model indicated a linear negative dose-response association between DOBS and sarcopenia in patients with hypertension (P _non-linear=0.148). Subgroup analysis indicated no significant interaction of gender and age on the association of DOBS and sarcopenia in patients with hypertension (P _interaction > 0.05).

Higher DOBS is significantly associated with a lower risk of sarcopenia in patients with hypertension.

To understand the current status of varicella vaccination among age-eligible children in Chuxiong Prefecture and its influencing factors, in order to provide a reference basis for improving the varicella vaccination rate among age-eligible children throughout the prefecture.

Using multi-stage stratified random sampling, a questionnaire survey was conducted from May to August 2023 among guardians of children aged 1-14 years in three counties and cities of Chuxiong Prefecture, which included basic information, varicella vaccination information, varicella, and knowledge of varicella vaccine. To analyze the influencing factors of varicella vaccination in age-eligible children.

A total of 1 924 questionnaires were collected and 1 921 questionnaires were valid, with a validity rate of 99.84%. 1 918 study participants were finally included in the analysis, with a varicella vaccination rate of 35.82% among children and an overall knowledge rate of varicella and varicella vaccine among guardians of 58.33%. The results of multifactorial analysis showed that living in the city (OR=2.00, 95%CI: 1.62-2.48), per capita monthly family income >10 000 (vs. per capita monthly family income <2 000, OR=2.47, 95%CI: 1.33-4.59), and parental occupation of medical personnel or retired (vs. occupation of housework and inactive work, OR=1.63, and 95%CI: 1.03-2.58), and future willingness to be vaccinated against varicella (OR=5.06, 95%CI: 3.39-7.56) had higher varicella vaccination rates among age-eligible children.

The varicella vaccination rate is low among age-eligible children in Chuxiong Prefecture, and publicity and education on vaccination should be strengthened to increase the willingness of parents of age-eligible children to receive the vaccine, thereby increasing the varicella vaccination rate.

To determine the optimal cut-off point of the General Self-Efficacy Scale (GSES) among middle school students and to establish a precise criterion for evaluating their self-efficacy.

A convenience sampling method was conducted a total of 2 494 junior high school students from grades 7-9 in two junior high schools in Guangzhou were selected for a questionnaire survey. The questionnaire includes demographic characteristics such as students’ gender, grade, and age, general self-efficacy, sleep, family functioning, and smartphone dependence. The latent profile analysis (LPA) was used to classify students’ self-efficacy, and the optimal cut-off point was determined based on the Receiver Operator Characteristic curve (ROC) and the Volume Under the ROC Surface (VUS).

A total of 2 494 middle school students were surveyed in this study. There were 1 285(51.52%) boys and 1 209(48.48%) girls. The self-efficacy of boys was 27(22-31) and that of girls was 24 (20-29), which is statistically significant different (Z=-7.86, P<0.01). LPA identified three categories of self-efficacy: low (862, 34.56%), medium (1 166, 46.75%), and high (466, 18.69%) self-efficacy types. The VUS method determined the optimal cut-off points for the GSES scale to be 22 and 32 points, respectively.The results of the ordinal logistic regression analysis showed that females (OR=1.58, 95%CI: 1.34-1.86), mild family dysfunction (OR=2.86, 95%CI: 2.38-3.44), severe family dysfunction (OR=4.46, 95%CI: 3.51-5.68), mobile phone addiction (OR=1.58, 95%CI :1.1-1.64), and lack of regular exercise (OR=1.75, 95%CI: 1.43-2.15) were positively associated with low self-efficacy, while sleeping time ≥9 hours (OR=0.78, 95%CI: 0.66-0.93) and outdoor activity time ≥1 hour (OR=0.8, 95%CI: 0.65-0.97) were negatively correlated with low self-efficacy among middle school students.

This study provides a clear and scientific assessment criterion for evaluating the self-efficacy level of middle school students through the combination of LPA and VUS methods, offering a powerful tool for more accurate assessment of middle school students’ self-efficacy.

To investigate the association between newly developed non-alcoholic fatty liver disease (NAFLD) in the third trimester of pregnancy and adverse pregnancy outcomes, and to evaluate the necessity of prevention, monitoring, and health education for NAFLD during pregnancy.

This retrospective study included 3 505 singleton primiparous pregnant women without NAFLD in early pregnancy, registered at Beijing Friendship Hospital, Capital Medical University, from March 2020 to December 2022. Logistic regression analysis was used to investigate the association between newly developed NAFLD in the third trimester and adverse pregnancy outcomes, including cesarean section, preterm birth, small-for-gestational-age infants, large-for-gestational-age infants, and postpartum hemorrhage.

After adjusting for factors such as maternal age, gravidity, pre-pregnancy body mass index (BMI) level, gestational weight gain level, relevant medical histories, and educational level, the risk of postpartum hemorrhage was found to be increased in women with newly developed NAFLD in the third trimester (OR=2.136, 95%CI: 1.009-4.080, P=0.031). No statistically significant associations were found with cesarean section, preterm birth, small-for-gestational-age infants, or large-for-gestational-age infants.

A positive association between newly developed NAFLD in the third trimester of pregnancy and postpartum hemorrhage was revealed, highlighting the importance of strengthening surveillance and prevention for NAFLD during pregnancy to reduce the risk of postpartum hemorrhage.

To evaluate the quality of life of the urban older adults with comorbidity from a multi-dimensional perspective, and to verify the influencing factors of the quality of life of the urban older adults with comorbidity by combining the theory of social embeddedness mechanisms.

The questionnaire data of 465 urban older adults with comorbidity were selected as the study sample. One-way ANOVA and independent samples t-test analysis were used to test the differences of different demographic characteristics in the quality of life of the urban older adults with comorbidity, and AMOS 28.0 was used to construct a social embedding structure model of the quality of life of the urban older adults with comorbidity.

The perceived quality of life among urban older adults with comorbidity was rated at a moderate level. In addition, there were significant differences in the quality of life of urban older adults with comorbidity with different genders, ages, marital status, education level, work status, and retirement status. Social support (β=0.10, P<0.001) and social resources (β=0.20, P<0.001) demonstrated positive effects on the quality of life of urban older adults with comorbidity.

Self-reported quality of life are generally higher among urban older adults with comorbidity. Social scenario has a positive effect on social support, and the quality of life of the urban older adults with comorbidity is indirectly improved by strengthening social support. At the same time, social resources not only directly contribute to the quality of life, but also indirectly have a positive impact through social support paths.

To understand the current status of medication adherence in patients with HIV/AIDS who have failed antiretroviral therapy and to analyze the mediating effect of anxiety in the influence of family care on medication adherence.

A total of 600 patients with HIV/AIDS who failed antiretroviral therapy were included as study subjects, and data on patients’ demographic characteristics, behavioral characteristics, anxiety, family caring and medication adherence were collected through telephone interviews, and mediation analyses were used to analyze the mediating effect of anxiety on the relationship between family caring and medication adherence.

In this survey 29.33% of the population had family care disorder, 15.8% were in anxiety and 56.0% had good medication adherence. The mean score of medication adherence was moderate at 7.15±1.38. Anxiety in HIV/AIDS antiretroviral treatment failure patients fully mediated the effect of family care on medication adherence. The mediating effect (0.033) (95%CI: 0.017-0.053) accounted for 47.8% of the total effect (0.069) (95%CI: 0.033-0.105).

The percentage of local HIV/AIDS patients with good adherence to medication in patients who have failed antiretroviral therapy is relatively low. By increasing the level of family care and helping patients to alleviate anxiety, medication adherence can be effectively improved and treatment outcomes can be improved.

To measure the workload of primary public health services in rural township health centers, providing empirical evidence for the healthy development of the rural medical and health system.

A multi-stage stratified random sampling method was employed to select 50 township health centers in Guangxi. Data related to primary public health services and primary medical services were collected, and the workload of primary public health services was analyzed using the equivalent method.

The Pearson correlation coefficient between the total equivalent value of primary public health services and the number of permanent residents served was r=0.782, P<0.05; the coefficient of variation for the total equivalent value of different types of primary public health services was F=51.061, P<0.05; the coefficient of variation for the unit equivalent value of resident health records established in different regions was F=2.836, P<0.05, and for the unit equivalent value of health and family planning supervision and coordination services in different regions was F=6.346, P<0.05.

The total value of primary public health services is strongly positively correlated with the number of permanent residents served. There is a significant difference in the total workload of different types of primary public health services. There are differences in the work efficiency of units providing resident health record establishment and health and family planning supervision and coordination services in different regions.

To investigate the impact of community environment on the trajectory of cognitive function among older adults in China, providing a reference for promoting the construction of age-friendly communities and actively addressing aging.

Based on the data from the China Longitudinal Aging Social Survey from 2014 to 2020, 4 269 elderly individuals were selected. A group-based trajectory model was applied to construct trajectories of cognitive function changes, and a multinomial unordered logistic regression model was used to analyze the relationship between community environment and trajectories of cognitive function.

Three groups of cognitive function trajectories were identified: “Low Decline Group” (21.06%), “Moderate Stable Group” (66.19%), and “High Stable Group” (12.75%). Taking the “low decline group” as the reference group, after controlling for individual basic characteristics and health characteristics, it was found that the higher the community environment score of the elderly, the more their trajectory tended to be in the “High Stable Group” (OR=1.10, 95%CI: 0.93-1.30; OR=1.41, 95%CI: 1.21-1.66), indicating that the community environment has a protective effect on the cognitive decline of the elderly. Stratified analysis showed that compared to females and the elderly living alone, the improvement of the community environment is more beneficial for males and the non-living alone elderly to slow down their cognitive decline.

There is heterogeneity in the cognitive function trajectories of the elderly, and the community environment affects the attribution of cognitive function trajectories. Optimizing the community environment for males and non-lonely elderly can significantly protect their cognitive function.

To explore the impact of standardized clinical pathway management on the cost changes of anterior cruciate ligament injury of the knee and its value in medical practice, with the intention of providing experience for the reform of clinical pathways for disease types and medical insurance payment systems in the context of the DRG payment system.

The study selected a tertiary general hospital in City L as the research object and utilized the interrupted time series analysis method to compare the data before and after the implementation of clinical pathway management.

After the implementation, the average cost per case of this disease type significantly decreased, and the cost structure was optimized. The main cost items such as drug fees, examination fees, and treatment fees all showed a downward trend. The optimization of hospitalization frequency was limited, and the control of consumable costs still needed to be strengthened.

Although clinical pathway management has achieved certain results, it also faces challenges. During the implementation, it is necessary to be vigilant against the decomposition of hospitalizations, strengthen medical insurance supervision and technical monitoring, and optimize hospital management processes. Emphasis should be placed on the value of medical labor and the adjustment of salary systems. Continuous control of consumables is needed to control costs and optimize resource utilization. In the future, the system should be continuously improved to enhance service quality and efficiency, promote the high-quality development of public hospitals, and advance the reform of medical insurance payment systems.