To explore strategies to address the gap and uneven distribution of general practitioner(GP) resources from a provincial perspective, aiming to meet the growing medical needs of the people and advance the reform of the medical and health system.

Based on the provincial GP data from 2013-2022, Kernel density estimation was used to reveal the dynamic evolution of GP resources, while the spatial autocorrelation method was applied to explore their spatial correlation characteristics. Additionally, a spatial econometric model was used to investigate the direct impacts and spillover effects of the factors influencing general practitioner resources.

There is a positive autocorrelation in China’s general practitioner resources. Among the direct effects, urbanization rate and population density have a positive impact on general practitioner resources, while the elderly dependency ratio has a negative impact. In terms of indirect effects, urbanization rate, population density, the proportion of medical and health expenditure in fiscal expenditure, and the number of medical and health institutions all have a negative impact on general practitioner resources.

General practitioner resources in China are not randomly distributed spatially, and the spillover effects of influencing factors in adjacent areas can also impact general practitioner resources. It is recommended to focus on collaboration of medical resources and coordination of medical policies among different regions, promoting cross-regional communication and sharing of general practitioners.

To systematically evaluate the incidence of self-harm behavior and self-harm ideation among HIV/AIDS patients, providing evidence-based support for effectively improving their mental health.

A comprehensive search of relevant studies was conducted in databases including CNKI, CBM, VIP, WanFang Data, PubMed, Embase, Cochrane Library, Web of Science, and PsyclNFO, covering literature up to August 20, 2024. Two researchers independently screened the literature, extracted data, and assessed the quality. Meta-analysis was performed using Stata 17.0 software.

A total of 9 studies were included, with a sample size of 17 414. Meta-analysis of the random effects model showed that the combined incidence of self-harm behaviors and self-harm ideation in HIV/AIDS patients was 12.3% (95% CI: 9.2%-15.4%), the incidence of self-harm behaviors was 12.4% (95% CI: 7.2%-17.6%), and the incidence of self-harm ideation was 13.3%(95% CI: 8.2%-18.5%). Subgroup analyses showed that the prevalence of self-harm behaviors and self-harm ideation was higher among HIV/AIDS patients in Asia and was higher in moderate-quality studies than in high-quality studies. In addition, higher prevalence rates were also observed in studies published before 2015, in people aged 18-24 years, and in studies with <50% males, but these results need to be interpreted with caution in conjunction with the results of the heterogeneity analysis.

The incidence of self-harm behavior and self-harm ideation is relatively high among HIV/AIDS patients, particularly in Asia. Further research is needed to validate differences among various groups and to develop effective intervention strategies.

To analyze the relationship between cardiovascular-metabolic complications andbasic activity of daily living(BADL) and instrumental activities of daily living (IADL) in Chinese middle-aged and elderly individuals, and to explore the factors influencing different types of ADLs in this demographic with cardiovascular-metabolic complications.

The effects of cardiovascular-metabolic co-morbidities on ADLs among middle-aged and elderly individuals were investigated using the χ² test and logistic regression model in a sample of individuals aged 45 and older from the 2020 China Health and Elderly Care Tracking Survey.A randomized forest prediction model was developed to investigate the influencing factors of different types of activities of daily living in middle-aged and elderly people with cardiovascular-metabolic co-morbidities, and to predict the importance of each influencing factor.

Among China’s middle-aged and elderly population, 19.75% had at least one cardiovascular metabolic disease (CMD), and 4.18% had cardiovascular metabolic co-morbidities (CMM). The prevalence of BADL impairment was 15.90%, and that of IADL impairment was 17.32%.After adjusting for confounding factors like age and sex, middle-aged and older adults with cardiovascular metabolic co-morbidities had a higher risk of developing impaired ADLs compared to their counterparts without these co-morbidities (BADL: OR=1.662, 95% CI: 1.246-2.216; IADL: OR=2.186, 95% CI: 1.663-2.874).Age, depression, pain distress, life satisfaction, literacy, and participation in social activities were predictive of impaired BADL and IADL in older adults with multiple cardiovascular-metabolic co-morbidities, with good predictive modeling (BADL: AUC=0.804; IADL: AUC=0.761).

Middle-aged and older adults with multiple cardiovascular-metabolic co-morbidities are more likely to experience impairments in ADLs. Healthcare providers should consider the specific conditions and risk factors of this demographic and develop personalized, multidimensional intervention programs focusing on mental health, pain and chronic disease management, and life satisfaction enhancement to prevent ADL decline in those with cardiovascular-metabolic co-morbidities.

To analyze the influencing factors of preventive service cost in Guizhou Province from 2016 to 2022 by using grey correlation degree method.

Based on the accounting results of “SHA2011” and the data of “Guizhou Statistical Yearbook” and “Guizhou Health Statistical Yearbook”, the factors affecting the cost of preventive services in Guizhou from 2016 to 2022 were analyzed by using grey correlation method.

The highest correlation with the cost of preventive services in Guizhou province was the number of health technicians in epidemic prevention and control and maternal and child health institutions (0.826), followed by the gross enrollment rate of higher education (0.735), the number of health technology beds in epidemic prevention and control and maternal and child health institutions (0.730). The lowest correlation was the proportion of tertiary industry in GDP (0.593).

Health resource input has the strongest correlation with the cost of preventive services. Health fund input and public health services are the main influencing factors of the cost of preventive services in Guizhou Province. At the same time, full attention should be paid to the influence of social factors such as economic development, education level, urbanization level and age structure on the cost of preventive services.

To explore the current situation and influencing factors of medical students’ sleep quality, and to provide targeted intervention measures for improving sleep quality.

A questionnaire survey was conducted among 2884 medical students from September 2021 to January 2022 using a convenience sampling method. Multiple correspondence analysis and multivariate logistic regression analysis were used to explore the influencing factors of medical students’ sleep quality.

The prevalence of poor sleep quality among medical students was 70.32%. The results of multiple correspondence analysis showed that female medical students, sophomores, those with poor self-rated interpersonal relationships and poor health-promoting lifestyles were more likely to have poor sleep quality. The results of multiple stepwise logistic regression analyses showed that four independent variables entered the regression equation, gender (OR_female=1.34,95% CI: 1.13-1.60), grade (OR_sophomore=2.23,95% CI: 1.72-2.88), self-rated interpersonal relationships (OR_poor=1.76,95% CI: 1.47-2.12) and health-promoting lifestyle (OR_poor=2.02, 95% CI: 1.70-2.39).

The prevalence of poor sleep quality among medical students is at a high level. There is a need to focus on sophomores and female students, and to take targeted interventions from the aspects of interpersonal relationship improvement and healthy lifestyle development to improve sleep quality.

To analyze the data of public consultation events and corresponding online public opinion on disease prevention and control in Chengdu from 2017 to 2023, so as to provide reference for understanding the public’s demand for public health information and reducing the occurrence of adverse public opinion in disease prevention and control and response to emergency public health events.

Collect information on public consultation events related to Chengdu Center for Disease Control and Prevention from 2017 to 2023, and use Baidu search tool “Baidu Index” to collect public opinion monitoring data during the same period. Statistical analysis was conducted on the distribution of public consultation events and their correlation with the Baidu Index of corresponding keywords using methods such as statistical description, chi square test, and linear correlation.

From 2017 to 2023, a total of 7 253 public consultation incidents were received, with the highest number in 2022 (4 915); 12345 hotline platform calls are the main source, accounting for 58.78% (4 263 cases); The main types of consultations from 2017 to 2019 were vaccination issues; From 2020 to 2023, the consultation related to COVID-19 will account for 90.41% (5 952/6 583), and the questions related to the prevention and control of COVID-19 (χ²=1 092.147, P<0.001) and COVID-19 nucleic acid detection (χ²=45.083, P<0.001) in 2022 have increased respectively compared to 2020-2021; In 2023, the proportion of non-COVID-19 related vaccination issues and disease prevention and control issues will decrease (χ²=459.109, P<0.001) and increase (χ²=13.999, P<0.001) respectively compared with that before COVID-19; Linear correlation analysis showed that the number of questions related to vaccination between the “vaccination” search index (r=0.864, P=0.027), the number of questions related to COVID-19 prevention and control between the “COVID-19” search index (r=0.794, P=0.033) and information index (r=0.872, P=0.010), the number of questions related to COVID-19 vaccination between the “COVID-19 vaccine” search index (r=0.840, P=0.018) and information index (r=0.835, P=0.019), and the number of questions related to COVID-19 nucleic acid detection between the “nucleic acid detection” information index (r=0.972, P<0.001) were positively correlated respectively.

Using public health professional knowledge to answer questions for the public is a targeted form of health education. In daily work, we should pay more attention to public opinion monitoring, understand public needs through multiple channels, strengthen public opinion guidance and risk prediction, continue to carry out publicity and education, and improve public health literacy; When an emergency public health event occurs, it is necessary to promptly disclose the epidemic situation, strengthen prevention and control propaganda and guidance, inform the public of response methods, and continuously optimize prevention and control measures to provide support for disease prevention and control and response to emergency public health events.

To construct a Propionibacterium acnes (P. acnes)-induced cellular inflammation model and to study the anti-inflammatory effect of a thermal water.

Utilize human immortalized keratinocytes (HaCaT) was used in the experimentation. Co-incubate the cells with thermal spring water and employ the CCK-8 assay to assess cell viability, screening for the optimal intervention time for the thermal spring water. Expose the cells to varying concentrations of P. acnes for different times, measure cell viability, calculate the 50% inhibitory concentration (IC₅₀) of P. acnes, and determine the model induction conditions by testing IL-6 levels. The cells were soaked in thermal spring water for 0.5 hours, followed by co-culturing with P. acnes as the preventive intervention group, or co-culturing with P. acnes first and then soaking the cells in hot spring water for 0.5 hours as the therapeutic intervention group. The levels of cell viability, pro-inflammatory cytokines, and gene expression of inflammation pathways were assessed using the CCK-8 assay, ELISA, and RT-PCR, respectively. Concurrently, control groups with saline solution, tap water, and pure water, along with model and blank controlswere set up.

After treating the cells with thermal spring water and physiological saline for 0.5 hours, cell viabilities were 92.7% and 99.09%, respectively, which led to the selection of 0.5 hours as the intervention time for subsequent experiments.P. acnes at an OD₆₀₀ of 0.25 was co-incubated with the cells for 5 hours to establish the model. In the preventive intervention, the secretion levels of IL-1β and IL-8， as well as the relative expression levels of IL-6, TNF-α, IL-8, and the genes TLR2 and NF-κB in the cells of the thermal spring water group, were all lower than those in the model group (P<0.05), and significantly lower than those in the saline solution group. In the therapeutic intervention, the contents of IL-6, IL-1β, TNF-α, and IL-8, as well as the expression levels of the genes IL-6, IL-1β, TNF-α, TLR2, and NF-κB in the thermal spring water group, were all lower than those in the model group. The contents of IL-6, IL-1β, TNF-α, and the expression levels of the genes IL-6, IL-1β, IL-8, TLR2, and NF-κB were also significantly reduced compared to those in the saline solution group (P<0.05).

This thermal water may exert its anti-inflammatory effect by down-regulating the expression of TLR2 and NF-κB genes in inflammatory signalling pathway and by reducing the secretion of pro-inflammatory cytokines.

To explore the relationship between the dynamics of plant-based diets and mortality in Chinese older adults.

Based on the data from the Chinese Longitudinal Healthy Longevity and Happy Family Study (CLHLS), older adults who participated in the three surveys from 2011-2018 were selected. The HPDI and UPDI scores of the study participants were calculated in 2011 and 2014, respectively, and they were categorized into four groups based on the median of their two scores: low-low, low-high, high-low and high-high groups. Cox proportional risk regression models were used to analyze the relationship between the dynamics of plant-based diets and mortality in the elderly.

A total of 4 382 subjects were enrolled in this study, and 1 689 (38.5%) of them died during the 7-year follow-up period. The results of Cox proportional hazards regression model showed that after adjusting for confounding factors such as gender, age, and education, the risk of death in the high-high HPDI group was reduced by 17% (HR=0.83, 95% CI: 0.72-0.97), while the risk of death in the high-high UPDI group was increased by 29% (HR=1.29, 95% CI: 1.11-1.49).

Older adults who maintain a healthy plant-based diet have a lower risk of death.

To explore the parallel mediating effects of life satisfaction and parent-child relationship satisfaction on the relationship between daily living activity ability and depression in elderly patients with chronic respiratory diseases, providing references for improving their quality of life.

Data from the China Health and Retirement Longitudinal Study (CHARLS) 2020 were used, involving patients aged 60 and older with chronic respiratory diseases. The PROCESS 4.1 macro was employed to analyze the mediating effects between daily living activity ability and depression, and the bias-corrected nonparametric percentile Bootstrap method was used to validate the mediating variables.

Impaired daily living activity ability was negatively correlated with parent-child relationship satisfaction (r=-0.08, P < 0.01) and life satisfaction (r=-0.16, P <0.001), while positively correlated with depression (r=0.35, P < 0.001). The mediating effect analysis indicated that the total effect value of daily living activity ability on depression was 0.231 (95%CI: 0.600-0.944), with a direct effect value of 0.183(95%CI: 0.451-0.773). Life satisfaction and parent-child relationship satisfaction played parallel mediating roles between daily living activity ability and depression, with mediating effect values of 0.040 (95%CI: 0.018-0.062) and 0.009 (95%CI: 0.002-0.017), respectively. The total mediating effect accounted for 20.78% (95%CI: 0.023-0.074) of the overall effect.

There is a relationship between daily living activity ability and depression in elderly patients with chronic respiratory diseases.Life satisfaction and parent-child relationship satisfaction serve as parallel mediators in this relationship. Focusing on improving daily living activity ability and enhancing life satisfaction and parent-child relationship satisfaction may help alleviate depression in older patients with chronic respiratory diseases.

To analyze the epidemiological characteristics of public health emergencies in Yunnan Province’s border areas in recent years, providing a scientific basis for effective prevention and control measures.

Data on public health emergencies reported in 25 border counties (cities) of Yunnan Province from 2012 to 2022 were collected through the “China Disease Prevention and Control Information System-Public Health Emergency Reporting Management System”. Descriptive epidemiological methods were employed to analyze the epidemiological characteristics.

From 2012 to 2022, a total of 452 public health emergencies were reported in Yunnan Province’s border areas, with 31 020 cases and 110 deaths, resulting in an overall incidence rate of 0.94% and a case fatality rate of 0.35%. The primary types of events were infectious disease outbreaks (75.2%) and food poisoning (22.1%). The peak periods for infectious disease outbreaks were June and November, while food poisoning peaked from May to July. The leading causes of events were chickenpox (21.0%), COVID-19 (17.7%), and wild mushroom poisoning (9.5%), with wild mushroom poisoning accounting for the most deaths (53 cases, 48.2%). Schools (47.7%) and communities/villages (27.7%) were the main locations for infectious disease outbreaks. Dehong Prefecture reported 192 events, constituting 42.7% of the total, with 13 644 cases, representing 44.0% of the total cases. Twelve (48.0%) border counties (cities) reported 16 public health emergencies caused by imported infectious diseases, primarily from Myanmar (93.7%) and Laos (6.3%). Main diseases included dengue fever (31.3%), COVID-19 (31.3%), and chikungunya (18.8%), with a peak period for imported infectious disease-related events from July to September.

The reported public health emergencies in Yunnan Province’s border areas are mainly due to infectious disease outbreaks and food poisoning, with peak seasons in summer and winter. Major causes include chickenpox, COVID-19, and dengue fever, while the leading cause of death is wild mushroom poisoning. Schools and communities are critical locations for the prevention and control of infectious disease outbreaks. It is recommended that border areas strengthen monitoring, early warning, and risk assessment for key diseases and vectors, with particular attention to cross-border disease prevention and control in regions adjacent to Myanmar.