To analyze the trends of low back pain (LBP) burden in China from 1990 to 2021 and project future trends through 2036.

Data on prevalence, incidence, and disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease 2021 database. Joinpoint regression analyzed trends from 1990 to 2021, while Bayesian age-period-cohort modeling projected trends from 2022 to 2036.

From 1990 to 2021, while total LBP cases increased in China, age-standardized prevalence, incidence, and DALY rates showed overall declining trends. Females consistently bore higher burden than males. Projections indicate age-standardized incidence rates will increase for males but decrease for females by 2036.

China demonstrated reduced LBP burden indicators during 1990-2021, with persistently higher burden among females. Projections suggest diverging future trends between genders, with rising male incidence but declining female incidence.

To analyze the burden and trends of acute lymphoblastic leukemia (ALL) in China from 1990 to 2021,providing reference for prevention and treatment strategies.

Data on incidence, prevalence, mortality, and disability-adjusted life years (DALY) for ALL in China were extracted from the Global Burden of Disease Study database (GBD 2021). The Join point regression model was utilized to fit the trends over the years, identify significant inflection points, and calculate the average annual percentage of change (AAPC) from 1990 to 2021 to reflect changes in disease burden. The distribution and trends of ALL across different time periods, genders, and age groups in China were analyzed.

In 2021, the age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized death rate (ASDR), and standardized DALY rate for ALL in China were 3.64 per 100 000, 22.02 per 100 000, 1.36 per 100 000, and 74.06 per 100 000, respectively, with a higher burden in males than females. The ASIR and ASPR showed an upward trend, while the ASDR and DALY rates significantly decreased, with the gender disparity in disease burden becoming increasingly pronounced. After 2019, the incidence and prevalence rates in the 2-4 age group declined significantly, with the highest incidence, prevalence, and DALY rates observed in those under 1 year of age by 2021, while the highest mortality rate shifted from infants to the elderly.

The overall burden of ALL in China from 1990 to 2021 shows a downward trend, particularly notable in children, while the burden in adults has increased. There is a need to strengthen preventive measures for ALL among males and children while enhancing effective management of the high mortality rates in the elderly population.

To translate and validate the Chinese version of the Sexual Health Literacy Measurement Tool for Pregnancy Prevention Among Adolescents (SHL-PPA).

Following Brislin’s translation model, the SHL-PPA was forward- and back-translated, then culturally adapted by 15 experts. From June to July 2024, 420 participants completed the online questionnaire, with 30 randomly selected for retesting to examine reliability and validity.

The final Chinese version contained 16 items with item-level content validity indices ranging from 0.87 to 1.00 (scale-level=0.97). The scale demonstrated excellent internal consistency (Cronbach’ α=0.918), test-retest reliability (0.811), and split-half reliability (0.829). Exploratory factor analysis extracted three factors explaining 61.715% of total variance. Confirmatory factor analysis showed good model fit (χ²/v=2.250, RMSEA=0.077, IFI=0.921, TLI=0.906, CFI=0.921, RMR=0.042). Significant positive correlation with contraceptive knowledge (r=0.608, P<0.001) confirmed criterion validity.

The Chinese SHL-PPA demonstrates good reliability and validity for assessing contraceptive health literacy among Chinese adolescents, providing a tool for developing pregnancy prevention interventions.

To explore the relationship between children’s sleep quality problems and negative emotions, providing a reference for precise symptom management.

From March to July 2022, a multi-stage stratified cluster sampling method was used to select 54 488 primary and secondary school students from 16 counties/districts. After propensity score matching, 13 266 children (6 633 pairs) were included to construct and compare negative emotional symptom network models. The Pittsburgh Sleep Quality Index (PSQI) and Depression-Anxiety-Stress Scale (DASS) were used for assessment, with a PSQI total score ≥5 defining the sleep quality problem-positive group.

The detection rate of sleep problems in children was 12.2%. Compared with the negative group, the positive group showed higher detection rates of depression (5.9% vs 41.6%), anxiety (6.3% vs 45.7%), and stress (1.8% vs 23.4%) (P < 0.01), with significant differences in negative emotional symptoms (12.46 vs 11.48, P < 0.01). Social anxiety (1.16 vs 1.36) and restlessness (1.13 vs 1.31) were more severe in the positive group (Cohen’s d > 0.8, P < 0.01). Arrhythmia (1.40) was the core symptom in the positive group.

Children’s sleep quality problems are closely associated with negative emotions, with particular attention needed for social anxiety, restlessness, and arrhythmia symptoms.

To investigate the knowledge and attitudes of tuberculosis (TB) control workers regarding preventive treatment for latent tuberculosis infection (LTBI) in Xinjiang Uygur Autonomous Region, providing evidence for promoting LTBI preventive treatment.

A cross-sectional survey was conducted among TB control workers from 14 prefectures in Xinjiang. Data were entered using EpiData 3.1 and analyzed with SPSS 26.0, with statistical significance set at P<0.05.

Among 235 respondents,92.77% (218/235) knew about LTBI, 63.40% (149/235) understood the probability of LTBI progression, 73.62% (173/235) knew screening methods, 29.79% (70/235) recognized high-risk populations, 65.11% (153/235) knew target groups for preventive treatment, and 60.85% (143/235) understood treatment efficacy. Of those aware of LTBI, 71.56% (156/218) believed preventive treatment was necessary. Significant differences (P<0.05) were found in recommending preventive treatment by gender (χ²=4.565, P=0.033), occupation (χ²=10.839, P=0.004), knowledge of treatment efficacy (χ²=16.490, P<0.001), perceived necessity (χ²=122.919, P<0.001), and training experience (χ²=5.200, P=0.023). Main concerns included uncertain efficacy (39.57%), adverse reactions (32.34%), public knowledge gaps (15.32%), and implementation difficulties (12.77%).

TB control workers demonstrated limited knowledge and moderate acceptance of LTBI preventive treatment. Targeted training and education programs are needed to improve acceptance and implementation of preventive treatment among high-risk populations.

To investigate the status and influencing factors of fear of hypoglycemia (FoH) in elderly patients with type 2 diabetes mellitus (T2DM), providing evidence for improving glycemic management and psychological health.

From March 2022 to January 2023, 302 elderly T2DM patients from three tertiary hospitals in Chengdu were assessed using general information questionnaires, Hypoglycemia Fear Survey-Worry Scale, Social Support Rating Scale, and Connor-Davidson Resilience Scale.

The mean FoH score was 33.009±11.243, indicating high overall fear levels. Random forest model screening (optimal λ=0.77925) identified seven key factors in descending importance: psychological resilience, social support, subjective support, objective support, support utilization, hypoglycemia type, and education level. Multiple linear regression showed psychological resilience (β=-0.315, 95%CI: -0.455 to -0.246), subjective support (β=-0.260, 95%CI: -0.845 to -0.374), objective support (β=-0.176, 95%CI:-0.895 to -0.256), and support utilization (β=-0.145, 95%CI:-1.327 to -0.226) negatively influenced FoH, while hypoglycemia type (β=0.314, 95%CI: 2.227 to 3.873) and frequency (β=0.296,95%CI: 2.632 to 4.719) were positive contributors.

Elderly T2DM patients exhibit high FoH levels influenced by multiple factors. Healthcare providers should enhance psychological resilience and social support, with particular attention to patients experiencing severe or frequent hypoglycemic episodes.

To analyze the effects of nighttime sleep duration on postpartum depressive symptoms of couples in Anhui Province on both partners based on the actor-partner interdependence model.

Depression screening using the Edinburgh Postnatal Depression Scale (EPDS) was performed on couples who brought their babies for child health checkups at 42 days, 3 months, 6 months, and 12 months postpartum to maternal and child healthcare facilities in Huaibei City, Jieshou City, Ma'anshan City, and Huangshan City, Anhui Province, from November 2023-October 2024, using the Edinburgh Postnatal Depression Scale (EPDS).To describe the general condition and detection of depressive symptoms in couples, and to analyze the association between the length of nighttime sleep and postpartum depressive symptoms in couples through the actor-partner interdependence model.

A total of 2 424 couples were included in the analysis, and the overall detection rates of depressive symptoms at the four postpartum time points were 18.7% and 19.7% for husbands and wives, respectively. The detection rates of depressive symptoms at the 4 postpartum time points were 17.0%, 20.4%, 19.7%, and 17.8% for husbands and 19.7%, 19.6%, 21.1%, and 18.3% for wives. Spearman's correlation analysis showed that the wife's nighttime sleep duration was negatively correlated with both her own and her husband's depression scores, and positively correlated with the husband's nighttime sleep duration, and the husband's nighttime sleep duration was negatively correlated with his own and his wife's depression scores.Furthermore, the wife's depression scores were positively correlated with her husband's depression scores. The actor-partner interdependence model showed that both wives' and husbands' nocturnal sleep duration were able to predict their own depressive symptoms(β=-0.890, 95% CI=-1.016--0.763, β=-0.417, 95% CI=-0.550--0.284, all P<0.001), the actor effect was significant; in terms of the partner effect, nighttime sleep duration of both wives and husbands predicts each other’s depressive symptoms(β=-0.200, 95% CI=-0.292--0.108, P<0.001).

Postpartum depression is more prevalent among couples in four sites in Anhui Province, and nighttime sleep duration is negatively associated with postpartum depression, with both couples interacting with each other, suggesting that psychological interventions need to be carried out jointly by both couples.

To develop a liquid-liquid extraction combined with ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (LLE-UHPLC-MS/MS) method for simultaneous determination of nine monoester phthalate metabolites (mPAEs) in urine.

1 ml urine sample was subjected to enzymatic hydrolysis by the addition of ammonium acetate solution and β-glucuronidase at 37 °C on a shaker for 16 h. Subsequently, 20 μl of formic acid was added and thoroughly mixed. Liquid-liquid extraction was performed with 3 ml of ethyl acetate, then the mixture was centrifuged and the supernatant was concentrated under nitrogen flow. The residue was reconstituted with 0.20 ml of acetonitrile-water solution (50∶50, v/v). Chromatographic separation was performed on a BEH C18 column (2.1 mm×100 mm, 1.7 μm) using a mobile phase of 0.10% acetic acid in acetonitrile and 0.10% aqueous acetic acid. Analytes were ionized via electrospray ionization (ESI) in negative ion mode and detected by multiple reaction monitoring (MRM), and quantification was achieved through the internal standard curves.

Good linear relationship was obtained for the analytes within 0.50 to 200 ng/ml, with correlation coefficients greater than 0.999. When 1 ml of urine sample was utilized for analysis, the detection limits and the quantitation limits of the method were 1.5×10^-3 to 0.29 ng/ml and 4.9×10^-3 to 0.98 ng/ml, respectively. The recovery rates of the method ranged from 87.05% to 111.5%, with intra-day relative standard deviations of 0.31% to 3.05%, and inter-day relative standard deviations of 0.59% to 3.46%. The nine monophthalates in 277 urine samples from healthy individuals were determined by the proposed method. Except for mono-benzyl phthalate (MBzP), which had a detection rate of 87.73%, the detection rates of other monophthalates were 100%. Mono-butyl phthalate (MnBP) had the highest median concentration of 194.10 μg/g creatinine, while MBzP had the lowest median concentration of 3.7×10^-2 μg/g creatinine.

The established method for simultaneous determination of 9 monophthalates in urine samples was simple, sensitive, and accurate, which is suitable for the accurate exposure assessment of these substances in urine.

To investigate the correlation between online dating and the occurrence of risky sexual behaviors among transnational migrant populations, and to provide scientific evidence for preventing the spread of human immunodeficiency virus(HIV) among transnational migrant populations.

The snowball sampling method was adopted to collect data on transnational migrant populations residing in China. The initial survey seeds were from Yiwu, Guangzhou, Beijing and Hangzhou. Demographic information and data related to sexual behaviors (including the number of casual sexual partners, dating methods, the frequency of condom use, etc.) were collected through questionnaires. The multivariate logistic regression model was used to analyze the correlation between dating methods and risky sexual behaviors.

A total of 341 people were surveyed, with 199 people using condoms consistently, accounting for 58.36%; 99 people using condoms sometimes, accounting for 29.03%; and 43 people never using condoms, accounting for 12.61%. 112 people had multiple casual partners, accounting for 32.84%; and 229 people had only one casual partner, accounting for 67.16%. 48 people met their casual partners through online dating, accounting for 14.08%; and 293 people met their casual partners through non-online dating, accounting for 85.92%. The multivariate logistic regression analysis showed that compared with those who met their casual partners through online dating, those who met their casual partners through non-online dating had a higher probability of using condoms consistently (OR value of 3.358, 95% CI of 1.184-9.522).

Unprotected sexual behaviors among transnational migrant populations are associated with online dating.