To know the status of childhood disabilities among middle-aged and old people in China and its influence, and to provide basis for prevention and rehabilitation of childhood disability.

The data were from the China Health and Retirement Longitudinal Study. The middle-aged and old people who participated in the baseline survey in 2011 and the newly visited middle-aged and old people who were included in the follow-up in 2013, 2015 and 2018 were selected as the research objects. The disability rate during their childhood was described, and the difference of education level, marriage, daily living ability between disability during childhood and adult were analysed.

Among the middle-aged and old people in China, the childhood disability rate was 20.36‰, and the rates of physical disability, intellectual disability, visual disability, hearing disability and speech disability were 8.47‰, 4.36‰, 3.57‰, 5.58‰, and 2.01‰, respectively. The number of childhood disabilities accounted for 12.2% of the total number of disabled people in the middle-aged and elderly. Among the people with disabilities in the childhood period, the proportion of males was higher than females, accounting for 54.1%. Most of the disabled people in the childhood period are from 0 to 6 years old, accounting for 58.2% of the disabled people from 0 to 17 years old. Compared with those with disabilities during childhood, those with disabilities in adulthood, with physical, intellectual, hearing, and speech disabilities had a higher proportion of impaired ADL in middle and old age. Those with visual, hearing, and speech disabilities in adulthood had a higher proportion of depressive symptoms in middle and old age. The differences were statistically significant by χ² test(P<0.05).

About 2% of the middle-aged and elderly people in China suffer from disability during their childhood. The impact of childhood disability runs through the whole life cycle. It is of great significance to take active prevention and rehabilitation measures for the childhood disabilities.

To explore the situation faced by the strategy of Healthy China in the new era and clarify its connotation, feature and logic.

Citespace was used to conduct the bibliometric analysis of the policy and to explain the theoretical connotation of Healthy China based on the literature review.

In the process of integrating health into the rural revitalization strategy, health poverty reduction was implemented. In the face of the great changes unseen in a century, the construction of Healthy China focused on the conceptual practice of systemic, holistic and synergistic, and enriched its value function, theoretical guidance and practical significance.

The study elaborates the history and experience of the health cause, the situation and requirements of the new era, the connotative features and logical rationale of the construction of a healthy China, and provides a reference for the construction of a theoretical system to comprehensively promote the construction of a healthy China and the development of innovative theories.

To investigating the impact of Financial Burden on Health-Related Quality of Life in elderly patients with Chronic Comorbid Conditions and its mechanisms.

A convenience sample of 493 chronic comorbid patients was extracted from two community health service centers in Yanji City. General information was collected using a questionnaire, and the Patient Experiences with Primary Care (ASPC) scale, Comprehensive Score of Financial Burden (COST), Herth Hope Scale, and SF-36 Health Survey were utilized for the investigation.Univariate analysis, partial correlation analysis, and testing a moderated mediation model was conducted.

(1) Financial Burden significantly predicted HRQoL(β=0.32, 95% CI:0.24-0.40, P<0.001);(2) Hope level partially mediated the relationship between Financial Burden and HRQoL (β=0.12, 95% CI:0.08-0.16, P<0.001), accounting for 37% of the total effect; (3) The direct predictive effect of Financial Burden on health-related quality of life (β=0.07, 95% CI:0.01-0.14，P<0.05) and the mediating role of hope in their relationship(β=0.13，95% CI：0.05-0.21，P<0.01) were both moderated by the core features of comprehensive primary care.

This study reveals the mechanism by which Financial Burden impacts HRQoL in elderly patients with chronic comorbidities. The findings emphasize the importance of enhancing economic support and hope levels for this patient group and highlight the role of comprehensive primary care function in mitigating the adverse effects of Financial Burden on HRQoL. These insights contribute to providing more comprehensive and effective medical services to patients with chronic comorbidities, alleviating the impact of Financial Burden, and enhancing their overall quality of life.

To determine the trend of the incidence of Hepatitis B in Chengdu City during 2010 to 2021, and its ecological determinants.

Linear correlations between Hepatitis B incidence and ecological factors was analyzed using the data collected in Chengdu from 2010 to 2021. Principal component analysis was used to eliminate the independent variables’ multicollinearity, and establishing a multivariate linear regression model to determine the ecological predictors of Hepatitis B incidence.

The incidence of Hepatitis B in Chengdu decreased over the period of 2010-2021, from 50.03 per 100 000 to 24.81 per 100 000. multivariate linear regression showed the Results: The incidence of Hepatitis B decreased with the increases of Per capita disposable income(x₁/x₂) and expenditure on health care for urban/rural residents(x₃/x₄), per capita expenditure of rural residents on education, culture and entertainment(x₅), urbanization rate(x₈), per capita residential gross leasable area(x₉), birth rate(x₁₀), number of health institutions per 10 000 people(x₁₁), number of health technicians per 10 000 people(x₁₂), number of hospital beds per 10 000 people(x₁₃), average annual relative humidity(x₁₄). While it increased with the increase of urban/rural household Engel’s coefficient(x₆/x₇)(y=76.514-0.050x₁-0.184x₂-4.358x₃-6.161x₄-3.652x₅+0.821x₆+0.281x₇- 0.081x₈-0.404x₉-1.036x₁₀-0.360x₁₁-0.005x₁₂-0.075x₁₃-0.607x₁₄).

There is a linear relationship between hepatitis B incidence and social economic development, population, health resources and natural environmental factors, which could provide a basis for the prediction of hepatitis B incidence.

To realize rapid qualitative and quantitative detection of 13 triterpenoids in Wolfiporia cocos from Yunnan by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry.

Triterpenoids in Wolfiporia cocos were extracted by ultrasonic extraction (methanol). The separation was carried on an ACQUITY UPLC © HSS C18 column (2.1 mm×50mm, 1.7μm) with, 10 mmol/L ammonium formate-0.1% formic acid aqueous solution and acetonitrile as mobile phase. The gradient elution flow rate was 0.5ml/min, with the column temperature of 30℃. Negative ion multiple reaction monitoring mode was used for detection. Qualitative and quantitative analysis using secondary mass spectrometry and accurate molecular weight.

13 triterpenoids in Wolfiporia cocos were good with in the linear ranges (r≥0.99). The spiked recoveries were from 80.35% to 116.92%, with relative standard deviations of 1.88% to 9.7%. 13 triterpenoids were detected in Wolfiporia cocos samples, and the total contents were between 79 433-85 900 mg/kg.

The method is simple, accurate, efficient and sensitive, and it is suitable for the qualitative and quantitative detection of 13 triterpenoids in Wolfiporia cocos.

To systematically evaluate the risk of estrogen use and ovarian cancer in postmenopausal women.

PubMed, Cochrane, Embase databases and Chinese databases such as CNKI, VIP, and Wan fang were searched by computer. Studies on the correlation between estrogen replacement therapy and ovarian cancer in postmenopausal women up until January 2023 were collected. The methodological quality of the study was evaluated by Stata software and the effective data were extracted for meta-analysis. We used the odds ratio (OR) and its corresponding 95% confidence interval (CIs) to evaluate the relationship between hormone replacement therapy and ovarian cancer. When there was statistical heterogeneity between studies (P≤0.1 and I²≥ 40%), random effect model was used for meta-analysis; otherwise, fixed effect model was used for analysis.

A total of 14 retrospective studies including 10 cohort studies and 4 case-control studies were identified. Meta-analysis showed that postmenopausal estrogen therapy increased the risk of ovarian cancer in women (OR=1.27, 95%CI: 1.14-1.43). Stratified analysis showed that there was no significant increase in the risk of ovarian cancer in postmenopausal women who took estrogen for less than 5 years (OR=1.04, 95%CI: 0.90-1.20). Postmenopausal women who received estrogen treatment for 5 to 10 years had a significantly increased risk of developing ovarian cancer (OR=1.27, 95%CI: 1.06-1.53). Postmenopausal women who had been treated with estrogen for more than 10 years had a significantly increased risk of ovarian cancer (OR=1.69, 95%CI: 1.42-2.02).

The risk of ovarian cancer in postmenopausal women treated with estrogen replacement therapy is related to the course of estrogen therapy. There is no significant increase in the risk of ovarian cancer within 5 years, but the risk of ovarian cancer is significantly increased when the course of treatment exceeds 5 years.

To analyze the molecular network characteristics of the transmission relationship of newly confirmed human immunodeficiency virus type 1 (HIV-1) infection in Jinan, to provide basis for epidemic trend and prevention.

A total of 168 blood samples newly reported to be infected with HIV-1 in Jinan in 2021 were collected. The pol region gene of HIV-1 was amplified by nested PCR, the evolutionary tree was constructed by neighbor-joining method, and the molecular network was constructed by gene distance < 1.5%. The related factors of the network were analyzed. The mutation sites of drug resistance were analyzed by the online software tool of HIV drug resistance database of Stanford University.

There were 9 subtypes in the sample sequence. The dominant subtypes were two epidemic recombination types circulating recombinant form (CRF), CRF01_AE subtype (41.7%, 70/168), and CRF07_BC subtype (36.3%, 61/168). The other subtypes were B, CRF68_01B,CRF55_01B, CRF65_CPX, CRF67_01B, CRF96_CPX, and C. When the gene distance was 1.50%, a total of 15 molecular clus ters were formed, with a total of 51 sequences, and the network entry rate was 30.4%. Surveillance drug-resistance mutations(SDRM) were monitored in 7 samples, with drug resistance transmission rate of 4.2%, focusing on drug resistance site mutations of nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors.

There are abundant HIV-1 subtypes in Jinan, mainly CRF01_AE and CRF07_BC subtypes. A molecular transmission network should be established for long-term monitoring to take targeted measures to block its spread.

To explore the coordination relationship and spatial pattern of health resource allocation and socioeconomic development in Sichuan Province, to provide references for promoting the high-quality development of health and social economy.

Entropy method, comprehensive evaluation index, and coupling coordination degree model were used to evaluate the level and coupling coordination degree of health resources and socio-economic development. Hot spot analysis was used to explore the characteristics of spatial agglomeration.

From 2017 to 2021, the development level of health resource allocation in different economic regions of Sichuan Province was in the following order: northwest Sichuan Ecological Demonstration Zone (0.59), Panxi Economic Zone (0.35), Chengdu Plain Economic Zone/Southern Sichuan Economic Zone(0.30), and Northeast Sichuan Economic Zone (0.23). The order of social and economic development level was as the follows:Chengdu Plain Economic Zone (0.25), Panxi Economic Zone (0.16), South Sichuan Economic Zone (0.15), Northeast Sichuan Economic Zone (0.10), and Northwest Sichuan Ecological demonstration Zone (0.08). In the past five years, most of the coupling coordination degree of different economic regions showed an increasing trend. Only the average coupling coordination degree of northeast Sichuan economic zone was less than 0.4, which was in a maladjusted recession, while the average coupling coordination degree of the remaining four economic zones was between 0.4 and 0.5, which was in transition harmony and generally subject to the lag of social and economic development. The level of coupling coordination showed a spatial pattern of“high in the west and low in the east”, and the agglomeration characteristics were mainly “high-high” agglomeration area in western Sichuan and “low-low” agglomeration area in northeastern Sichuan.

There are obvious regional differences in the allocation of health resources and the level of socio-economic development in Sichuan Province. The trend of coupling and coordination between the two systems is gradually improving, but the degree of coordination is not high. In addition, the coupling coordination level has significant spatial characteristics, and the local area shows agglomeration effect.

To study the causal relationship between rheumatoid arthritis (RA) and atherosclerosis (AS) by two-sample Mendelian randomized analysis.

The whole genomes of RA and different subtypes of AS were obtained from IEU Open GWAS (https://gwas.mrcieu.ac.uk/) database. Two-sample Mendelian randomized analysis was carried out using the inverse-variance weighted (IVW) method, MR-Egger regression, simple mode, weighted mode, and weighted median (WM),and the results were verified by multiple sensitivity analyses.

In total 86 single nucleotide polymorphisms (SNPs) strongly associated with RA were included as instrumental variables in this study. According to IVW, RA was associated with coronary atherosclerosis (OR=1.034, 95%CI: 1.010-1.058) and peripheral atherosclerosis (OR=1.083, 95%CI: 1.041-1.127, P=0.001). Heterogeneity test, horizontal multiple effect analysis, sensitivity analysis, and MR-PRESSO further clarified the causal relationship by Mendelian randomization analysis.

RA has positive causal correlations with coronary atherosclerosis and peripheral atherosclerosis, but there is no causal correlation between AS and RA by reverse MR analysis. RA increases the risk of coronary atherosclerosis and peripheral arteriosclerosis. It is suggested to actively control RA to reduce the risk of AS.