To apply Social Network Analysis(SNA) to analyze the characteristics of the social support network from 18 to 50 years old HIV/AIDS patients receiving community follow-up management in Luzhou City, and to provide a basis for the development of social support and health intervention work.

A quota sampling method was used, with young and middle-aged HIV/AIDS patients receiving community follow-up management in Luzhou City as the survey subjects. A social support network matrix questionnaire was designed, and a relationship matrix was constructed using Excel 2016. The social support network characteristics were analyzed using UCINET 6.0 software, and a 2-mode social network graph was drawn using Net-Draw.

The social support scores of 165 young and middle-aged HIV/AIDS patients who received community follow-up management in Luzhou City were 24.15±8.10, as follows: hospital(2.45), community(2.36), family(2.16), new media(1.65), traditional media(1.59), friends(1.47), relatives(1.30), social organizations(1.18), colleagues(0.95), and neighbors(0.83); The overall density matrix of the social support network is 1.59, with a core edge final goodness of fit of 0.61, indicating a good fit. Among them, hospitals and communities had the highest centrality and were located in the main core position, while family and new media were in the secondary core position. The rest were situated in the periphery.

The social support level of young and middle-aged HIV/AIDS patients receiving community follow-up management in Luzhou City is relatively low, mainly relying on support from hospitals, community health service centers, family, new media, and social organizations as supplementary sources. In the future, it is recommended to establish a social support network with hospitals and communities as the core, utilizing family members as bridges. Furthermore, expanding the social support network through social organizations and implementing internet-based health interventions can increase the variety and intensity of support, improve the patients’ quality of life, and also serve as a reference for other regions.

To explore the prevalence and gender distinctions of metabolic syndrome in elder adults in urban communities and to provide targeted guidance on early intervention of metabolic syndrome.

The data were collected from the 2019 medical examination data of the elderly population aged 65 years or older in Qingyang District, Chengdu, China. Sociodemographic characteristics, health-related behavioral indicators, health self-assessment reports, and metabolic syndrome indicators were selected for the chi-square test and then multi-categorical logistic regression analysis using StataSE16.0 software.

The prevalence of metabolic syndrome was 35.12% in total, with women (35.81%) having a higher rate compared to men (34.15%), and multifactorial regression analysis showed a higher risk for women, 70-79 years, smoking, and salt addiction. Model 2 and Model 3 regression analyses for men and women showed that partial mental partial physical labor, and maintaining exercise more than once a week were associated with a low risk of developing metabolic syndrome in old age in both male and female populations. Middle school (OR=1.27, 95% CI:1.12-1.44), High school (OR=1.26, 95% CI:1.10-1.45), smoking (OR=1.11, 95% CI:1.01-1.22), and alcohol occasionally (OR=1.15, 95%CI:1.04-1.27) were only associated with a high risk of developing metabolic syndrome in the male elderly population while education level at junior high school and above (OR=0.85, 95% CI:0.77-0.93), and satisfactory health self-assessment reports in older adults (OR=0.78, 95% CI:0.61-0.99) were only associated with a lower risk of the disease for women.

The prevalence of metabolic syndrome in older adults in urban communities is high, and there are significant gender differences. In the following prevention, control, and intervention work, we should strengthen personalized interventions, targeting and monitoring of key populations.

To analyze the influencing factors of condom use frequency and multiple sexual partners(two variables reflecting risky sexual behavior) among HIV-infected women of childbearing age in Xinjiang, and to explore the mediating effect of the "discrimination perception-anxiety-risky sexual behavior" path.

From September 2021 to September 2022, 231 HIV-infected women of childbearing age were selected from designated antiviral treatment institutions in Xinjiang Province by convenient sampling method. A questionnaire survey was conducted among them, and binary logistic regression was used to analyze the factors related to condom use and multiple sexual partners per sexual act. ROC curve and AUC value were used to evaluate the model effect. AMOS software was used to establish the mediating effect model of the discrimination-anxiety-risky behavior path.

Among the 231 participants, 25.41% were infected with multiple sexual partners, 36.4% used condoms every time they had sex, 47.6% were protected, and 52.4% were mild or vulnerable. Unclear HIV infection status of sexual partners(OR=12.515, 95% CI: 3.088-50.724), high perception of discrimination(OR=1.103, 95% CI: 1.052 -1.156) were risk factors for multiple sexual partners, and medication compliance was good(OR=0.338, 95% CI: 0.149-0.763) as a protective factor for multiple sexual partners; HIV positive OR unknown sexual partner(95% CI:0.049-0.499), rural domicile(OR=0.477, 95% CI:0.260-0.877), anxiety(OR=0.973, 95% CI:0.949-0.997) were the relevant factors for condom use; "Discrimination perception" could indirectly affect "risky sexual behavior" through "anxiety", and the indirect effect size of this path was 0.031, accounting for 10.8% of the total effect.

Low frequency of condom use and multiple sexual partners in HIV infected women of childbearing age in Xinjiang Province lead to the occurrence of risky sexual behaviors.

To further investigate the risk factors of Hyperuricemia(HUA) using Mendelian randomization study and its causal relationship, and to lay the theoretical foundation for the prevention and control of hyperuricemia.

In the first, we regarded the HUA-related factors as the exposure and the uric acid as outcomes, and two-sample Mendelian randomization analysis was made based on the data from genome-wide association study concerning European populations. Then, the variable possibly bearing a cause and effect relationship to the outcomes in the Mendelian study was further analyzed by multivariate Mendelian randomization analysis to determine the independent influence of the variables on the outcomes.

Two-sample Mendelian randomization study results showed that the increase in the body mass index, the triglycerides level and the pork consumption and the decrease in the high-density lipoprotein cholesterol could lead to the increase in the uric acid. Multivariate Mendelian randomization study results showed that the causality between the three factors including BMI(b=0.246, P=8.89×10^-9), HDL(b=-0.074, P=0.046) and TG(b=0.145, P=7.32×10^-5) and UA still held, while causality between pork consumption and UA showed no statistical significance(b=-0.074, P=0.096).

Body mass index, high density lipoprotein cholesterol, triglyceride have a causal relationship with uric acid.

To know the status of childhood disabilities among middle-aged and old people in China and its influence, and to provide basis for prevention and rehabilitation of childhood disability.

The data were from the China Health and Retirement Longitudinal Study. The middle-aged and old people who participated in the baseline survey in 2011 and the newly visited middle-aged and old people who were included in the follow-up in 2013, 2015 and 2018 were selected as the research objects. The disability rate during their childhood was described, and the difference of education level, marriage, daily living ability between disability during childhood and adult were analysed.

Among the middle-aged and old people in China, the childhood disability rate was 20.36‰, and the rates of physical disability, intellectual disability, visual disability, hearing disability and speech disability were 8.47‰, 4.36‰, 3.57‰, 5.58‰, and 2.01‰, respectively. The number of childhood disabilities accounted for 12.2% of the total number of disabled people in the middle-aged and elderly. Among the people with disabilities in the childhood period, the proportion of males was higher than females, accounting for 54.1%. Most of the disabled people in the childhood period are from 0 to 6 years old, accounting for 58.2% of the disabled people from 0 to 17 years old. Compared with those with disabilities during childhood, those with disabilities in adulthood, with physical, intellectual, hearing, and speech disabilities had a higher proportion of impaired ADL in middle and old age. Those with visual, hearing, and speech disabilities in adulthood had a higher proportion of depressive symptoms in middle and old age. The differences were statistically significant by χ² test(P<0.05).

About 2% of the middle-aged and elderly people in China suffer from disability during their childhood. The impact of childhood disability runs through the whole life cycle. It is of great significance to take active prevention and rehabilitation measures for the childhood disabilities.

To determine the trend of the incidence of Hepatitis B in Chengdu City during 2010 to 2021, and its ecological determinants.

Linear correlations between Hepatitis B incidence and ecological factors was analyzed using the data collected in Chengdu from 2010 to 2021. Principal component analysis was used to eliminate the independent variables’ multicollinearity, and establishing a multivariate linear regression model to determine the ecological predictors of Hepatitis B incidence.

The incidence of Hepatitis B in Chengdu decreased over the period of 2010-2021, from 50.03 per 100 000 to 24.81 per 100 000. multivariate linear regression showed the Results: The incidence of Hepatitis B decreased with the increases of Per capita disposable income(x₁/x₂) and expenditure on health care for urban/rural residents(x₃/x₄), per capita expenditure of rural residents on education, culture and entertainment(x₅), urbanization rate(x₈), per capita residential gross leasable area(x₉), birth rate(x₁₀), number of health institutions per 10 000 people(x₁₁), number of health technicians per 10 000 people(x₁₂), number of hospital beds per 10 000 people(x₁₃), average annual relative humidity(x₁₄). While it increased with the increase of urban/rural household Engel’s coefficient(x₆/x₇)(y=76.514-0.050x₁-0.184x₂-4.358x₃-6.161x₄-3.652x₅+0.821x₆+0.281x₇- 0.081x₈-0.404x₉-1.036x₁₀-0.360x₁₁-0.005x₁₂-0.075x₁₃-0.607x₁₄).

There is a linear relationship between hepatitis B incidence and social economic development, population, health resources and natural environmental factors, which could provide a basis for the prediction of hepatitis B incidence.

To explore the relationship among self-perceived burden, family resilience and quality of life in patients with ovarian cancer, and to analyze the potential role of family resilience between self-perceived burden and quality of life.

Ovarian cancer patients hospitalized in the oncology departments of two tertiary hospitals in Sichuan Province from May 2022 to January 2023 were selected as the research subjects, and the general information questionnaire, family resilience assessment scale (FRAS), self-perceived burden scale of cancer patients (SPBS-CP), and ovarian cancer quality of life scale (FACT-O) were used to conduct questionnaire surveys. SPSS 22.0 was used for descriptive analysis, correlation analysis and multiple linear regression analysis. PROCESS 3.4 was used to analyze the mediating effect of family resilience between self-perceived burden and quality of life, and the Bootstrap method was used to test the mediating effect.

The family resilience score of ovarian cancer patients was (140.61±15.82), self-perceived burden was (59.46±19.95), and quality of life was (91.52±32.01). There was a positive correlation between family resilience and quality of life in patients with ovarian cancer (r=0.464, P<0.01), and the self-perceived burden was negatively correlated with family resilience and quality of life (r=-0.385, -0.439, P<0.01). Family resilience had a partial mediating effect between ovarian cancer patients’ self-perceived burden and quality of life, and the mediating effect accounted for 30.35% of the total effect.

The self-perceived burden of ovarian cancer patients is at a moderate level, family resilience is at a lower middle level, and the quality of life needs to be improved. It is recommended that healthcare professionals improve the quality of life by enhancing family resilience and reducing the burden of self-perception through health education methods such as enhancing family support, establishing coping beliefs, and promoting family communication.

To provide scientific basis for formulating strategies to improve the health management of medical personnel, we analyze the resilience level, coping styles, and influencing factors of 2 100 medical personnel under sudden public health emergencies.

Using the convenience sampling method, 22 medical institutions were selected from Pudong New Area, Shanghai, and a self-designed electronic survey questionnaire was distributed based on the professional characteristics of medical personnel, the resilience scale of medical personnel, and the coping style scale.

The total score of medical staffs’ resilience was 71.246±11.442. The total score of medical staffs’ coping style was 58.614±11.493. The results of multiple linear regression analysis showed that the main factors affecting the resilience level of medical staff were hospital type (social health service center t=1.966, P=0.049), employment form (contract system t=4.031, P<0.001), professional title (intermediate professional title t=2.749, P=0.006), marital status (married t=3.471, P=0.001), monthly income (5 000-10 000 t=2153, P=0.031, >10 000 t=2.475, P=0.013), received psychological training (t=6.295, P<0.001). The main factors affecting the coping style level of medical personnel were hospital type (social health service center t=2.612, P=0.009), time of medical activity (11-20 years social health service center t=2.484, P=0.013, >20 years t=2.594, P=0.010), employment form (contract system t=3.716, P<0.001), professional title (intermediate professional title t=2.268, P=0.023), psychological training received (t=6.338, P<0.001) and occupational type (management t=2.218, P=0.027).

The level of resilience and coping style of medical personnel need to be improved. Meanwhile, hospital type, employment form, professional title, marital status and psychological training are the influencing factors of resilience and coping style of medical personnel.

To describe the incidence of adverse birth outcomes in AIDS-infected parturients in Anhui province, and to analyze the effects of antiretroviral treatment, complications during pregnancy, and other socio-demographic factors on adverse birth outcomes.

Information of all HIV-infected mothers and their newborns in Anhui province from 2011 to 2023 was collected from the National Direct Reporting Information System for the Prevention of mother-to-child transmission of AIDS, Syphilis, and Hepatitis B. The risk factors of adverse birth outcomes among HIV-infected mothers were analyzed by Chi-square test and multiple logistic regression analysis.

In Anhui Province, the incidence of at least one adverse birth outcome, preterm birth, low birth weight, stillbirth/neonatal death, and birth defect was 13.9%, 9.0%, 8.2%, 2.6%, and 0.3%, respectively. The risk of total adverse birth outcomes was higher in AIDS-infected women with higher education (OR=2.770, 95% CI: 1.043-7.354), farmers (OR=2.877, 95% CI: 1.454-5.692), and moderate to severe anemia (OR=4.053, 95% CI: 1.411-11.643). Higher education level (OR=3.815, 95% CI: 1.145-12.705), occupation as a farmer (OR=2.763, 95% CI: 1.228-6.218), pregnancy combined with diabetes (OR=2.546, 95% CI: 1.025-6.325) promoted premature birth; The risk of low birth weight was higher in farmers (OR=2.626, 95% CI: 1.108-6.224), taking anti-HIV drugs (OR=12.949, 95% CI: 1.209-138.725), moderate to severe anemia (OR=4.281, 95% CI: 1.288-14.224) and pregnancy-induced hypertension (OR=4.880, 95% CI: 1.207-19.735). First marriage/divorce/widowhood (OR=0.264, 95% CI: 0.108-0.646) was associated with a lower risk of low birth weight than unmarried/cohabiting individuals. The effect of syphilis in pregnancy on stillbirth/neonatal death was statistically significant (OR=32.795, 95% CI: 1.178-913.003).

Further interventions are needed to improve pregnancy outcomes for women living with HIV.