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To further investigate the risk factors of Hyperuricemia(HUA) using Mendelian randomization study and its causal relationship, and to lay the theoretical foundation for the prevention and control of hyperuricemia.
In the first, we regarded the HUA-related factors as the exposure and the uric acid as outcomes, and two-sample Mendelian randomization analysis was made based on the data from genome-wide association study concerning European populations. Then, the variable possibly bearing a cause and effect relationship to the outcomes in the Mendelian study was further analyzed by multivariate Mendelian randomization analysis to determine the independent influence of the variables on the outcomes.
Two-sample Mendelian randomization study results showed that the increase in the body mass index, the triglycerides level and the pork consumption and the decrease in the high-density lipoprotein cholesterol could lead to the increase in the uric acid. Multivariate Mendelian randomization study results showed that the causality between the three factors including BMI(b=0.246, P=8.89×10-9), HDL(b=-0.074, P=0.046) and TG(b=0.145, P=7.32×10-5) and UA still held, while causality between pork consumption and UA showed no statistical significance(b=-0.074, P=0.096).
Body mass index, high density lipoprotein cholesterol, triglyceride have a causal relationship with uric acid.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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