Chen−Hsiang Huang (1910–1987), a renowned medical scientist and virologist, was one of the principal founders of modern virology in China and a member of the Chinese Academy of Sciences. In his early career, Professor Huang pioneered the technique of in vitro tissue culture for viruses internationally, laying the methodological foundation for the global leap in virology from qualitative to quantitative research. After returning to China, he devoted his life to fundamental and applied research in virology. His globally acclaimed achievements included establishing the etiology and epidemiology of epidemic Japanese encephalitis, developing and promoting live attenuated measles vaccines, and pioneering explorations in viral immunology and tumor biotherapy during his later years. As an outstanding scientist and educator, Chen−Hsiang Huang not only built a scientific defense for safeguarding the health and lives of the nation through his outstanding research achievements but also mentored a large number of key medical professionals. More importantly, with his rigorous, pragmatic, and pioneering scholarly attitude, as well as his noble character of unwavering dedication to the country and willingness to contribute, he vividly embodied the spirit of Chinese scientists and erected an immortal monument in the field of Chinese virology.

Continuous−variable quantum key distribution (CV−QKD) technology has emerged as a pivotal direction in quantum secure communication due to its inherent compatibility with classical optical communication systems and high key rates within metropolitan areas. However, the secret key rates of existing CV−QKD systems remain insufficient to meet the practical requirements of one−time pad encryption within metropolitan areas. This work innovatively integrates orthogonal frequency−division multiplexing (OFDM) technology into CV−QKD systems. We experimentally demonstrated, for the first time, a multi−carrier CV−QKD system operating at a 10 GHz repetition rate. Moreover, this experimental system respectively achieves secret key rates of 1819.32, 1078.48, 374.19, 112.96, and 34.63 Mbps over transmission distances of 5, 10, 25, 50, and 75 km by developing a high−precision dual−stage phase noise compensation algorithm, establishing an excess noise theoretical model, and designing a high−throughput data post−processing scheme. Notably, our work realizes the first instance of Gbps−level secret key rates within 10 km and 100 Mbps−level secret key rates within 50 km for metropolitan−area CV−QKD. Compared to traditional single−carrier CV−QKD system with 10 GHz repetition rate under identical experimental conditions, the multi−carrier key rate gains at different transmission distances can respectively reach 1.09@5 km, 1.10@10 km, 1.13@25 km, 1.54@50 km, and 5.55@75 km. These results confirm that the multi−carrier CV−QKD system scheme can significantly enhance quantum key distribution performance, providing an effective solution for future broadband and long−distance quantum secure communication.

Against the backdrop of rapidly growing global data volumes and the escalating demand for high−performance computing, storage technologies have continuously evolved as a critical component of information infrastructure. This study systematically reviews the development trajectories and key breakthroughs of mature storage technologies, including magnetic storage, semiconductor storage, and optical storage, and provides an in−depth analysis of the potential, development paths, and challenges associated with emerging storage technologies such as phase−change memory, resistive RAM, ferroelectric RAM, magnetic RAM, and DNA storage. The study further summarizes the current challenges faced by China's storage industry, including high investment risks, intense market competition, dependence on externally supplied critical materials and equipment, and the "performance–cost–ecosystem" constraints that limit the advancement of new storage technologies. Finally, it proposes development strategies such as enhancing strategic focus, cultivating localized supply chains for materials and equipment, and strengthening core technology research, aiming to provide decision−making references for promoting technological innovation and strategic planning in China's storage industry.

Gene editing refers to the process of specifically modifying organism's genome using specific technical approaches to regulate its genetic information and phenotypic characteristics. Among them, large−fragment gene integration technology enables the accurate insertion or replacement of large exogenous DNA fragments in the organismal genome, which provides core technical support for the development of innovative therapeutic strategies against severe diseases. Starting from the historical origin of this technology, this paper systematically sorts out its developmental trajectory and analyzes the current technical bottlenecks of large−fragment gene integration technology, including exogenous DNA dependence, delivery challenges and prominent immune risks. Given that the novel large−fragment integration techniques based on R2 retrotransposons are expected to become a key solution to break through these limitations, the study further introduces the structural characteristics and retrotransposition mechanisms of R2 retrotransposons, and reviews the research advances in its structural analysis and engineering modification, and summarizes the technical breakthroughs and application prospects of R2 retrotransposon−mediated large−fragment integration tools, which provides theoretical insights and practical references for the application of R2 retrotransposon tools in gene therapy.

Immunotherapies represented by immune checkpoint inhibitors and CAR−T cell therapy have fundamentally transformed the cancer treatment landscape, yet they have repeatedly failed against the most lethal brain tumor, glioblastoma (GBM). Why does this "immunological storm" that has swept through oncology suddenly "extinguish" within the brain This review addresses a core scientific question: Are our current immunotherapy strategies trapped in a "whack−a−mole" predicament when confronting GBM's fortress−like immunosuppressive tumor microenvironment (TME), lacking a comprehensive battle blueprint Through critical examination of the root causes underlying current therapeutic failures, we identify fundamental limitations in drug delivery, target selection, and microenvironment remodeling across three critical dimensions. We propose that future breakthroughs must pivot from "single−target approaches" toward "multi−step, sequential TME holistic remodeling." This requires developing more intelligent delivery systems to "breach the fortress walls," implementing metabolic interventions and targeted suppressive cell elimination to "purify the battlefield," and ultimately "create winning opportunities" for immune effector cells. This review also explores how novel preclinical models and dynamic biomarkers can guide the implementation of this complex strategy, aiming to provide new insights and inspiration for igniting this "immunological desert" of GBM.