To investigate the association between helicobacter pylori infection and serum homocysteine(Hcy) levels as well as brachial-ankle pulse wave velocity(baPWV),and to assess whether helicobacter pylori infection is an independent risk factor for hyperhomocysteinemia and arterial stiffness.

A total of 6 207 adults who underwent physical examinations at our hospital from January 2022 to December 2023 were included.The subjects were divided into the helicobacter pylori positive group and the helicobacter pylori negative group based on the results of the ¹³C urea breath test.Linear regression analysis was used to evaluate the linear association between helicobacter pylori infection and Hcy as well as baPWV.Further, multivariate logistic regression was employed to construct models for high Hcy(≥15 μmol/L) and high baPWV(≥1 800 cm/s),and sensitivity analysis was conducted.

There was no significant linear correlation between helicobacter pylori infection and Hcy or baPWV.High Hcy increased the risk of helicobacter pylori positive individuals(P<0.001),and the risk of having high baPWV was significantly increased(P<0.001).The results of the sensitivity analysis were consistent.

There is no significant linear correlation between helicobacter pylori infection and Hcy or baPWV.However,helicobacter pylori infection significantly increases the risk of high Hcy levels and arterial stiffness.Helicobacter pylori infection may affect vascular elasticity through inflammatory responses,nutrient absorption disorders, or metabolic pathways.

To analyze the latent profiles of artificial intelligence anxiety among undergraduate nursing students,and to explore the influencing factors of artificial intelligence anxiety among different profiles of nursing students.

Using the convenience sampling method,from April to May 2025,a total of 720 undergraduate nursing students from three medical colleges in Hubei province were selected as the research subjects.The general information questionnaire,Artificial Intelligence Anxiety Scale(AIAS) and Medical Artificial Intelligence Readiness Scale(MAIRS) were used for the investigation.

The score of artificial intelligence anxiety among undergraduate nursing students was 86.00±20.95.They could be divided into three latent profiles:low anxiety-rational alertness type (10.4%), medium anxiety-risk sensitivity type(65.3%),and high anxiety-generalized fear type(24.3%).Logistic regression analysis results showed that grade,the willingness to try using artificial intelligence tools in clinical practice,and medical artificial intelligence readiness were the influencing factors of artificial intelligence anxiety among undergraduate nursing students(all P<0.05).

The artificial intelligence anxiety among undergraduate nursing students is at a moderately high level.There is heterogeneity.Nursing educators need to develop precise intervention plans for undergraduate nursing students based on the influencing factors,so as to help them better adapt to the nursing education and career development requirements in the era of intelligence.

To develop the exercise program for maintenance hemodialysis patients during the intermittent period of dialysis based on "zero-time exercise",and to verify its application effect.

The plan was constructed through the summary of best evidence, Delphi expert consultation, and pre-test.Using the convenience sampling method,a total of 90 maintenance hemodialysis patients from a tertiary grade A general hospital in Bengbu city from June 1st to September 10th,2025 were selected as the research subjects.According to the dialysis treatment schedule,the patients were divided into the observation group and the control group,with 45 cases in each.The control group received routine exercise guidance and nursing, while the observation group implemented the inter-dialysis exercise plan based on "zero-time exercise" on the basis of the routine.After 12 weeks of intervention,the objective indicators of physical function,exercise self-efficacy,dialysis symptom burden,blood biochemical indicators,and quality of life between two groups of patients were compared.

The exercise program for maintenance hemodialysis patients during the intermittent period of dialysis based on the "zero-time exercise" included 5 primary indicators,20 secondary indicators,and 54 tertiary indicators.A total of 88 patients completed the intervention,with 44 in the observation group and 44 in the control group.After 12 weeks of intervention,the 30-second sit-to-stand test,2.44 meters circuit walking test,exercise self-efficacy,dialysis symptom burden,and quality of life in the observation group were all better than those in the control group(all P<0.05).

The implementation of the exercise program for maintenance hemodialysis patients during the intermittent period of dialysis based on "zero-time exercise" could improve the objective indicators of physical function of maintenance hemodialysis patients,enhance their exercise self-efficacy,improve the symptom burden of dialysis patients and their quality of life.

To explore the risk factors for patients complicated with perianal infection after allogeneic hematopoietic stem cell transplantation,and to construct and verify the risk prediction model.

A total of 259 patients who underwent allogeneic hematopoietic stem cell transplantation at a tertiary grade A hospital in Chongqing from January 2019 to December 2023 were selected as the modeling group.Relevant risk factors were screened through univariate and multivariate analyses,and a risk prediction model was constructed using R language.A total of 75 patients who underwent allogeneic hematopoietic stem cell transplantation in hospital from January 2024 to March 2025 were selected as the validation group.The model was evaluated and validated using the receiver operating characteristic curve area(AUC),Hosmer-Lemeshow goodness-of-fit test,decision curve analysis,and validation of the prediction model adopted.

The incidence of perianal infection in the modeling group was 18.53%,while that in the validation group was 24.00%.The risk factors of perianal infection after allogeneic hematopoietic stem cell transplantation included the history of perianal diseases,diarrhea,duration of neutropenia,and preoperative prognostic nutritional index.A predictive model for perianal infection after allogeneic hematopoietic stem cell transplantation was constructed based on these risk factors.The AUC value of the modeling group was 0.773,with a sensitivity of 0.604,a specificity of 0.853,and a maximum Youden index of 0.457.The AUC value of the validation group was 0.726,with a sensitivity of 0.745,a specificity of 0.897,and a maximum Youden index of 0.442.The decision curve analysis indicated that this model had good clinical benefits within a wide range of risk threshold probabilities.

The predictive model for patients complicated with perianal infection after allogeneic hematopoietic stem cell transplantation has excellent predictive performance.It could provide a scientific basis for the early assessment of perianal infection after allogeneic hematopoietic stem cell transplantation.

To analyze the risk factors for depression in patients with hepatitis B-related cirrhosis(HBC),to establish a decision tree prediction model,and to formulate nursing interventions to reduce the risk of depression in HBC patients.

A total of 200 HBC patients admitted to our hospital from January 2023 to January 2025 were selected as study subjects.Logistic regression analysis was used to identify risk factors influencing the occurrence of depression in HBC patients.A decision tree model for depression occurrence was constructed using the Chi-squared automatic interaction detection(CHAID) algorithm.The predictive performance of the decision tree model was evaluated by plotting the receiver operating characteristic(ROC) curve and calculating the area under the curve(AUC).

According to the Hamilton Depression Scale(HAMD) scores,all patients were divided into the depression disorder group with 58 cases and the non-depression disorder group with 142 cases.Logistic regression analysis showed that the education level,family support,psychological resilience,disease duration,and Child-Pugh classification were all risk factors for depression in HBC patients(P<0.05).The decision tree model identified 5 explanatory variables,namely Child-Pugh classification,psychological resilience,family care level,disease duration,and educational attainment.Among them,the Child-Pugh classification was the most significant influencing factor for the occurrence of depressive disorders in HBC patients.The AUC of the decision tree model was 0.930.After ten-fold cross-validation, the average AUC of the model was 0.914,which showed a relatively small difference from the original model's AUC.There was no significant overfitting in the model.The generalization ability was good.The Hosmer-Lemeshow test results showed that there was no statistically significant difference between the predicted risk of depression disorder by the model and the actual disease status of the patients.The calibration was good.Using HAMD ≥17 as the diagnostic threshold for depression,the model showed a sensitivity of 87.93%,specificity of 91.55%,and Youden's index of 0.795.

Education level,family support,psychological resilience,disease duration,and Child-Pugh classification are important risk factors for depression in HBC patients.The decision tree model based on these factors demonstrates high predictive value.Clinical practice should develop targeted nursing interventions addressing the above risk factors to reduce the incidence of depression in HBC patients.

To explore the potential classification characteristics and influencing factors of creativity anxiety among master's candidates in nursing.

From June to August 2025,a total of 381 master's candidates in nursing from 7 universities in Henan and Guangdong provinces were selected as the survey subjects.The general information questionnaire,Creativity Anxiety Scale(CAS),Creative Self-efficacy Scale(CSS),and Nurse Professional Identity Assessment Scale.Based on the latent profile analysis,the potential classification of creativity anxiety among master's candidates in nursing was initially explored.The influencing factors of the latent profile analysis were analyzed using unordered multinomial Logistic regression.

The score of the CAS for master's candidates in nursing was 36.31±10.53.The creativity anxiety of master's candidates in nursing could be classified into four potential profiles:the low anxiety balance group,the rule-dependent anxiety group,the value-driven anxiety group,and the achievement-driven anxiety group.Regression analysis showed that the institution level,grade,group meeting frequency,degree type,existing number of papers,degree of recognition of the value of scientific research achievements,creative self-efficacy,and nurse professional identity were the influencing factors of the creativity anxiety of master's candidates in nursing.

There is group heterogeneity in the creative anxiety of master's candidates in nursing.Institutions and supervisors could conduct individualized interventions based on the different influencing factors of the potential profiles,to reduce the level of creative anxiety among master's candidates in nursing.

To explore the latent class characteristics of fear of movement in patients after open-heart surgery,and to analyze its influencing factors.

Using a convenience sampling method, a total of 305 hospitalized patients after open-heart surgery were selected from the cardiac surgery departments of seven tertiary grade-A hospitals from March to May 2025. The patients were surveyed using the General Information Questionnaire, the Tampa Scale for Kinesiophobia for Heart Patients (TSK-SV Heart), the Brief Illness Perception Questionnaire(BIPQ), the Hospital Anxiety and Depression Scale(HADS), the Cardiac Exercise Self-Efficacy Instrument (CESEI), and the Perceived Social Support Scale(PSSS).Latent profile analysis(LPA) was employed to identify the class characteristics of fear of movement in patients after open-heart surgery.

Three latent profiles of fear of movement were identified among patients after open-heart surgery: subclinical fear of movement-unstable group, mild fear of movement-stable group, and moderate fear of movement group. Logistic regression analysis showed that patients' anxiety,depression,illness perception, cardiac rehabilitation exercise self-efficacy, average monthly family income, and exercise habits were influencing factors for their latent profiles of fear of movement(all P<0.05).

Fear of movement in patients after open-heart surgery shows population heterogeneity. Healthcare providers should develop precise intervention strategies based on the influencing factors of different profile groups to reduce patients' level of fear of movement.

To develop the oral frailty assessment scale for elderly stroke patients,and to test its reliability and validity.

Guided by the Adulyanon's oral health consequences model,combined with literature review and expert consultation,the initial draft of the scale was established.A total of 336 elderly stroke patients admitted to the rehabilitation department of a tertiary grade A hospital in Jiangxi province from April to July 2025 were selected for the investigation.The reliability and validity of the scale were tested.

A total of 12 experts were selected for two rounds of expert consultation.The questionnaire recovery rates for the two rounds were 100% and 92% respectively.The expert authority coefficients were 0.850 and 0.807 respectively.The Kendall's W coefficients were 0.326 and 0.412 respectively(all P<0.01).The oral frailty assessment scale for elderly stroke patients included 3 dimensions and 25 items.Exploratory factor analysis extracted 3 common factors,with a cumulative variance contribution rate of 72.397%.Confirmatory factor analysis confirmed that the model had good fit.The scale content validity index(S-CVI) was 0.950,and the item content validity index(I-CVI) ranged from 0.830 to 1.000.The Cronbach's α coefficient of the total scale was 0.928, and the split-half reliability was 0.952.

The oral frailty assessment scale for elderly stroke patients has good reliability and validity.It could be used as an assessment tool for specific symptoms of oral frailty in elderly stroke patients.

To investigate the preference for central vascular access device among breast cancer patients undergoing chemotherapy,and to provide a basis for selecting central vascular access devices for breast cancer patients.

Using the convenient sampling method,a total of 267 patients who received neoadjuvant chemotherapy in the breast surgery department of Nanjing Drum Tower Hospital from January 2023 to March 2024 were selected as the research subjects.A questionnaire was designed using the discrete choice experiment.A mixed Logit regression model was constructed for preference analysis.

The preference attributes for central vascular access devices in breast cancer patients undergoing chemotherapy included cost,concealment,catheterization time,and the incidence rate of complications.Different ages,educational levels,monthly income,social frequency,and surgical history of patients had different preferences for central vascular access device(all P<0.05).

Cost is the most concerned attribute for breast cancer patients when choosing central vascular access device.Medical staff should pay attention to the different preferences of breast cancer patients when choosing central vascular access device,and provide professional guidance to help them make decisions on central venous vascular access devices that meet their own needs,thereby improving the medical experience and quality of life.