Full
Outline
To explore the risk factors for patients complicated with perianal infection after allogeneic hematopoietic stem cell transplantation,and to construct and verify the risk prediction model.
A total of 259 patients who underwent allogeneic hematopoietic stem cell transplantation at a tertiary grade A hospital in Chongqing from January 2019 to December 2023 were selected as the modeling group.Relevant risk factors were screened through univariate and multivariate analyses,and a risk prediction model was constructed using R language.A total of 75 patients who underwent allogeneic hematopoietic stem cell transplantation in hospital from January 2024 to March 2025 were selected as the validation group.The model was evaluated and validated using the receiver operating characteristic curve area(AUC),Hosmer-Lemeshow goodness-of-fit test,decision curve analysis,and validation of the prediction model adopted.
The incidence of perianal infection in the modeling group was 18.53%,while that in the validation group was 24.00%.The risk factors of perianal infection after allogeneic hematopoietic stem cell transplantation included the history of perianal diseases,diarrhea,duration of neutropenia,and preoperative prognostic nutritional index.A predictive model for perianal infection after allogeneic hematopoietic stem cell transplantation was constructed based on these risk factors.The AUC value of the modeling group was 0.773,with a sensitivity of 0.604,a specificity of 0.853,and a maximum Youden index of 0.457.The AUC value of the validation group was 0.726,with a sensitivity of 0.745,a specificity of 0.897,and a maximum Youden index of 0.442.The decision curve analysis indicated that this model had good clinical benefits within a wide range of risk threshold probabilities.
The predictive model for patients complicated with perianal infection after allogeneic hematopoietic stem cell transplantation has excellent predictive performance.It could provide a scientific basis for the early assessment of perianal infection after allogeneic hematopoietic stem cell transplantation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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