Childhood tic disorders (TD) are complex neurodevelopmental disorders, with core pathological mechanisms closely linked to dopaminergic system dysfunction. In recent years, traditional Chinese medicine (TCM) has demonstrated advantages such as holistic regulation multi-target and multi-pathway intervention in the prevention and treatment of pediatric TD. The dopaminergic signaling pathway plays a pivotal role in the onset and progression of TD. By regulating the functions of dopamine D1/D2 receptors, the expression of dopamine transporter (DAT), the activity of dopamine-metabolizing enzymes, and synaptic plasticity, TCM can restore the homeostasis of neurotransmitters and thereby alleviate tic symptoms. Formulas such as Tianma Gouteng Decoction, Jianpi Zhidong Decoction, Ningdong Granules and Chaihu Plus Longgu Muli Decoction can participate in reconstructing the homeostasis of the dopaminergic system and relieve tics. Specifically, they act by balancing the function of D1/D2 receptors, modulating DAT expression, regulating the activity of dopamine-metabolizing enzymes such as COMT and MAO-B, as well as optimizing the expression of synaptic-related proteins and the function of neural circuits. This article reviews the mechanisms of active ingredients of Chinese medicinal herbs, TCM compound prescriptions and proprietary Chinese medicines in treating pediatric TD via regulating the dopaminergic signaling pathway, aiming to provide theoretical basis and research ideas for the prevention and treatment of TD with TCM.

Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor with relatively high incidence rate, and radiotherapy is its main treatment method. However, the effect of radiotherapy is affected by many factors, so increasing the radio-sensitivity is an important goal of clinical treatment. Traditional Chinese medicine compound and traditional Chinese medicine monomer can effectively play the role of reducing toxicity and increasing efficiency through multi-target and multi-channel role mechanism and have potential value on radio-sensitivity of NPC. This paper aims to review the research progress on application of traditional Chinese medicine compound and traditional Chinese medicine monomer in the intervention of NPC radio-sensitivity in recent years, summarize the role mechanism and clinical results of traditional Chinese medicine compound and traditional Chinese medicine monomer for NPC radio-sensitivity and explore the limitations of existing research and future development direction, in order to provide reference for clinical practice and in-depth research of NPC radio-sensitivity.

Acupoint needle-embedding demonstrates definitive therapeutic effects and high safety in the treatment of simple obesity. It effectively reduces patient body weight, BMI, waist circumference, body fat percentage, and other indicators. When combined with methods such as traditional Chinese medicine or Tuina, it produces synergistic effects. The clinical efficacy is influenced by the depth of embedding and the treatment frequency. Acupoint needle-embedding achieves weight loss through multiple pathways, including ameliorating leptin resistance, regulating peripheral fat metabolism, alleviating chronic inflammatory responses, and correcting intestinal flora disturbances. Current research still has limitations, such as short follow-up periods and insufficient procedural standardization. Future efforts should be directed toward rigorous clinical and mechanistic studies to enhance the standardization and precision of this therapy.

This paper elaborates on the theoretical connotations of Professor Zhang Boli's "Dampness-Turbidity-Phlegm-Fluid Retention Diseases". These disorders often arise from modern lifestyle changes that cause dysfunction in spleen transportation, impaired regulation of the Triple Burner (Sanjiao), and obstacles in lipid metabolism, leading to abnormal body fluid metabolism. Given that dampness, turbidity, phlegm, and fluid retention often intertwine and are difficult to resolve, simply differentiating a single pathogen is insufficient for guiding complex clinical practice. Therefore, it is necessary to explore the nuanced pathological mechanisms where multiple factors intersect. This study focuses on elucidating four complex pathological patterns: the coexistence of dryness and dampness, the intermingling of clear and turbid, the simultaneous pathology of blood and water, and the divergent transformation of qi and fluids. For the coexistence of dryness and dampness, treatment should prioritize nourishing Yin and moistening dryness without aggravating dampness, while resolving phlegm and drying dampness without damaging Yin. In cases of intermingling of clear and turbid, simultaneous ascending of the clear and descending of the turbid is essential. For blood-water co-pathology, therapeutic strategies should follow the principle of "harmonizing with warm-natured medicinals." In scenarios of divergent Qi-fluid transformation, methods to fortify the spleen and uplift Yang are warranted. This study refines the theoretical framework of these disorders, revealing the laws governing their complex pathogenesis, and provides novel insights for the precise diagnosis and treatment of related refractory diseases.

To investigate the antidepressant effects of Zhizi Chi Decoction (ZZCD) on depression-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats and to elucidate the underlying mechanisms.

Diabetes mellitus erectile dysfunction (DMED) , as a common complication of diabetes mellitus, has become a non-negligible health problem for male diabetic patients due to its complex pathogenesis and protracted, refractory course. Based on the "dryness-heat and stagnation" theory, this paper holds that the core pathogenesis of this disease is "damage to yin caused by drynessheat, failure of qi and body fluid to disperse, and loss of function of zongjin (penile erectile tissues)", and the disease can be divided into three stages: firstly, yin deficiency with dryness-heat injures zongjin internally, which mediates the onset of the disease; secondly, blockage of Xuanfu and stagnation of collaterals lead to the failure of qi and body fluid to disperse, accelerating the progression of the disease; thirdly, deficiency of healthy qi and lingering pathogens, along with the intermingling of deficiency and stasis, affect the prognosis of the disease. In treatment, the pathogenesis must be strictly adhered to: for the early stage of DMED, the treatment focuses on clearing heat and moistening dryness, nourishing yin and moistening zongjin to address the root cause, and the modified Baihu decoction combined with Zengye decoction is selected; for the middle stage of DMED, the therapy aims at opening Xuanfu and dredging collaterals, dispersing qi and body fluid to restore the function of zongjin, and the modified Liuwei Dihuang decoction combined with Shengjiang powder is used; for the late stage of DMED, the treatment emphasizes benefiting qi and activating blood circulation, and adopts the combination of unblocking and tonifying to consolidate the root, with the modified self-formulated Fuyuan Qiwei decoction. Throughout the entire treatment process, the core therapeutic principles of "clearing, dispersing, dredging, and tonifying" are implemented, and this study is expected to provide a new perspective and reference for the syndrome differentiation and treatment of DMED with traditional Chinese medicine.

Professor Wu Yaonan has been engaged in clinical practice of traditional Chinese medicine for over 40 years and has accumulated extensive experience in medicinal application, demonstrating particular ingenuity in the treatment of spleen-stomach disorders. This article systematically reviews Professor Wu's medical records in the clinical diagnosis and treatment of spleen-stomach diseases, summarizes his distinctive medicinal experience in pattern differentiation and treatment of these conditions, and categorizes his commonly used characteristic herbs according to their main effects into four groups: clearing heat, promoting diuresis, and stopping diarrhea (Bidens pilosa, Acalypha australis, Pteris multifida) ; detoxifying, activating blood circulation, and dissipating nodules (Actinidia arguta roots, Salvia chinensis, Zanthoxylum nitidum, Rostellularia procumbens) ; soothing the liver, regulating qi, and relieving depression (Akebia quinata, Hypericum sampsonii) ; and promoting tissue regeneration, healing sores, and alleviating pain (Membrana follicularis ovi) . The usage and precautions for each medicinal are also summarized.