Professor Xie Lin points out that the core pathogenesis of cervical spondylosis lies in the blockage of muscles, bones, and blood vessels, as well as the malnutrition of the muscles and bones. In clinical practice, the diagnosis and treatment should be based on the four diagnostic methods, to clarify the condition of deficiency or excess, and differentiate the symptoms. The treatment principle should focus on muscles and bones, with the main strategy being the elimination of excess and supplementation of deficiency, and the active use of horn medicine. In cases of wind, cold, phlegm, and blood stasis blocking the channels, it is necessary to expel the pathogenic factors, unblock the channels, and benefit the muscles and bones. When the internal organs are deficient in qi and blood, the treatment should aim to nourish the base, supplement deficiency, and nourish the muscles and bones. Additionally, associated symptoms should be considered, and treatments for muscle relaxation, liver wind elimination, and the relaxation of muscles and tendons should be used. Clinical practice has shown good results, as evidenced by the case examples provided.

Tic disorders often co - occur with sleep disorder, mood disorder, learning disorder and other physical and mental diseases, it's characterized by spirit - body disharmony, can be classified as Jueyin wind wood disease. The theory of Jueyin Conghua is believed that Jueyin wind wood is smooth and follows the Shaoyang phase fire, if the wood qi is smooth, the phase fire will transform into the wind wood. Guided by the "Jueyin Conghua theory", the professor Cui xia argues that the key to the pathogenesis of tic disorders and comorbidities lies in the compromised Jueyin pivotal mechanism and aberrant Conghua. The tendency of disease depends on the rise and fall of Jueyin phase fire. If it is too high, the wood will produce fierce wind from fire, and if it is too low, cold and heat will be mixed to generate wind In cases of acute and severe tics, the treatment must concentrate solely on regulating the body, with minor attention to the spirit, prioritizing the method of subduing yang and extinguishing wind. For chronic and mild tics presenting with comorbidity, a concurrent treatment approach is required. This entails simultaneous harmonization of both body and spirit, through dispersing stagnation and nourishing to pacify wind, thereby regulating the qi and blood of the root organ. At the same time, methods such as breath and mental regulation, daoyin (Therapeutic Exercise) and tuina (Chinese medical massage), and spiritual cultivation should be integrated to achieve a combined internal and external therapeutic strategy, enabling a comprehensive intervention for the condition. A case is attached for clinical reference.

Pediatric sinusitis is prevalent among children, which is mainly manifested by a large amount of turbid nasal discharge. Western medicine treats this disease mostly with oral antibiotics and nasal hormones, which have the disadvantages of uncertain efficacy and drug resistance. Traditional Chinese Medicine (TCM) treats this disease through oral and external use of Chinese herbal drugs, offering a relatively safe and low - side - effect treatment option. In this study, we believe that the onset of pediatric sinusitis is related to the external pathogens to the lungs closing to the surface and inside; the heat of the gallbladder leading to the congestion of the nose and orifices; spleen and stomach disorders causing to the imbalance of qi movement. The primary pathogenesis involves internal heat stagnation and obstruction of the nasal passages. The following methods should be used in treating this disease: to resolve the pathogens both external and internal, to dispel external evils and clear the heat in the lungs at the same time; pungent and bitter medicines should be used together, to relieve the heat in the gallbladder; to elevate the clearness and lower the turbidity, regulating the spleen and the stomach Qi. Tongqiao Shengjiang Powder is derived from "Shengjiang Powder", a classic formula for treating epidemics, and is modified by the addition of Magnolia biondii Pamp., ueraria lobata(Willd.) Ohwi, and Glycyrrhiza uralensis Fisch. This formula has excellent therapeutic effects for treating pediatric sinusitis. It has the efficacy of resolving external pathogens and clearing the heat in the lungs, elevating the clearness and lowering the turbidity, and improving nasal ventilation. Although its medicinal flavor is simple, the formula is comprehensive and covers several treatments. It can effectively treat pediatric nasosinusitis of various TCM syndrome types through addition or subtraction. In this paper, one case is attached for clinical reference.

This article is intended to introduce Professor Zhang Xikui's experience in diagnosing and treating gout. In the acute stage of gout, Baihu and Guizhi decoction is prescribed, supplemented with herbs that clear heat and eliminate dampness, cool blood and detoxify, and promote joint circulation. In the remission stage of gout, the formula for tonifying qi and unblocking collaterals is prescribed, supplemented with herbs that reduce phlegm and remove blood stasis, promote yang and cool the blood, resolve nodules and open collaterals, and invigorate the spleen and kidneys. According to the severity of pain and the course of the disease, the Shaoyao Gancao decoction is flexibly combined. Based on the severity of heat, dampness, phlegm, blood stasis, and deficiency, the treatment methods and medications are adjusted. It is also emphasized that the medication should be consistent and attention should be paid to lifestyle regulation.

Objective: To investigate the therapeutic effect of the Spleen - strengthening, Dampness - eliminating, and Turbidity - resolving Formula on patients with Spleen deficiency and damp - phlegm type polycystic ovary syndrome(PCOS) complicated by insulin resistance (IR).Methods: A total of 104 patients diagnosed with Spleen deficiency and damp - phlegm type PCOS complicated by IR were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine between April 2021 and April 2024. They were randomly assigned to the control group (n = 52, conventional treatment) and the Traditional Chinese Medicine (TCM) group (n = 52, receiving Spleen - strengthening, Dampness - eliminating and Turbidity - resolving Formula in addition to the control group treatment). Hormonal indicators, glucose and lipid metabolism indicators, TCM syndrome scores, imaging indicators, and the incidence of adverse reactions were compared before and after treatment.Results: After treatment, the FSH level in the TCM group was higher than that in the control group, while the levels of LH, AMH, LH/FSH, FPG, FINS, and HOMA - IR were lower (P < 0.05). The TCM group also showed lower scores for symptoms such as loose stools, diarrhea, loss of appetite, and fatigue compared to the control group (P < 0.05). Additionally, the ovarian volume and number of follicles in the TCM group were lower, while the endometrial thickness was higher than those in the control group (P <0.05). The incidence of adverse events in the TCM group did not differ statistically from that in the control group (P >0.05).Conclusion: The spleen - strengthening, dampness - eliminating, and turbidity - resolving formula can significantly improve metabolic status and enhance insulin sensitivity in patients with spleen - deficiency and phlegm- dampness type PCOS combined with IR. It is safe and holds great potential for broad clinical application and precision medicine.

Objective: To explore the clinical efficacy and mechanism of modified Ermiao Pills in improving refractory proteinuria of diabetic kidney disease(DKD) based on the ""Damp - Heat Damaging Kidney"" theory.Methods: A total of 126 patients with diabetic kidney disease were selected from the TCM department and nephrology department of Gulou Hospital affiliated to Nanjing University Medical School from January 2022 to January 2025. All patients were divided into the treatment group (Group A, n = 63) and the control group (Group B, n = 63) using a stratified randomization method with sealed envelopes. Group A received conventional basic treatment combined with modified Ermiao Pills, while Group B received only conventional basic treatment. Clinical assessments were conducted on enrollment day and at week 8 of treatment to evaluate TCM syndrome scores [including polydipsia, limb edema, sticky mouth, and epigastric distension], detect urinary protein profiles [24 - hour urine protein (24hUpro), urinary albumin (UAlb), urinary kidney injury molecule-1 (UKim - 1), urinary N - acetyl - β - D - glucosidase (UNAG)], analyze metabolomics parameters [palmitic acid, L - carnitine, phosphatidylcholine (PC), diacylglycerol (DG)], assess renal function[blood creatinine (Scr), blood urea nitrogen (BUN)], and evaluate safety indicators [red blood cells (RBC), alanine aminotransferase (ALT), albumin (Alb), glycated hemoglobin (HbA1c)]. The clinical efficacy of both groups was compared.Results: After treatment, compared with group B, the scores of polydipsia, limb edema, sticky mouth, epigastric and abdominal distension in group A, as well as the levels of 24hUpro, UAlb, UM - 1, UNAG, palmitic acid, Scr, BUN, were decreased (P < 0.05), while the levels of L - carnitine, PC and Dg were increased (P <0.05). Compared with group B, the total effective rate of group A increased (P <0.05).Conclusion: For the first time in a single - center randomized controlled trial, the combination of modified Ermiao pills and conventional treatment based on the ""damp - heat injuring kidney"" theory has been demonstrated to significantly improve refractory proteinuria in diabetic nephropathy, regulate metabolomic indicators, and protect renal function with high safety. Palmitic acid, L - carnitine, PC, and Dg may serve as potential therapeutic targets for modified Ermiao pills in treating refractory proteinuria of diabetic nephropathy.

Objective: To analyze on the effect of Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction in the treatment of patients with limb movement disorders (Qi deficiency and blood stasis syndrome) after stroke.Methods: 172 patients with post stroke limb movement disorders (Qi deficiency and blood stasis syndrome) admitted to Zhengzhou Central Hospital from January 2021 to March 2023 were randomly divided into 4 groups. All four groups received routine treatment, and the acupuncture group was additionally treated with Tongyuan acupuncture, and the Decoction group was additionally treated with modified Yiqi Tongluo Decoction, while the combination group was additionally treated with Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction. All four groups were treated for 3 months. Scores of traditional Chinese medicine symptoms, degrees of neurological deficit, limb motor functions and daily living abilities, clinical efficacy, hemorheological changes and safety were observed.Results: After treatment, the main symptoms, secondary symptoms, tongue pulse and total scores, NIHSS scores, blood viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and red blood cell aggregation indexes of the four groups all decreased (P <0.05), which were lowest in the combination group, higher in the acupuncture group and B, highest in control group (P <0.05). After treatment, the Fugl - Meyer and BI scores in all four groups increased (P <0.05), and those of the combination group were higher than the other three groups (P < 0.05), of which the acupuncture group and the Decoction group were both higher than the control group (P <0.05). The total effective rate of the combination group was highest (97.50%), followed by the acupuncture group and B (80.00%, 82.50%), lowest in control group (63.42%). The incidences of adverse reactions were consistent among the four groups (P >0.05).Conclusion: For patients with limb movement dysfunction (Qi deficiency and blood stasis syndrome) after stroke, Tongyuan acupuncture and modified Yiqi Tongluo Decoction can alleviate symptoms, enhance efficacy, and improve blood rheology. Moreover, the combination of the two has a better effect, with safety.

Objective: To analyze the curative effect of Huanglian Heye Formula combined with dulaglutide and its influences on insulin resistance and visceral fat index in patients with obese type 2 diabetes mellitus (T2DM) of damp heat affecting spleen type.Methods: A total of 80 patients with obese T2DM of damp heat affecting spleen type admitted to Foshan Fosun Chancheng Hospital were enrolled between January 2023 and December 2024. According to random number table method, they were divided into control group (dulaglutide) and combination group (Huanglian Heye Formula combined with dulaglutide), 40 cases in each group. All patients were treated for 12 weeks. The curative effect, blood glucose indexes [2 h postprandial blood glucose (2hPG), glycated hemoglobin (HbA₁c), fasting plasma glucose (FPG)], insulin resistance index (HOMA - IR), scores of TCM syndromes, obesity indexes and adverse reactions in the two groups were compared before and after treatment.Results: The curative effect of combination group was better than that of control group (P <0.05). After treatment, blood glucose indexes, HOMA - IR, scores of TCM syndromes and obesity indexes were decreased in both groups (P < 0.05), and FPG, 2 hPG, HbA₁c, HOMA - IR, scores of TCM syndromes, body fat percentage and visceral fat index in combination group were lower than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion: Curative effect of Huanglian Heye Formula combined with dulaglutide is good in patients with obese T2DM of damp heat affecting spleen type, which can lower blood glucose, improve insulin resistance, TCM syndromes and reduce visceral fat index.

Objective: To analyze the clinical efficacy of acupoint application combined with doxycycline in the treatment of mycoplasma pneumoniae pneumonia (MPP) complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome.Methods: A total of 120 children with MPP complicated with lung consolidation and phlegm - heat obstructing the lung syndrome, admitted to Shandong University Qilu Hospital Dezhou Hospital from August 2022 to August 2024, were selected. They were divided into a control group (doxycycline) and an observation group (control group treatment plus acupoint application) using a random number table method, with 60 cases in each group. The treatment course was 10 days. The therapeutic efficacy, symptom disappearance time, hospitalization duration, traditional Chinese medicine (TCM) syndrome scores, inflammatory factors [D - dimer (D - D), interleukin - 6(IL - 6), erythrocyte sedimentation rate (ESR), immunoglobulin - E (IgE), and C - reactive protein (CRP)], and adverse reactions were observed in both groups.Results: The total effective rate in the observation group was higher than that in the control group (P < 0.05). The time to symptom disappearance and the hospitalization duration in the observation group were shorter than those in the control group (P < 0.05). After treatment, the TCM syndrome scores and serum levels of inflammatory factors in the observation group were lower than those in the control group (P <0.01). There was no statistically significant difference in adverse reactions between the two groups (P > 0.05).Conclusion: Acupoint application combined with doxycycline for treating MPP complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome can alleviate symptoms and inflammatory injury and shorten the hospitalization duration, representing an effective and safe treatment regimen.

Objective: To investigate the efficacy of Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction in the treatment of phlegm - fire disturbing the heart type of intractable insomnia and its effect on sleep structure.Methods: Retrospectively selected 92 cases of recalcitrant insomnia patients treated in our hospital as research subjects, the selected time period is January 2022 - October 2024, according to the different treatment methods are divided into 40 cases in the control group (eszopiclone tablets) and 52 cases in the experimental group (control group + Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction). The clinical efficacy, TCM scores, sleep structure and sleep quality of the two groups were compared. Safety was analyzed for both groups.Results: After treatment, the effective rate of the experimental group was 96.15%, which was significantly higher than that of the control group, which was 80.00% (P < 0.05). After treatment, the scores of sleep and wakefulness, difficulty in falling asleep, sleeplessness after waking up, and restlessness and dreaminess in the experimental group were significantly lower than those in the control group (P <0.05). After treatment, the levels of rapid eye movement(REM) and non - rapid eye movement (N3) were significantly higher in the experimental group than in the control group (P < 0.05); the levels of non - rapid eye movement (N1) and non - rapid eye movement (N2) were significantly lower in the experimental group than in the control group (P < 0.05). After treatment, patients in the experimental group had significantly lower pulmonary daytime dysfunction, sleep onset, sleep duration, sleep disorder, sleep quality, sleep effectiveness and total score than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the experimental group was 15.38% (8/52), higher than the control group's 10.00%(4/40), but there was no significant difference between the two groups (P > 0.05).Conclusion: The combination of traditional Chinese medicine and western medicine (based on the treatment of estazolam tablet and Chaihu plus Longguand Muli Decoction combined with Huanglian Wendan Decoction) has a significant synergistic effect on refractory insomnia of phlegm fire disturbing heart type, which can not only achieve more satisfactory curative effect, but also effectively improve the symptoms of traditional Chinese medicine, significantly improve the sleep quality, optimize the sleep structure, and have higher safety, reflecting the advantages of integrated traditional Chinese and western medicine in the treatment of this disease.