To observe the therapeutic effects of Yiqi Yangyin Huayu Decoction on ventricular arrhythmia (VA) of Qi and Yin deficiency type.

A Total of 80 patients with VA of Qi and Yin deficiency type admitted to Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from March 2023 to March 2025 were selected and assigned into the control group (40 cases, conventional Western medicine) and the test group (40 cases, with the addition of Yiqi Yangyin Huayu Decoction on top of the control group) through the random number table. The therapeutic effect, cardiac function, electrocardiogram indicators, serological indicators, and adverse drug reaction (ADR) were compared.

Comparing total effective rate, the test group was higher than the control group (P<0.05). After therapy, the left ventricular ejection fraction (LVEF) of both groups raised compared with that before therapy, and with the test group being greater than the control group (P<0.05). The left ventricular end-diastolic diameter (LVEDD), QT interval, QT dispersion, galectin-3 (Gal-3), poly (ADP-ribose) polymerase 1 (PARP1), and soluble tumor necrosis factor receptor 1 (sTNFR1) in both groups decreased compared with those before therapy, and the values in the test group were smaller than those in the control group (P<0.05). There was no statistical difference in the total incidence of ADR between two groups (P>0.05).

Yiqi Yangyin Huayu Decoction can achieve good results in treating VA of Qi and Yin deficiency type. It can improve cardiac function and electrocardiogram indicators, reduce Gal-3, PARP1 and sTNFR1, and does not raise the occurrence of ADR.

To investigate the intervention efficacy and underlying mechanism of Modified Danggui Shaoyao Powder on steroid-related adverse reactions in children with nephrotic syndrome.

A total of 64 children with newly diagnosed nephrotic syndrome admitted to the Pediatric Ward of Heilongjiang Provincial Hospital of Traditional Chinese Medicine from October 2024 to December 2025 were enrolled and randomly divided into an observation group and a control group using a random number table, with 32 cases in each group. Both groups received routine basic treatment for nephrotic syndrome plus standardized glucocorticoid therapy. In addition, the control group received Huaiqihuang Granules, while the observation group received Modified Danggui Shaoyao Powder. The treatment course lasted 8 weeks. The following parameters were observed and compared between the two groups at three time points: T1 (at the time of achieving dry weight), T2 (14 days after achieving dry weight), and T3 (after 8 weeks of full-dose steroid therapy): Yin deficiency and internal heat syndrome scores, body fat-related indicators (BMI and waist-to-height ratio [WHtR]), HPA axis function indicators (cortisol [COR], adrenocorticotropic hormone [ACTH], 24-hour urinary free cortisol [24 hUFC], and low-dose dexamethasone suppression test [LDST]), and bone metabolism markers (25-hydroxyvitamin D[25(OH)D] and procollagen type I N-terminal propeptide [P1NP]).

At T1, there were no significant differences between the two groups in syndrome scores, BMI, WHtR, HPA axis indicators, or bone metabolism markers (P>0.05). At T2 and T3, the observation group showed significantly lower Yin deficiency and internal heat syndrome scores than the control group (P<0.01). At T3, the observation group had significantly lower BMI and WHtR (P<0.01), and significantly higher levels of COR, 24 hUFC, LDST, 25 (OH) D, and P1NP compared with the control group (P<0.05, P<0.01).

Modified Danggui Shaoyao Powder can effectively alleviate the Yin deficiency and internal heat syndrome manifestations induced by glucocorticoid therapy in children with nephrotic syndrome, and attenuate steroid-induced abnormalities in body fat metabolism, HPA axis suppression, and bone metabolism disorders, thereby exerting a counteractive effect against steroid-related adverse reactions.

To investigate the effects of modified Huangqi Jianzhong Decoction combined with conventional treatment on intestinal function, intestinal barrier, and immune-inflammatory status in patients after laparoscopic colorectal cancer surgery, and to provide evidence-based support for enhanced recovery.

A total of 96 patients who underwent laparoscopic radical resection for colorectal cancer at Wujin Affiliated Hospital of Nanjing University of Chinese Medicine from February 2022 to March 2025 were randomly divided into an observation group and a control group, with 48 cases in each group. The control group received conventional treatment. On this basis, the observation group was additionally given modified Huangqi Jianzhong Decoction starting from the first day after surgery, one dose per day for 7 consecutive days. Clinical efficacy was compared between the two groups. Traditional Chinese Medicine (TCM) syndrome scores, intestinal barrier function indicators (diamine oxidase [DAO], D-lactic acid [D-Lac], intestinal fatty acid-binding protein [IFABP]), immune-inflammatory indicators (CD4⁺/CD8⁺ ratio, natural killer [NK] cell activity, regulatory T cells [Treg], IL-10/IL-6 ratio), and the Gastrointestinal Symptom Rating Scale (GSRS) scores were compared before surgery and 7 days after surgery. Postoperative complications and adverse events were also recorded.

On postoperative day 7, the total effective rate in the observation group was 95.83% (46/48), which was significantly higher than that in the control group (72.92%, 35/48) (P<0.01). Compared with postoperative day 1, the levels of DAO, D-Lac, and IFABP in both groups decreased on postoperative day 7 (P<0.05), and the levels in the observation group were significantly lower than those in the control group (P<0.05). The CD4⁺/CD8⁺ ratio, NK cell activity, Treg percentage, and IL-10/IL-6 ratio increased significantly in both groups (P<0.05), with the observation group showing significantly higher values than the control group (P<0.05). The scores for abdominal pain, abdominal distension, difficulty in passing flatus, nausea/reflux, and defecation disorder in the observation group were significantly lower than those in the control group (P<0.01). In the control group, one patient experienced postoperative nausea and dizziness, and one patient developed pruritic erythema; in the observation group, one patient experienced nausea and decreased appetite. There was no significant difference in adverse events between the two groups (P>0.05). The incidence of complications in the observation group was 6.25% (3/48), which was significantly lower than that in the control group (20.83%, 10/48) (P<0.05).

Adding modified Huangqi Jianzhong Decoction to conventional treatment can significantly improve intestinal barrier function, immune-inflammatory balance, and gastrointestinal symptoms in patients after laparoscopic colorectal cancer surgery, and reduce the incidence of complications, with a favorable safety profile.

To investigate the clinical effects of Huayu Ditan (resolving blood stasis and eliminating phlegm) therapy in treating patients with acute ischemic stroke (AIS) with phlegm and stasis paralysis obstruction, and the effects on the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and B-lymphoblastoma-2 (Bcl-2) in the peripheral blood.

Based on the random arrangement table method, 90 cases of phlegm stasis paralysis-type AIS patients admitted to Luohe Hospital of Traditional Chinese Medicine from June 2022 to June 2024 were divided into the control group (n=45, conventional western medicine treatment) and the observation group (n=45, combined with the method of resolving stasis and purging phlegm on the basis of the control group), and assessed and compared the clinical efficacy, Chinese medicine symptom scores, blood rheology, oxidative stress, and the levels of other biochemical indicators and the incidence of adverse reactions in both groups.

The total effective rate of treatment in the observation group (91.11% vs. 75.56%) was higher than that in the control group, and the difference was statistically significant (P<0.05); on the next day after the end of the treatment, the levels of superoxide dismutase, glutathione peroxidase, and Bcl-2 were higher than those before the treatment in the two groups, and the observation group was higher than that in the control group, and the levels of numbness of the limbs, whole-blood viscosity [high cut and low cut], shortness of breath and fatigue, crookedness of the mouth and tongue, plasma Viscosity, speech allusion, HIF-1α and fibrinogen water were lower than before treatment on average, and the observation group was lower than the control group (P<0.05); the incidence rate of adverse reactions in the two groups (13.33% vs. 8.89%) was compared with each other, and the difference was not statistically significant (P>0.05).

The treatment of AIS patients with the method of resolving blood stasis and eliminating phlegm has high clinical efficacy, which can reduce patients' disease symptoms and oxidative stress, and improve haematological rheology while regulating the expression levels of HIF-1α and Bcl-2, with a high degree of safety.

To investigate the efficacy of modified Shechuangzi Powder fumigation and washing combined with high-intensity focused ultrasound (HIFU) in the treatment of vulvar leukoplakia (WLV) and its effects on traditional Chinese medicine (TCM) syndrome scores and nerve growth factor (NGF) levels in patients.

A total of 196 WLV patients with liver-kidney yin deficiency pattern treated at Hengshui Maternal and Child Health Hospital from January 2023 to June 2024 were selected and randomly divided into a combination group and a control group using a random number table method, with 98 cases in each group. Due to loss to follow-up, 1 case in the combination group and 2 cases in the control group were excluded, resulting in 97 and 96 cases being included in the final statistical analysis, respectively. The control group received HIFU treatment, while the combination group received additional modified Shechuangzi Powder fumigation and washing on the basis of HIFU. The therapeutic efficacy, TCM syndrome scores, and Dermatology Life Quality Index (DLQI) scores were evaluated before and after treatment. Serum and vulvar tissue-related indicators were measured before and after treatment. Adverse reactions and recurrence within 6 months of follow-up were recorded in both groups.

The total effective rate in the combination group was 100.00%, which was higher than that in the control group (90.63%) (P<0.01). After treatment, TCM syndrome scores and DLQI scores in the combination group were significantly lower than those in the control group (P<0.05). Regarding serum indicators, the levels of NGF, substance P (SP), C-reactive protein (CRP), and interleukin-6 (IL-6) in the combination group after treatment were significantly lower than those in the control group (P<0.05). Regarding vulvar tissue indicators, the optical density (OD) value of NGF positive expression in the combination group after treatment was significantly lower than that in the control group (P<0.05), while the OD value of vascular endothelial growth factor (VEGF) positive expression was significantly higher than that in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). The 6-month recurrence rate in the combination group was 3.09%, which was lower than that in the control group (10.42%) (P<0.05).

Modified Shechuangzi Powder fumigation and washing combined with HIFU is safe and effective in the treatment of WLV. It can significantly reduce TCM syndrome scores, down-regulate NGF and pro-inflammatory factor levels, upregulate VEGF expression, reduce the recurrence rate, and improve patients' quality of life.

To observe the efficacy of Qingbu Jiushen Formula combined with Western medicine in treating chronic kidney disease (CKD) with Qi-Yin deficiency and damp-heat internal retention, and its effects on peripheral blood levels of Cystatin C and pro-gastrin-releasing peptide (proGRP).

A total of 100 CKD patients with Qi-Yin deficiency and damp-heat internal retention admitted to the Department of Nephrology, Luoyang Hospital, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, from January 2022 to October 2024, were randomly divided into a Western medicine group and a combination group using the envelope method, with 50 cases in each group. The Western medicine group received routine Western medical treatment, while the combination group received Qingbu Jiushen Formula in addition to the same Western treatment, for 12 consecutive weeks. The following parameters were measured before and after treatment: 24-hour urinary protein (24 h Upro), estimated glomerular filtration rate (eGFR), urinary albumin excretion rate (UAER), serum creatinine (Scr), blood urea nitrogen (BUN), Cystatin C, proGRP, and factors related to the nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) signaling pathway. Traditional Chinese medicine (TCM) symptom scores were assessed before and after treatment, and the overall response rate and incidence of adverse reactions were recorded.

Before treatment, there were no significant differences between the two groups in 24 h Upro, eGFR, UAER, Scr, Cystatin C, or proGRP (P>0.05). After 12 weeks of treatment, 24 h Upro, UAER, Scr, Cystatin C, and proGRP decreased significantly in both groups compared with baseline (P<0.05), and the combination group showed significantly lower levels than the Western medicine group (P<0.05). eGFR increased significantly in both groups after treatment (P<0.05), with the combination group showing a higher eGFR than the Western medicine group (P<0.05). Regarding Nrf2-ARE pathway-related factors, no significant differences were found between the two groups at baseline (P>0.05). After 12 weeks, catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and glutathione peroxidase (GSH-Px) all increased significantly in both groups (P<0.05), and the combination group had significantly higher levels than the Western medicine group (P<0.05). TCM symptom scores were comparable between groups before treatment (P>0.05), but after 12 weeks both groups showed significant reductions (P<0.05), with the combination group scoring lower than the Western medicine group (P<0.05). The overall response rate in the combination group was 92.00% (46/50), which was higher than that in the Western medicine group (76.00%, 38/50). The incidence of adverse reactions was 12.00% (6/50) in the combination group versus 8.00% (4/50) in the Western medicine group, with no statistically significant difference (P>0.05).

Qingbu Jiushen Formula combined with Western medicine can improve renal function, regulate the Nrf2-ARE signaling pathway, and enhance therapeutic efficacy in CKD patients with Qi-Yin deficiency and damp-heat internal retention.

To analyze the clinical efficacy of modified Danggui Buxue Decoction on patients with qi and blood deficiency syndrome after postoperative chemotherapy for breast cancer.

A total of 98 breast cancer patients with qi and blood deficiency syndrome who underwent postoperative chemotherapy and were admitted to our hospital from February 2023 to January 2025 were randomly divided into two groups by random number table method. The control group was given conventional treatment, while the observation group was additionally treated with modified Danggui Buxue Decoction. The therapeutic effects of the two groups were compared.

The disease control rate (DCR) of the observation group was higher than that of the control group (P<0.05). After treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ and the quality of life score in the observation group were higher than those in the control group, while the level of CD8⁺ and the scores of each item of traditional Chinese medicine syndrome were lower than those in the control group (P<0.01). Comparison of the incidence of adverse reactions between groups (P>0.05). The patients were followed up for 6 months. The recurrence rate of the observation group was 4.08% (2/49), which was lower than that of the control group at 16.33% (8/49) (χ² value 4.009, P value=0.045).

The modified Danggui Buxue Decoction has a significant therapeutic effect on patients undergoing chemotherapy after breast cancer surgery. It can reduce the TCM syndrome score, improve immune function, enhance the quality of life of patients, and has a relatively low recurrence rate.

To study the clinical effect of traditional Chinese medicine therapy based on the theory of miscellaneous diseases and hidden pathogens in the treatment of elderly patients with lower extremity fractures complicated with pulmonary infection.

132 elderly patients with lower extremity fractures complicated with pulmonary infection who were admitted to Sichuan Province Orthopedic Hospital from March 2023 to January 2025 were selected and evenly divided into two groups by random single-blind method, including control group (66 cases, conventional western medicine therapy) and trial group (66 cases, traditional Chinese medicine therapy based on the theory of miscellaneous diseases and hidden pathogens in addition to control group). The TCM symptoms scores, clinical pulmonary infection score (CPIS), detection indicators, course of infection and adverse reactions were compared between the two groups.

After treatment, the scores of dimensions of primary syndromes and secondary syndromes in the two groups of patients were decreased (P<0.05), and the scores in trial group were lower than those in control group (P<0.05). After treatment, the scores of dimensions of CPIS were reduced in the two groups of patients (P<0.05), and the reductions in trial group were higher compared to control group (P<0.01). After treatment, the levels of inflammatory factors in both groups of patients were declined (P<0.05), and the levels were lower in trial group than those in control group (P<0.05). The course of infection in trial group was shorter than that in control group (P<0.05). There was no statistical difference in the occurrence of adverse reactions between the two groups (P>0.05).

For elderly patients with lower extremity fractures complicated with pulmonary infection who are differentiated as spleen deficiency and phlegm dampness and blood stasis, the implementation of traditional Chinese medicine therapy based on the theory of miscellaneous diseases and hidden pathogens is helpful to alleviate the symptoms of body discomfort, relieve the degree of pulmonary infection, reduce the levels of inflammatory factors, and shorten the time of antibiotic use, with high safety.

To investigate the correlation among cytokine levels, traditional Chinese medicine (TCM) syndromes, and clinical efficacy in patients with radiation-induced vaginitis after cervical cancer who were treated with heat-clearing and detoxifying herbal irrigation.

A total of 124 patients with radiation-induced vaginitis following cervical cancer admitted to our hospital from February 2023 to May 2025 were enrolled and randomly divided into a control group (n=62, receiving conventional vaginal douching) and an observation group (n=62, receiving heat-clearing and detoxifying herbal irrigation). Curative effect, adverse reactions, cytokine levels, TCM syndrome scores, and the correlations between cytokines and TCM syndromes or efficacy in the observation group were evaluated before and after treatment.

Following treatment, the observation group's (93.55 percent) overall effective rate was significantly greater than the control group's (80.64 percent) (P<0.05), and both groups' total effective rates exceeded 80%. There was no statistically significant difference between the observation group's (3.22 percent, P>0.05) and control group's (8.05 percent) overall incidence of adverse responses. Post-treatment, cytokine levels declined significantly in both groups (P<0.05), with the observation group experiencing a larger decline (P<0.05). All TCM syndrome scores were improved after treatment (P<0.05), and the improvement was superior in the observation group (P<0.05). In the observation group after treatment, only “profuse leukorrhea” showed a significant negative correlation with IL-6 level (P<0.01), while “yellow color with foul fishy odor” was positively correlated with IL-8 level (P<0.01).

Heat-clearing and detoxifying herbal irrigation can effectively ameliorate inflammatory symptoms and TCM syndromes in patients with radiation-induced vaginitis after cervical cancer, demonstrating favorable efficacy and safety, and is worthy of clinical application and promotion. The correlation results suggest that its mechanism may involve down-regulating inflammatory cytokines, thereby improving TCM syndromes and ultimately achieving better clinical outcomes.

To explore the clinical efficacy of Danggui Shaoyao Powder combined with low-dose low-molecular-weight heparin calcium in the treatment of early-onset severe preeclampsia.

96 patients with early-onset severe preeclampsia admitted to Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine from September 2022 to September 2024 were included.96 patients with early-onset severe preeclampsia were randomly divided into an observation group and a control group, with 48 cases in each group. The control group received subcutaneous injection of low molecular weight heparin calcium, while the observation group received treatment in combination with Danggui Shaoyao Powder. After one week of treatment, the traditional Chinese medicine syndrome scores, blood pressure, vascular endothelial cell adhesion molecule-1 (VCAM-1), angiotensinⅡ (AngII), coagulation indicators [thrombin time (TT), prothrombin time (PT), plasma fibrinogen (FIB), D-dimer], proteinuria [24-hour urine protein quantification, microalbumin (mAlb), transferrin (TRF), urinary alpha 1-microglobulin (α 1-MG)], perinatal outcomes, and adverse reactions were compared between the two groups.

After treatment, the scores of dizziness, headache, blurred vision, abdominal or chest discomfort, and edema decreased in both groups (P<0.05), and the observation group was lower than the control group (P<0.05). After treatment, both groups showed prolonged PT and TT (P<0.05), with the observation group exhibiting longer durations than the control group (P<0.05). Both groups experienced a decrease in FIB and D-dimer levels (P<0.05), with the observation group showing lower levels than the control group (P<0.05). After treatment, both groups showed a decrease in diastolic blood pressure, systolic blood pressure, serum VCAM-1, serum AngII, 24-hour urinary protein quantification, mAlb, TRF, and α 1-MG (P<0.05), with the observation group being lower than the control group (P<0.05). The gestational age of delivery in the observation group was longer than that in the control group (P<0.05), and the birth weight of newborns was higher than that in the control group (P<0.05). Additionally, the incidence of fetal growth restriction, fetal distress, and neonatal asphyxia was lower in the observation group than in the control group (P<0.05).

Danggui Shaoyao Powder in the treatment of early-onset severe preeclampsia helps alleviate clinical symptoms and improve perinatal outcomes.