To investigate the clinical effects of Huayu Ditan (resolving blood stasis and eliminating phlegm) therapy in treating patients with acute ischemic stroke (AIS) with phlegm and stasis paralysis obstruction, and the effects on the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and B-lymphoblastoma-2 (Bcl-2) in the peripheral blood.

Based on the random arrangement table method, 90 cases of phlegm stasis paralysis-type AIS patients admitted to Luohe Hospital of Traditional Chinese Medicine from June 2022 to June 2024 were divided into the control group (n=45, conventional western medicine treatment) and the observation group (n=45, combined with the method of resolving stasis and purging phlegm on the basis of the control group), and assessed and compared the clinical efficacy, Chinese medicine symptom scores, blood rheology, oxidative stress, and the levels of other biochemical indicators and the incidence of adverse reactions in both groups.

The total effective rate of treatment in the observation group (91.11% vs. 75.56%) was higher than that in the control group, and the difference was statistically significant (P<0.05); on the next day after the end of the treatment, the levels of superoxide dismutase, glutathione peroxidase, and Bcl-2 were higher than those before the treatment in the two groups, and the observation group was higher than that in the control group, and the levels of numbness of the limbs, whole-blood viscosity [high cut and low cut], shortness of breath and fatigue, crookedness of the mouth and tongue, plasma Viscosity, speech allusion, HIF-1α and fibrinogen water were lower than before treatment on average, and the observation group was lower than the control group (P<0.05); the incidence rate of adverse reactions in the two groups (13.33% vs. 8.89%) was compared with each other, and the difference was not statistically significant (P>0.05).

The treatment of AIS patients with the method of resolving blood stasis and eliminating phlegm has high clinical efficacy, which can reduce patients' disease symptoms and oxidative stress, and improve haematological rheology while regulating the expression levels of HIF-1α and Bcl-2, with a high degree of safety.