The experimental animals were divided into normal rats control group, normal rats Gyps group, hyperlipidemia rats control group, and hyperlipidemia rats Gyps group. The animals in control and Gyps groups were given blank solvent and Gyps for 7 days respectively. On the 8th day, the rats in each groups were given the probe drug (aminopterin). The effect of Gyps on CYP3A2 activity in normal and hyperlipidemic rats was analyzed by detecting blood concentration of probe drug using HPLC method and calculating pharmacokinetic parameters.

Compared with normal rats control group and hyperlipidemia rats control group, AUC, C_max of dapsone increased, t_1/2 was significantly prolonged, and CLz/F significantly decreased both in normal rats Gyps group and hyperlipidemia rats Gyps group (P <0.01). Compared with normal rats control group, AUC of dapsone in hyperlipidemia rats control group significantly increased and the CLz/F significantly decreased (P <0.01). After administration of Gyps, compared with normal rats Gyps group, the increase of AUC and decrease of CLz/F of dapsone in hyperlipidemia rats Gyps group were more significant (P <0.01).

The activity of CYP3A2 enzyme in rats can be inhibited by Gyps. The results suggest that the dosage of drug should be adjusted to avoid the potential risk of herb-drug interactions when Gyps is combined with drugs metabolized by CYP3A4, especially in hyperlipidemia.

To observe the clinical efficacy of modified Shangqing powder with channel-guiding herbs in the treatment of acute migraine attacks.

A total of 47 patients with acute migraine attacks who visited the outpatient department of Encephalopathy at Dongzhimen Hospital, Beijing University of Chinese Medicine between July 2023 and June 2024 were selected and divided into Group A and B using a random number table method. In the first phase (P1), Group A received Shangqing powder combined with ibuprofen, while Group B received a placebo combined with ibuprofen. After a washout period, the two groups switched treatments in the second phase (P2). Each patient received both intervention methods sequentially. The effective rate of treatment, VAS scores and accompanying symptom scores before and 2 hours, 24 hours after treatment, and short-term recurrence of migraine within 24 h and 72 h after medication were observed. The possible target points were further explored by comparing the changes of serum indicators before and after treatment.

In the P1, there were significant between-group differences in accompanying symptom scores at 24 hours, VAS scores at 24 hours, and the degree of reduction in VAS scores at 24 hours (P < 0.05). The difference in serum nitric oxide (NO) levels before and after treatment also showed significant between-group differences (P < 0.05, P < 0.01). In the P2, there were no statistically significant differences in VAS scores at 2 hours and 24 hours or accompanying symptom scores between the groups(P > 0.05). Across both phases, the efficacy rate of Shangqing powder at 2 hours post-treatment was 72.20%, significantly higher than the placebo's 34.20% (χ² =10.716, P =0.001). Significant differences were observed in VAS scores at 24 hours and accompanying symptom scores at 2 hours and 24 hours post-treatment (P <0.05), and the migraine recurrence rate within 72 hours was reduced (P <0.01).

Shangqing powder demonstrates good clinical efficacy in the treatment of acute migraine attacks, providing clinical reference for the intervention of migraines with traditional Chinese medicine.

To observe the clinical efficacy of Liu's Zhenggu DanⅠ orally combined with Xiaozhong ointment externally on simple rib fractures.

Ninety patients with simple rib fractures admitted to Wuxi Hospital of Traditional Chinese Medicine from July 2024 to January 2025 were randomly divided into two groups at a 1∶ 1 ratio:the experimental group (treated with Liu's Zhenggu DanⅠ orally and Xiaozhong ointment externally) and the conservative treatment group (treated with Western medicine), with 45 patients in each group. On the 7th and 14th day after treatment, VAS scores and serum inflammatory factor levels at the fracture site were observed, and the formation of rib fracture callus was observed one month after treatment to evaluate the treatment effect.

On the 7th and 14th day after treatment, VAS scores and levels of IL -1β, IL -6, and TNF-αin the experimental group were significantly lower than those in the control group (P <0.05). In addition, the experimental group showed significant advantages in both rib fracture healing rate and clinical efficacy improvement rate. (P < 0.05).

The combination of oral administration of Liu's Zhenggu DanⅠ and external application of Xiaozhong ointment can alleviate patient pain, inhibit systemic inflammatory response, shorten the healing time of simple rib fractures, and have significant clinical efficacy. It can provide a new option for the treatment of simple rib fractures, enrich clinical treatment methods, and provide value for the modern clinical application of traditional Chinese medicine bone injury therapy.

To study the effect of pharyngeal constrictor muscle strengthening training combined with traditional Chinese medicine rehabilitation on the feeding of food of different consistency in patients with swallowing disorders in the pharyngeal stage.

Ninety-five patients with swallowing disorders in pharyngeal stage included in our hospital from April 2022 to February 2024 were selected for observation, and grouped according to the randomized numerical table method. 47 cases in the study group received pharyngeal contraction muscle strengthening training combined with traditional Chinese medicine (TCM) rehabilitation, and 48 cases in the control group received pharyngeal contraction muscle strengthening training, and the results of clinical assessment of pharyngeal function were compared with those of the two groups, including the positive rate of the modified volumetric viscosity test (VVST-CV), the classification of the Functional Oral Intake Scale (FOIS), drinking test, and swallowing function clinical assessment results.

There was no difference in the results of FOIS and drinking test between the two groups before treatment (P >0.05), and after treatment, the FOIS grade of the study group was higher than that of the control group, but the drinking test grade was lower than that of the control group (P <0.01). There was no difference in the results of clinical assessment of swallowing function between the two groups before treatment (P >0.05), and after treatment, the incidence of effective cough was higher in the study group than in the control group, and the maximum respiratory time and the number of repeated salivary swallows were higher in comparison with the control group, but the time required for eating was less than that in the control group (P <0.01). The post-treatment positive rates of the study group for foods of different consistencies (No.1-3) were 29.79%, 14.89%, and 25.53%, respectively, all of which were lower than those of the control group, 64.58%, 45.83%, and 54.17% (P < 0.01).

For patients with swallowing disorders in the pharyngeal phase, transpharyngeal constrictor muscle strengthening training combined with Chinese medicine rehabilitation intervention is more effective, which can improve the swallowing function of patients eating food of different consistency, increase the effective cough, the longest respiratory time and the number of repeated salivary swallowing, and it is worth to be popularized and used in the clinic.

To establish an HPLC fingerprint of Viola yedoensis using HPLC technology, evaluate the quality of 10 batches of Viola yedoensis combined with cluster analysis (HCA) and principal component analysis (PCA), and study its anti-inflammatory mechanism.

A Waters Symmetry C18 column (250 mm × 4.6 mm, 5 μm) was used with a mobile phase of acetonitrile -0.1% phosphoric acid aqueous solution; flow rate: 0.8 mL·min^-1; injection volume: 10 μL; column temperature: 30 ℃; detection wavelength: 353 nm. The anti-inflammatory effect was observed using the ear swelling method, and the levels of PGE₂, IL -6, and TNF-α in serum were detected.

The HPLC fingerprint of 10 batches of Viola yedoensis was successfully established, with 10 common peaks identified. The similarities were all higher than 0.990. Two common peaks were identified as cichoriin (2.44 ± 1.11) mg·g^-1 and esculetin (10.50 ± 1.57) mg·g^-1. The 10 batches of samples were classified into two categories by chemical pattern recognition methods. The aqueous decoction of Viola yedoensis could inhibit ear swelling in mice and reduce the levels of TNF-α, IL-6, and PGE₂ in serum.

This study successfully established the HPLC fingerprint of 10 batches of Viola yedoensis and found that its anti-inflammatory mechanism may be related to the inhibition of TNF-α, IL-6, and PGE₂ expression, providing a scientific basis and pharmacodynamic support for the quality control and clinical application of Viola yedoensis.

To provide theoretical basis for basic research and clinical application of traditional Chinese medicine by analyzing the origins and characteristics of the compatibility of the Draconis Os and Ostreae Concha couplet medicinals.

Formulae involving the Draconis Os and Ostreae Concha couplet medicinals were collected and organized from the Chinese Medical Classics. Based on the theory of couplet medicinals compatibility, this study examines and verifies the origin of the Draconis Os and Ostreae Concha couplet medicinals from the perspective of historical application and compatibility mechanisms, and summarizes the usage characteristics including primary indications, dosage ratios, and preparation methods.

A total of 382 formulae containing the Draconis Os and Ostreae Concha couplet medicinals were identified, with applications in the treatment of mental disorders beginning from the Han Dynasty. Numerous classical texts record that this couplet medicinals is commonly used in equal ratios and the preparation methods often include, but are not limited to, fire processing. Historically and in modern clinical practice, this couplet medicinals is widely used across various fields including internal medicine, gynecology, and andrology. Modern research focuses on analyzing the effective components for calming the mind and their clinical therapeutic effects.

The Draconis Os and Ostreae Concha couplet medicinals has a broad clinical application potential, with a long history and rich experience in treating mental disorders. This research can provide valuable insights for modern clinical treatment and basic research in TCM.

To explore the clinical observation and effect of abdominal acupuncture therapy combined with Yangming meridian puncture in the treatment of diabetic peripheral neuropathy and nerve reflexes.

Selected 126 patients with diabetic peripheral neuropathy in the Department of Traditional Chinese Medicine, Xingtai Hospital of Traditional Chinese Medicine, from August 2022 to June 2024, grouped by the random number table method, 63 patients in the control group were treated with conventional medication + Yangming meridian rows of puncture therapy, and 63 patients in the experimental group were applied with abdominal acupuncture on the basis of the treatment in the control group, comparing the clinical effects of the two groups, evaluating the degree of symptomatic relief of the patients, the examination of the nerve conduction velocity determination, and the nerve reflexes. and nerve reflexes.

In this study, 1 case of 63 patients in the experimental group was excluded, 2 cases were shed, and 60 cases were finally included; 1 case of 63 patients in the control group was excluded, 1 case was shed, and 61 cases were finally included. The total effect rate of the experimental group was higher than that of the control group (P <0.05) ; there was no significant difference in the comparison of symptom scores, gastric emptying and BRU measurements, VPT and NCV of the lower limbs between the two groups before treatment (P > 0.05), and the symptom scores (limb numbness, pain, etc.) and the values of T1/2, BRU, and VPT were lower than those of the control group after the treatment of the experimental group(P <0.01), and the values of the peroneal nerve and the peroneal nerve's MNCV and SNCV were significantly higher than those of the control group (P > 0.05). The MNCV and SNCV values of peroneal nerve and common peroneal nerve were significantly higher than those of the control group (P <0.01) ; there was no significant difference in the scores of nerve reflexes before treatment between the two groups (P > 0.05) ; MDNS, NSS and MNSI scores of the experimental group were lower than those of the control group (P < 0.01).

The abdominal acupuncture therapy combined with the Yangming meridian puncture programme can effectively alleviate the clinical symptoms of patients with diabetic peripheral neuropathy, improve their gastric emptying function and bladder function, and enhance the nerve conduction velocity of the lower limbs of the patients, and reasonably optimize their nerve reflexes.