Objective: To analyze the therapeutic effect and immune mechanism of the Jianpi Yishen Huoxue Tongluo Paste Formula on the stable stage of chronic obstructive pulmonary disease (COPD).Methods: The clinical data of 83 COPD patients admitted to the outpatient service of Suzhou Integrated Chinese and Western Medicine Hospital during January, 2021 to August, 2023 were retrospectively analyzed. According to the different treatment methods, they were divided into control group (n = 40,Western medicine treatment) and observation group (n = 43,Western medicine +Jianpi Yishen Huoxue Tongluo Paste Formula),which were treated for 2 months. The clinical efficacy, adverse reactions, Chinese medicine symptom scores before and after treatment, dyspnea severity [modified British Medical Research Council Respiratory Questionnaire (mMRC)], symptoms [COPD Self - Assessment Test Questionnaire (CAT)], exercise endurance [6 - minute walking distance (6MWD)], and T helper cell 17(Th17)/regulatory T were compared between the two groups Cell (Treg) ratio, and the annual number of attacks 1 year before treatment and 1 year after treatment.Results: The total effective rate of observation group was 95.00%, which was higher than that of control group 76.32% (P <0.05). After treatment, the syndrome score, mMRC score,CAT score, annual number of attacks and Th17/Treg ratio were decreased in both groups, and the 6MWD value was increased, and the change was greater in the observation group compared with the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the control group(13.16%) and the observation group (5.00%) (P >0.05).Conclusion: The Jianpi Yishen Huoxue Tongluo Paste Formula is safer and more effective in the treatment of stable COPD It may exert its effect by affecting the Th17/Treg balance.

Jianpi Yishen Huoxue Tongluo Paste Formula  /  Chronic obstructive pulmonary disease  /  Stable pbase  /  Action mechanism