To explore the effects of Qingyan Runhou (throat-clearing and moistening) tea on the clinical symptoms and recurrence of children with chronic pharyngitis (lung-kidney yin deficiency syndrome).

A total of 112 children with chronic pharyngitis from January 2023 to October 2024 were selected as the subjects of this trial. Randomly divide it into 2 groups, 56 children in the control group were given Xuanmai Ganju granules, and 56 children in the treatment group were given clear throat and throat tea. After treatment, the efficacy, clinical symptoms, pharyngeal sign scores, immunological function, adverse reactions and recurrence rates of the two groups were compared.

Treatment group demonstrated a higher clinical efficacy rate than control group (P < 0.05). After treatment, the clinical symptom scores and pharyngeal sign scores of the two groups were lower than before, and treatment group was lower than control group (P < 0.05). After treatment, the levels of immunoglobulin A and immunoglobulin M of the two groups were lower than before, and treatment group was higher than control group (P <0.05). No statistical difference was found in thyroid function and adverse reactions between two groups (P > 0.05). Recurrence rate of the treatment group was lower than the control group (P <0.05).

Throat-clearing and throat-moistening tea has obvious effects on children with chronic pharyngitis syndrome of lung and kidney yin deficiency. It can improve clinical symptoms, enhance immunological function, and reduce the recurrence rate while ensuring safety.

To investigate the difference of expression levels of IL-4 and IL-18 in the brain tissue of insomnia model rats with 'kidney failing to store willpower' Treated with the Processed Polygala tenuifolia.

A total of 40 male SD rats were randomly divided into normal group, model group, Esazolam group, Processed Polygala tenuifolia low-dose group and Processed Polygala tenuifolia high-dose group with 8 rats in each group. D-galactose (D-gal) combined with p-chlorophenylalanine (PCPA) was used to prepare the rats with 'kidney failing to store willpower'. After successful modeling, the western medicine group was given Esazolam 0.2mg/kg/d by gavage, and the low dose Chinese medicine group was given Processed Polygala tenuifolia 2.1g/kg/d by gavage, the high dose group was given 4.2g/kg/d gavage, and the normal group and model group were given equal volume normal saline gavage for 7 days. Morris water maze test was used to evaluate the learning and memory ability of rats. HE and Nissl staining were used to observe the cell morphology and structure of rat brain. The expression levels of IL-4 and IL-18 in rat brain were detected by IHC and Western blot.

Compared with normal group, incubation period and total motor distance of rats in model group were significantly increased (P <0.01), the percentage of exploration time in the target quadrant was significantly reduced (P <0.01). The neuronal nucleus was dislocated, the nucleolus was enlarged, the inflammatory cells were infiltrated, and the number of nissl was significantly decreased (P < 0.01). The intercellular spaces of neuron cells are widened, and the synaptic structure is incomplete, and the expression level of IL-4 was significantly decreased (P <0.01), the expression level of IL-18 was significantly increased (P < 0.01). Compared with model group, latency and total distance of movement of rats in low dose group and high dose group were significantly decreased (P < 0.01), the percentage of exploration time in the target quadrant significantly increased (P < 0.01). The neuronal damage and inflammatory cell infiltration were alleviated to varying degrees, and the number of nissl was increased to varying degrees (P < 0.01). The morphology and structure of neuronal nucleosomes were improved to varying degrees, and the expression level of IL-4 was significantly increased (P < 0.01), the expression level of IL-18 was significantly decreased (P <0.01).

The Processed Polygala tenuifolia can significantly improve the sleep, learning and memory ability of insomnia model rats with 'kidney failing to store willpower', and alleviate the inflammatory damage state of the neurons in rats with 'kidney failing to store willpower'. The mechanism of improving the sleep of the rats with insomnia model rats with 'kidney failing to store willpower' may be related to the increase of IL-4 and the decrease of IL-18 expression level in the brain tissue.

To explore the clinical efficacy of modified Yanggan Powder combined with Sini Powder in the treatment of chronic hepatitis B (CHB) with liver depression, spleen deficiency, and blood stasis obstructing the collaterals.

A total of 122 CHB patients diagnosed in the Hai'an Traditional Chinese Medicine Hospital from April 2021 to December 2023 were randomly divided into an observation group (n=61) and a control group (n = 61) using a computer-generated random number method. The control group was treated with entecavir, while the observation group received a combination of modified Yanggan Powder and Sini Powder. After 6 months of treatment, the two groups were compared for TCM syndrome scores, liver function, HBV-DNA load, inflammatory factors (IL-1β, IL-6), liver function ultrasound indicators, therapeutic efficacy, and adverse reactions.

After treatment, both groups showed a reduction in TCM syndrome scores, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBiL), HBV-DNA load, IL-1β, and IL-6, with the observation group showing lower values than the control group (P <0.05). Both groups had an increase in albumin (ALB), with the observation group showing a higher increase than the control group. There were no significant changes in the hepatic portal vein diameter, splenic vein diameter, or spleen thickness before and after treatment in both groups (P > 0.05). The therapeutic efficacy rate in the observation group was higher than that in the control group (P <0.05). No serious adverse reactions were observed in either group.

Modified Yanggan Powder combined with Sini Powder is effective in treating HBV with liver qi stagnation, spleen deficiency, and blood stasis obstructing the channels, helping to relieve liver function symptoms, reduce inflammatory responses, and achieve good therapeutic effects.

To observe the efficacy of Shufeng Zhisou Decoction combined with montelukast sodium in the treatment of patients with cough variant asthma (CVA) and its influence on the airway inflammatory factors levels, pulmonary function and T lymphocyte immune balance.

104 CVA patients with pattern of wind pathogen attacking the lung were selected from September 2023 to July 2024 in Beijing Hepingli Hospital, and were divided into western medicine group (montelukast sodium on the basis of routine treatment) and combined group (Shufeng Zhisou Decoction on the basis of Western medicine group) according to the random number table method, 52 cases in each group. The clinical efficacy, TCM symptoms scores, airway inflammatory factors [fractional exhaled nitric oxide (FeNO), sputum eosinophil (EOS), sputum eosinophil cationic protein (ECP)], pulmonary function [forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in the first second as a percentage of predicted value (FEV1)] and T lymphocyte immune balance [interleukin-4 (IL-4), interferon-γ (IFN-γ), IFN-γ/IL-4] before and after treatment, adverse reactions and recurrence rate within 1 months of follow-up were compared between groups.

The combined group had higher total effective rate of treatment (90.38% vs 75.00%) than the Western medicine group (P <0.05). After treatment, the scores of cough, expectoration and pharyngeal pruritus in the two groups were decreased (P <0.05), and the scores in combined group [(0.60 ± 0.11) points vs(0.84 ± 0.14) points]、[(0.64 ± 0.11) points vs(0.87 ± 0.14) points]、[(0.68 ± 0.12) points vs(0.79 ± 0.14) points] were lower after treatment (P <0.05). The levels of FeNO, sputum EOS, ECP and serum IL-4 were reduced in both groups after treatment (P <0.05), FVC, PEF, FEV1, IFN-γ and IFN-γ/IL-4 in the two groups were enhanced (P <0.05), and there were statistical differences between groups after treatment (P <0.05).

Shufeng Zhisou Decoction combined with montelukast sodium can effectively improve the clinical symptoms and pulmonary function of CVA, relieve the airway inflammation, regulate the T lymphocyte immune imbalance, and improve the prognosis.

To investigate the clinical effect of Huanglian Qingjie Granule combined with improved combination therapy on spleen and stomach damp-heat type patients with chronic gastritis whose eradication of Helicobacter pylori (Hp) failed.

The research subjects were 82 patients with chronic gastritis of the spleen and stomach damp-heat type who failed the initial eradication of Hp and were admitted to Zhengzhou Hospital of Traditional Chinese Medicine from January 2023 to April 2025. They were divided into two groups according to a randomized, parallel controlled design: the control group and the treatment group, with 41 patients in each group. The control group was treated with modified double therapy, and the treatment group was treated with Huanglian Qingjie Granule on the basis of the control group. Both groups were treated for 1 month. The clinical efficacy of the two groups was compared. The Hp clearance of the two groups was compared one month after treatment. The TCM syndrome scores of the two groups were compared before treatment and one month after treatment. The levels of inflammatory factors were compared between the two groups before and 1 month after treatment.

Compared with the control group, the total effective rate was significantly higher in the treatment group (P < 0.05). Compared with control group, Hp clearance rate in treatment group was significantly higher (P < 0.05). Compared with the control group, the main symptom score and secondary symptom score of TCM syndrome score were significantly decreased in the treatment group one month after treatment (P < 0.05). Compared with the control group, the levels of tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1β) were significantly decreased in the treatment group one month after treatment, and the level of interleukin-10 (IL-10) was significantly increased in the treatment group (P < 0.05).

The combination of Huanglian Qingjie Granules and the modified dual therapy can effectively enhance the clinical efficacy of patients with chronic gastritis of spleen and stomach damp-heat type who have failed Hp eradication, increase the Hp eradication rate of patients, improve their TCM syndrome score and inflammatory factor levels, and can be widely applied in clinical practice.

To analyze the application value of mind-regulating acupuncture combined with sensory integration training in the language rehabilitation of children with autism.

A prospective study was conducted. A total of 93 children with autism admitted to the Department of Rehabilitation of Pingdingshan First People's Hospital from January 2024 to January 2025 were selected as the study subjects. They were randomly divided into a control group and an observation group using a random number table method, with 45 cases in each group. The control group received sensory integration training intervention, while the observation group received mind-regulating acupuncture combined with sensory integration training intervention. Both groups were continuously intervened for 6 months. The scores of the Autism Behavior Checklist (ABC), Children's Sensory Integration Development Rating Scale, Autism Treatment Evaluation Checklist (ATEC), and Childhood Autism Rating Scale (CARS) were compared between the two groups before treatment, at 3 months of treatment, and at 6 months of treatment.

Repeated measures ANOVA showed that the main effect of the group was statistically significant in the following scale scores (P <0.05) : Children's Sensory Integration Development Rating Scale, ATEC score, CARS score, and the sensory, social interaction, motor, language, and self-care dimensions of the ABC score. Further trend analysis indicated that the total ATEC score, total CARS score, and all dimension scores of the ABC showed a significant downward trend over time (P <0.05) ; the score of the Children's Sensory Integration Development Rating Scale showed a significant upward trend over time (P < 0.05).

Mind-regulating acupuncture combined with sensory integration training can improve the core symptoms of children with autism, enhance sensory integration ability, and has a good effect on language rehabilitation in these children.

To explore the effect of electroacupuncture combined with traditional Chinese medicine fumigation on skin barrier function in patients with moderate to severe atopic dermatitis (AD) of blood deficiency and wind dryness type.

Selected from April 2020 to October 2024, The case data of 96 AD patients admitted to the acupuncture and moxibustion and Massage Department of the First Affiliated Hospital of Xinjiang Medical University were selected, they were randomly divided into two groups, with 48 cases in each group. The control group received Western medicine treatment, while the observation group received electroacupuncture combined with traditional Chinese medicine fumigation treatment. The SCORAD score, skin barrier function indicators, immune function treatment before and after treatment were compared between the two groups, and the clinical efficacy and recurrence rate after 6 months of follow-up and adverse reaction incidence rate were also compared.

After treatment, the water content, sebum content, and interleukin-2 (IL-2) in the stratum corneum of both groups were significantly increased compared to before treatment (P < 0.05). SCORAD scores, transcutaneous water loss (TEWL), eosinophils (EOS), serum immunoglobulin E (IgE), and interleukin-4 (IL-4) were significantly reduced compared to before treatment (P <0.05), and the improvement was more significant in the observation group (P < 0.05). In terms of treatment efficiency, 97.92% in the observation group was significantly better than 81.25% in the control group (P < 0.05) ; The therapeutic effect efficiency was better in the observation group at 97.92% compared to the control group at 81.25% (P <0.05) ; The recurrence rate after 6 months of follow-up was significantly lower in the observation group at 16.67% compared to the control group at 56.25% (P <0.05) ;The incidence of adverse reactions in the observation group (4.17%) was lower than that in the control group (16.67%) (P < 0.05).

The combination of electroacupuncture combined with traditional Chinese medicinal fumigation for treating moderate to severe AD patients with blood deficiency and wind dryness is more effective than using Western medicine alone. It can effectively alleviate symptoms, improve skin barriers, regulate immune function, and prevent recurrence.

To explore the mechanism of promoting awakening effect and prognosis of coma patients with severe craniocerebral injury based on meridian flow theory combined with acupuncture.

A total of 102 coma patients with severe craniocerebral injury admitted to Xinxiang Central Hospital from October 2021 to October 2024 were divided into observation group and control group. The control group was given routine intervention. On the basis of the control group, the observation group was given meridian flow theory combined with acupuncture treatment. The waking time, waking rate, GCS and FOUR scores and prognosis were compared between the two groups. The levels of neuron-specific enolase (NSE), S100B protein (S-100B) and myelin basic protein (MBP) were compared between the two groups before and after treatment. The improvement of cerebral blood flow (CBF) and cerebral blood volume (CBV) before and after treatment was compared between the two groups.

The awakening rate of observation group was 82.35% higher than that of control group 64.71%, and the awakening time was significantly lower than that of control group (P <0.05). After 10 and 30 days of treatment, GCS and FOUR scores of both groups significantly increased, and the observation group was significantly higher than the control group (P <0.05) ; After treatment, NSE, S-100B and MBP significantly decreased in both groups, and the observation group was significantly lower than the control group (P < 0.05). After treatment, CBF and CBV significantly increased in both groups, and the observation group was significantly higher than the control group (P <0.05). Compared with 68.63% of the control group, the total effective rate of the observation group was 86.27% (P < 0.05).

Acupuncture combined with meridian injection theory can significantly improve the awakening rate of coma patients with severe craniocerebral injury, improve nerve function and cerebral blood flow indexes, and the prognostic effect is better than conventional treatment.

To investigate the clinical efficacy of ZHU's chiropractic manipulation combined with Jianyao Pill in patients with lumbar disc herniation (LDH) accompanied by liver and kidney deficiency syndrome.

A retrospective analysis was conducted on the clinical data of 201 patients with liver-kidney deficiency type of lumbar disc herniation (LDH) treated at the Cervical-Lumbar Pain Diagnosis and Treatment Center of Changzhou Hospital of Traditional Chinese Medicine between February 2024 and December 2024. Patients were divided into an observation group and a control group based on treatment protocols. The control group (100 cases) received Jianyao Pill therapy, while the observation group (101 cases) received ZHU's spinal manipulation therapy in addition to the control group's treatment. Both groups underwent a 4-week treatment course. Clinical efficacy, lumbar function [modified Oswestry Disability Index (ODI), lumbar flexion range (LFR), and lumbar flexion/extension muscle strength], pain status [Simplified McGill Pain Questionnaire (SF-MPQ), pressure pain threshold (PPT) at tender points], and adverse reaction rates were evaluated.

The total effective rate was significantly higher in the observation group than in the control group (P <0.05). Post-treatment, both groups showed reduced ODI and SF-MPQ scores compared to baseline (P < 0.05), with greater reductions in the observation group (P < 0.05). LFR, lumbar flexion/extension muscle strength, and PPT levels increased in both groups (P <0.05), with higher values in the observation group (P <0.05). No significant difference in adverse reaction rates was observed between groups (P >0.05).

ZHU's chiropractic manipulation combined with Jianyao Pill demonstrates significant efficacy in improving lumbar function and alleviating pain in LDH patients with liver-kidney deficiency syndrome, with a favorable safety profile.