Full
Outline
Diyu（Sanguisorbae Radix）is a traditional Chinese medicine，that cools blood to stop bleeding，and relieves toxin to heal sores. However，New Compilation of Materia Medica highlights its dual function of stop bleeding and replenishing blood. At the same time，the prescription books of the past dynasties also recorded the application of Diyu（Sanguisorbae Radix）in replenishing blood. Modern pharmacological studies have confirmed that Diyu（Sanguisorbae Radix）has the effect of increasing white blood cells，red blood cells and platelets. Among them，Diyu Shengbai Tablet（地榆升白片）which is the preparation only with Diyu（Sanguisorbae Radix）can significantly improve the clinical symptoms of patients by increasing the white blood cell count，restoring peripheral blood image and increasing the number of platelets. Triterpenoid saponins in Diyu（Sanguisorbae Radix）can up-regulate Extracellular Signal-Regulated Kinase（ERK）and express and activate Nucleotide-binding Oligomerization Domain-like Receptor（NOD）signaling pathway to promote bone marrow cell proliferation. Phenolic acids promote the proliferation and differentiation of megakaritic progenitors by up-regulating the expression of thrombopoietin（TPO）and tumor necrosis factor-alpha（TNF-α）. Although the blood-tonic effect of Diyu（Sanguisorbae Radix）has been preliminarily confirmed，the connotation of its blood-tonic effect was still fully clarified. To this end，this paper systematically combed the ancient and modern literature related to Diyu（Sanguisorbae Radix）from the Han Dynasty to the present，and analyzed the literature on the blood-tonic effect of Diyu（Sanguisorbae Radix）based on the records of traditional materia medica，prescription books，clinical applications and modern pharmacological research in order to further clarify the understanding of the blood-tonic effect of Diyu（Sanguisorbae Radix）and expand the clinical application of Diyu（Sanguisorbae Radix）in blood-tonic-related fields.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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