Full
Outline
To investigate the effect of Banxia Xiexin Decoction（半夏泻心汤）on Notch signaling pathway in Nmethyl-N'-nitro-N-nitrosoguanidine（MNNG）-induced gastric cancer model rats.
Fifty SD rats were randomly divided into control group，model group and Banxia Xiexin Decoction group. The control group was fed normally，and the model group and Banxia Xiexin Decoction group were treated with“MNNG gavage＋free drinking method”to induce gastric cancer model. The gastric pathological histology was observed by hematoxylin-eosin（HE）staining. Notch signaling pathway related protein expression was detected by Western Blot，and Notch signaling pathway related protein and Ki67 and VEGFA expressions were detected by immunohistochemistry method.
The incidence of tumor was 75.0%（6/8）in the model group and 33.3%（3/9）in the Banxia Xiexin Decoction group. Western Blot analysis showed that the expressions of Notch1，Jagged1，Dll4 and Hes1 in gastric tissue of rats in the model group were increased compared with those in the control group（P<0.05），and the above proteins were significantly decreased after Banxia Xiexin Decoction intervention compared with those in the model group（P<0.05）. The immunohistochemical results showed that the average optical density of Ki67，VEGFA，Notch1，Jaggedl，Dll4 and Hes1 in the model group was significantly higher than that in the control group（P<0.05），and the average optical density of these proteins after the intervention of Banxia Xiexin Decoction was significantly lower than that in the model group（P<0.05）.
Banxia Xiexin Decoction can intervene Notch signaling pathway，regulate the expressions of VEGF and Ki67，and inhibit the occurrence and development of gastric cancer to a certain extent.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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