To study the changes in endothelin（ET），serum neuropeptide Y（NPY）and substance P（SP）in patients treated with Modified Jichuan Decoction（济川煎加味）combined with abdominal acupuncture for slow-transmitting constipation with Yang-deficiency of spleen and kidney.

Ninety-four patients with slow-transmission constipation（Yang-deficiency of spleen and kidney）were divided into two groups by using random number method. The two groups were given general treatment，such as regular life，balanced diet，appropriate participation in physical exercise，drinking more water，etc. The Mosapride group was treated with Mosapride，and the Jichuan Decoction group was given Modified Jichuan Decoction combined with abdominal acupuncture on the basis of the Mosapride group. The time of first defecation，constipation symptom scores（including difficulty in defecation，frequency，time and faecal character，feeling of falling and incompletion，abdominal distension），the points of the Patient's Assessment of Quality of Life Scale（PAC-QOL）for constipated patients and the changes of ET，nitric oxide（NO），NPY and SP were compared between the two groups.

The overall time to first defecation in the Jichuan Decoction group was statistically better than that in the Mosapride group（P<0.05）. There was no statistical significance when comparing the scores of constipation symptoms such as difficulty in defecation，frequency，time and faecal characteristics，feeling of incompleteness and abdominal distension before treatment between the two groups（P>0.05）. The constipation symptom scores of Jichuan Decoction group and Mosapride group were lower after treatment than before treatment，and the constipation symptom scores of Jichuan Decoction group were lower than those of Mosapride group after treatment（P<0.05）. There was no statistical significance in the comparison of ET，NO，NPY or SP before treatment between the two groups（P>0.05）. The levels of ET，NO and NPY decreased and the level of SP increased after treatment in the Jichuan Decoction group and the Mosapride group compared with those before treatment（P<0.05）. The level of SP was higher in the Jichuan Decoction group than that in the Mosapride group，and the levels of ET，NO and NPY were lower than those in the Mosapride group after treatment（P<0.05）. There was no statistical significance in the comparison of PAC-QOL score before treatment between the two groups（P>0.05）. The PAC-QOL scores of Jichuan Decoction group and Mosapride group were lower after treatment than those before treatment，and the PAC-QOL scores of Jichuan Decoction group were lower than those of Mosapride group after treatment（P<0.05）.

Modified Jichuan Decoction combined with abdominal acupuncture can regulate the expression levels of ET，NO，NPY and SPin patients with slow-transmitting constipation with Yang-deficiency of spleen and kidney，improve the symptoms of constipation，promote the initial defecation and improve the quality of life.