To observe the effect of Astragalus Polysaccharide Injection combined with intensity modulated conformal radiotherapy in the treatment of advanced cervical cancer.

A total of 82 patients with advanced cervical cancer admitted from February 2021 to December 2023 were included in this study. The patients were divided into two groups by random number table method，namely radiotherapy group and Chinese patent medicine group，with 41 cases in each group. All patients received conventional chemotherapy treatment，while the patients in the radiotherapy group also received intensity-modulated radiotherapy treatment. Those in the Chinese patent medicine group were treated with Astragalus Polysaccharide Injection on the basis of radiotherapy group，and the data of patients in each group was observed and compared，including the efficacy and adverse reactions，the changes of TCM symptom scores（hypoabdominal distention，weakness，shortness of breath，pale complexion，etc.）before and after treatment，squamous cell cancer（SCC），the changes in the levels of tumor markers such as carbohydrate antigen 125（CA125）and carcinoembryonic antigen（CEA），the changes in immune function indicators such as helper T cells，cytotoxic T cells，helper T cells/cytotoxic T cells，and EORTC Quality of Life scale（European Organization for Research and Treatment of Cancer）Cancer Quality of Life Questionnaire，EORTCQLQ-C30）score changes.

The total effective rate in the Chinese patent medicine group was significantly higher than that in the radiotherapy group（P<0.05）. The decrease rate of leukocyte in the Chinese patent medicine group was lower than that in the radiotherapy group（P<0.05）. The incidence of other adverse reactions was similar between the two groups（P>0.05）. The comparison of TCM syndrome scores（hypoabdominal distention，weakness，shortness of breath，pale complexion，etc.），tumor marker levels（CA125 and CEA），helper T cells，cytotoxic T cells，helper T cells/cytotoxic T cells，EORTCQLQ-C30 score and other indicators in both groups before treatment was not significant（P>0.05）. After treatment，TCM syndrome scores（hypoabdominal distention，weakness，shortness of breath，pale complexion，etc.）and tumor marker levels（SCC，CA125 and CEA）were all decreased in both groups，and EORTC QLQ-C30 scores were all increased，and the decrease and improvement degree of indexes in the Chinese patent medicine group were significantly higher than those in the radiotherapy group（P<0.05）. After treatment，helper T cells decreased，cytotoxic T cells increased，and helper T cells/cytotoxic T cells decreased in both groups. The degree of decline and increase of various indexes in the Chinese patent medicine group was lower than that in the radiotherapy group（P<0.05）.

Polysaccharide Injection combined with intensity modulated conformal radiotherapy has a good effect in the treatment of advanced cervical cancer，which can effectively reduce tumor markers，improve disease conditions and enhance immune function and quality of life of patients. The treatment is tolerable and relatively safe and feasible.