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Research Progress on Anti-Angiogenesis and Anti-Tumor of Natural Compounds by Inhibiting VEGF
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Ningning ZHAO1, 2, Yiyang HU1, 2, Yingying XIE1, 2, Chunzheng MA1, Peimin LIU1, Dongdong LI1, Juan ZHANG1, 2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(10) : 155 - 160
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(10): 155-160
• Target on National Project •
Research Progress on Anti-Angiogenesis and Anti-Tumor of Natural Compounds by Inhibiting VEGF
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Ningning ZHAO1, 2, Yiyang HU1, 2, Yingying XIE1, 2, Chunzheng MA1, Peimin LIU1, Dongdong LI1, Juan ZHANG1, 2
Affiliations
  • 1.The Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，Henan，China
  • 2.The Second Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
Published: 2025-10-10 doi: 10.13193/j.issn.1673-7717.2025.10.029
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Malignant tumor is a disease that seriously endangers human health.Angiogenesis is one of the important mechanisms of the occurrence and development of malignant tumors.Vascular endothelial growth factor（VEGF）is widely regarded as the main regulator of angiogenesis and plays an extremely important role in the process of angiogenesis.Targeting VEGF and vascular endothelial growth factor receptor（VEGFR）can reduce angiogenesis in tumor and help to inhibit tumor invasion，proliferation and metastasis，which is one of the important fields of medical research.Natural compounds are widely defined as chemical substances produced by organisms，which have unique chemical diversity，wide sources，multi-targets，multi-mechanisms，multi-channels，low toxic and side effects.Modern studies have confirmed that natural compounds exert an anti-tumor effect on inhibiting angiogenesis by inhibiting VEGF，and natural compounds have obvious therapeutic advantages for malignant tumors，which can effectively inhibit the occurrence and development of tumors and improve the quality of life of cancer patients.In this paper，the related research of natural compounds on anti-angiogenesis and anti-tumor through inhibiting VEGF was summarized，and the main mechanism of VEGF/VEGFR signaling pathway was combed，so as to provide reference for the optimization of clinical malignant tumor treatment strategy.

natural compounds  /  malignant tumor  /  VEGF  /  angiogenesis  /  research progress
赵宁宁, 胡亦杨, 谢瑛莹, 马纯政, 刘培民, 李东东, 张娟. 天然化合物通过抑制VEGF抗血管生成抗肿瘤的研究进展. 中华中医药学刊, 2025 , 43 (10) : 155 -160 . DOI: 10.13193/j.issn.1673-7717.2025.10.029
Ningning ZHAO, Yiyang HU, Yingying XIE, Chunzheng MA, Peimin LIU, Dongdong LI, Juan ZHANG. Research Progress on Anti-Angiogenesis and Anti-Tumor of Natural Compounds by Inhibiting VEGF[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (10) : 155 -160 . DOI: 10.13193/j.issn.1673-7717.2025.10.029
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Year 2025 volume 43 Issue 10
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doi: 10.13193/j.issn.1673-7717.2025.10.029
  • Online Date：2026-10-30
  • Published：2025-10-10
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    1.The Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，Henan，China
    2.The Second Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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