To investigate the effects of Yiqi Yangrong Decoction（益气养荣汤）combined with acupuncture on T lymphocyte subpopulation and serum levels of granin A（CGA），soluble intercellular adhesion factor-1（slCAM-1）and human growth differentiation factor 3（GDF3）in patients with syndrome of both Qi and blood deficiency after breast cancer surgery.

Ninety-two patients with syndrome of both Qi and blood deficiency after breast cancer surgery were treated in the hospital from May 2020 to May 2023.They were divided into the control group and the test group，46 cases in each group，using random number table method.The control group was treated with CEF（Cyclophosphamide，Epirubicin，Fluorouracil）chemotherapy，and the test group was treated with Yiqi Yangrong Decoction combined with acupuncture and moxibustion on the basis of CEF chemotherapy，21 days for 1 cycle，a total of 4 cycles.The quality of life，the serum levels of CGA，slCAM-1，GDF3 and T lymphocyte subsets of the two groups before and after 4 cycles of treatment，the efficacy after 4 cycles of treatment，and the occurrence of adverse reactions during treatment were compared.

Compared with those before treatment，after 4 cycles of treatment，the functional dimension and overall quality of life scores of the two groups were increased，and those of the test group were significantly higher（P<0.05）.Compared with those before treatment，the symptom dimension scores/serum levels of CGA，slCAM-1 and GDF3 were decreased after 4 cycles of treatment，and the scores and levels were significantly lower in the test group（P<0.05）.Compared with those before treatment，the levels of CD4⁺and CD4⁺/CD8⁺in whole blood of the test group were increased after 4 cycles of treatment，and those of the control group were decreased.The levels were significantly higher in the test group（P<0.05）.The level of CD8⁺in whole blood of the test group decreased，and that of the control group increased.The level of CD8⁺in the test group was significantly lower（P<0.05）.The total effective rate of the test group was 83.33%（35/42），significantly higher than that of the control group（61.36%，27/44）after 4 cycles of treatment（P<0.05）.During the treatment period，no obvious adverse reactions occurred in the test group and the incidence of adverse reactions in the test group was significantly lower（P<0.05）.

Yiqi Yanggrong Decoction combined with acupuncture can regulate the levels of T lymphocyte subsets in patients with syndrome of both Qi and blood deficiency after breast cancer surgery，inhibit the serum levles of CGA，slCAM-1 and GDF3，control the abnormal proliferation of cancer cells，improve the quality of life，and reduce the risk of postoperative chemotherapy complications.