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Research Progress on Mechanism of PI3K/AKT Signaling Pathway Regulating Asthma and Traditional Chinese Medicine Treatment
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Ziqi ZHOU1, Lizhe LIANG2, Guoxin LI2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(10) : 161 - 166
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(10): 161-166
• Target on National Project •
Research Progress on Mechanism of PI3K/AKT Signaling Pathway Regulating Asthma and Traditional Chinese Medicine Treatment
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Ziqi ZHOU1, Lizhe LIANG2, Guoxin LI2
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
  • 2.The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China
Published: 2025-10-10 doi: 10.13193/j.issn.1673-7717.2025.10.030
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Asthma is a highly prevalent disease around the world，with a low control rate and a certain risk of death.At present，there are many adverse reactions of hormonal drugs that improve asthma，so it is imperative to find new treatments.In recent years，traditional Chinese medicine has become popular in the treatment of asthma due to its advantages of multiple ingredients，multiple targets，multiple pathways and few side effects.Phosphatidylinositol 3-kinase/protein kinase B（PI3K/AKT），as a classical pathway widely existing in organisms，plays an important role in regulating cell growth，proliferation，differentiation and autophagy.The active ingredients of traditional Chinese medicine，traditional Chinese medicine compounds and preparations exert anti-inflammation，anti-oxidative stress，anti-pyroptosis，regulate the dominant response of immune cells and autophagy，and reduce the airway remodeling by regulating the PI3K/AKT signaling pathway，so as to improve the course of asthma.In order to facilitate scholars to fully grasp the research status of this research in recent years，this paper reviewed the latest mechanism research on the treatment of asthma based on the PI3K/AKT signaling pathway，in order to provide new ideas for scientific research，clinical and new drug researches.

asthma  /  PI3K/AKT  /  traditional Chinese medicine  /  research progress
周子齐, 梁丽喆, 李国信. PI3K/AKT信号通路调控哮喘机制及中药治疗研究进展. 中华中医药学刊, 2025 , 43 (10) : 161 -166 . DOI: 10.13193/j.issn.1673-7717.2025.10.030
Ziqi ZHOU, Lizhe LIANG, Guoxin LI. Research Progress on Mechanism of PI3K/AKT Signaling Pathway Regulating Asthma and Traditional Chinese Medicine Treatment[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (10) : 161 -166 . DOI: 10.13193/j.issn.1673-7717.2025.10.030
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Year 2025 volume 43 Issue 10
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doi: 10.13193/j.issn.1673-7717.2025.10.030
  • Online Date：2026-10-30
  • Published：2025-10-10
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    1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China
    2.The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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