To investigate the efficacy of Huadu Quxie Decoction（化毒祛邪汤）combined with CHOPchemotherapy in the treatment of lymphoma and its effect on cellular immune function.

A total of 102 patients with lymphoma treated in the hospital from January 2020 to December 2023 were selected as research objects，and the patients were divided into control group（51 cases）and observation group（51 cases）according to random number table method.The control group was treated with CHOP chemotherapy，and the observation group was treated with Huadu Quxie Decoction on the basis of the control group.Four weeks was a treatment cycle，and both groups received 4 cycles of treatment.After 4 cycles of treatment，the clinical efficacy of the two groups was compared，and the changes of cellular immune function（CD⁺₄，CD⁺₈，CD⁺₄/CD⁺₈），tumor markers［vascular endothelial growth factor（VEGF）and thymine deoxyribokinase（TK-1）］were compared before treatment and after 4 cycles of treatment，and the occurrence of adverse reactions during treatment was recorded.

The total effective rate of the observation group after treatment was significantly higher than that of the control group，and the difference was statistically significant（P<0.05）.The levels of cellular immune function indexes（CD⁺₄，CD⁺₈，CD⁺₄/CD⁺₈）in the observation group were significantly higher than those in the control group after treatment，and the difference were statistically significant（P<0.05）.The levels of VEGF and TK-1 in the observation group were significantly lower than those in the control group after treatment，and the difference were statistically significant（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups during treatment（P>0.05）.

Huadu Quxie Decoction combined with CHOP chemotherapy has significant efficacy in the treatment of lymphoma，and can improve the cellular immune function of patients and reduce the expressions of VEGF and TK-1 in serum，worthy of clinical promotion and application.