To analyze the clinical effect of Modified Xiaoke Decoction（消渴方加减）treating patients with type 2 diabetic nephropathy（Qi deficiency and blood stasis type）.

A total of 220 patients with type 2 diabetic nephropathy of Qi deficiency and blood stasis type admitted to the Department of Endocrinology and Nephrology of Ziyang Hospital of Traditional Chinese Medicine from June 2020 to June 2024 were included as the research objects.They were divided into two groups by the random number table method.A hundred and ten patients in the control group were treated with conventional western medicine treatment，and the other 110 patients in the observation group were treated with Modified Xiaoke Decoction on this basis.The treatment effects，TCM symptom scores，blood glucose indexes，isletβcell functions，renal function indexes and changes in oxidative stress indexes of the two groups were compared.

The total effective rate of the observation group was 97.28%（107/110），which was much higher than that of the control group（82.73%，91/110），and the difference between the groups was significant（P<0.05）.After treatment，the levels of fasting blood glucose（FPG），2-hour postprandial blood glucose（2 h PBG），glycated hemoglobin（HbA1c）and homeostasis model assessment of insulin resistance（HOMA-IR）in the observation group were lower than those in the control group，and homeostasis model assessment-β（HOMA-β）was higher than that in the control group（P<0.05）.After treatment，the levels of 24-hour urinary protein and urinaryβ₂-microglobulin（β₂ MG）in the observation group were lower than those in the control group（P<0.05）.After treatment，the levels of superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px）in the observation group were higher than those in the control group，and the level of malondialdehyde（MDA）was lower than that in the control group（P<0.05）.

The application of Modified Xiaoke Decoction in patients with type 2 diabetic nephropathy of Qi deficiency and blood stasis type can effectively reduce the blood glucose level，improve insulin resistance and isletβcell function，inhibit the oxidative stress reaction，protect renal function，reduce damage，and has a positive effect on the improvement of the prognosis of patients.