To observe the clinical effect of Fupi Yishen Recipe（扶脾益肾方）combined with manual root surface leveling in the treatmentof severe chronic periodontitis（spleen-kidney Yang deficiency type）and its effecton inflammatory factors.

A total of 102 patients with severe chronic periodontitis（spleen-kidney-yang deficiency type）admitted from January 2020 to January 2024 were included in the group study. The patients were divided into the simple operation group and the combined Chinese medicine group by random number tablemethod，with 51 cases in each group. All patients in the simple operation group received manual root planarization treatment. Those in the combined Chinese medicine group were treated with manual root surface leveling and Fupi Yishen Recipe. During the treatmentand study，1 patient in the simple operation group fell off，and 2 patients in the combined Chinese medicine group fell off. The clinical efficacy，integral changes of TCM symptoms（main symptoms，secondary symptoms and tongue and pulse）before and after treatment，the changes of periodontal index and concentration of inflammatory factors in gingival crevicular fluid，the changes of masticatory function（bite force and masticatory efficiency）and the adverse reactions of treatmentof two groupswere observed.

The total effective rate of the combined Chinese medicine group was higher than thatof the operation group（P<0.05）. Before treatment，the scores of TCM symptoms（main symptoms，secondary symptoms and tongue and pulse），periodontal indices such as gingival bleeding index（BI），plaque index（PLI）and loss ofattachment（AL），depth of periodontal probe（PD），concentration of inflammatory factors such as tumor necrosis factor-α（TNF-α）and interleukin-1β（IL-1β）in gingival crevicular fluid，and chewing function（biting force）of patients in both groups had no significance（all P>0.05）. After treatment，the above indexes were all improved and those in the combined Chinese medicine group were better than those in the simple operation group（all P<0.05）. No serious adverse reactions were observed in the combined Chinese medicine group and the simple operation group（P>0.05）.

Fupi Yishen Recipe combined with manual root surface leveling has significant clinical effect in the treatment of severe chronic periodontitis（spleen-kidney Yang deficiency type），which can effectively reduce the concentration of inflammatory factors in gingival crevicular fluid，improve the clinical symptoms，periodontal index and masticatory function of patients and promote the recovery of patients. The treatment is relatively safe and reliable.