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Outline
Functional dyspepsia（FD）is a relatively common digestive disease in clinical practice，and there is no functional dyspepsia in traditional Chinese medicine，but according to its clinical manifestations，it can be included in the categories of“stuffiness and fullness”，“gastric pain”，“stagnation”and“accumulation”. Through reviewing the literature，the author has found that FD is located in the stomach and has a close relationship with liver，spleen and heart，mostly due to the onset of external evils，dietary irregularities and deficiency of spleen and stomach，which ultimately leads to an imbalance in the function of spleen ascending and stomach descending，and an imbalance in the human body＇s Qi，thus leading to the occurrence of FD. Zhizhu Pill（枳术丸）was firstly transformed from ZHANG Zhongjing＇s Zhizhu Decoction（枳术汤），then improved by WANG Kuang in Song Dynasty and LIU Wansu in Jin Dynasty，and was firstly mentioned in Discussion of Internal and External Injuries and Prohibition of Dietary Use of Medicines for Internal and External Injuries by LI Dongyuan. Zhizhu Pill has the efficacy of strengthening spleen and eliminating stuffiness and fullness，and has been widely used by doctors in the following generations for the treatmentof diseases of spleen and stomach. Clinical studies have found that Zhizhu Pill is often used in the treatment of FD，either as a single formula with additions and subtractions，or in combination with Xiangsha LiujunziDecoction（香砂六君子汤），Chaihu Shugan Powder（柴胡疏肝散），western medicines and moxibustion，in order to improve the efficacy of the treatment，minimize the side-effects and reduce the recurrence rate. Experimental studies have found that the mechanism of action of Zhizhu Pill for FDmay be related to the regulation of the brain-gutaxis，reduction of visceral hypersensitivity，regulation of gastrointestinal function and restoration of intestinal flora dysbiosis. This paper discussed the theoretical research，clinical experiment and mechanism of action，aiming to study the progress of Zhizhu Pill in treating FD，in order to provide broader ideas for clinical diagnosis and treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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