To explore the curative effect of Diwu Yanggan Prescription（地五养肝方）combined with laparoscopic hepatectomy in the treatment of primary liver cancer and the prevention of recurrence.

A total of74 patients with primary liver cancer（admitted from January 2020 to September2022）were included，and the patientswere divided into a simple operation group（37 cases）and a combined traditional Chinese and Western medicine group（37 cases）by random number table method. All patients in the simple operation group were treated with laparoscopic hepatectomy，while those in the combined traditional Chinese and Western medicine group were treated with Diwu Yanggan Prescription combined with laparoscopic hepatectomy. During the study，there were 2 cases shedding in the combined traditional Chinese and western medicine group and 1 case in the simple operation group. The data in each group was observed，including the efficacy，visual analogue scale（VAS）3 and 5 days after surgery，complications，postoperative exhaust and first time，length of hospital stay，changes in total TCM symptom scores before and after treatment，the changes of direct bilirubin（DBIL），aspartate transaminase（AST）and glutamic pyruvic transaminase（ALT），the levels of interleukin-6（IL-6），C-reactive protein（CRP）and tumor necrosis factor alpha（TNF-α）7 days after surgery，the levels of alpha-fetoprotein（AFP）and matrix metalloproteinase-9（MMP-9）before and after treatment，the tumor recurrence rate 6months and 1 year after surgery.

The total effective rate of the combined traditional Chinese and Western medicine group was higher than that of the simple operation group（P<0.05）. The VAS scores of the combined traditional Chinese and Western medicine group were lower than those of the simple operation group 3 d and 5 d after surgery（P<0.05）. The complication rate of integrated traditional Chinese and Western medicine group was lower than that of the simple operation group（P<0.05）. The postoperative exhaust，the first time and the length of hospital stay in the combined traditional Chinese and Western medicine group were shorter than those in the simple operation group（P<0.05）. After treatment，liver function indexes（DBIL，AST，ALT）in the combined traditional Chinese and Westernmedicine group was better than that in the simple operation group，the total TCM symptom score was lower than that in the simple operation group，the levels of AFP and MMP-9 were significantly lower than those in the simple operation group（P<0.05）. The levels of IL-6，CRP and TNF-αin the combined traditional Chinese and Western medicine group were lower than those in the simple operation group 7 days after surgery（P<0.05）. Sixmonths after operation，the recurrence rate of both groupswas not significant（P>0.05）. One year after the operation，the recurrence rate of the combined traditional Chinese and Westernmedicine group was lower than that of the simple operation group（P<0.05）.

Diwu Yanggan Prescription combined with laparoscopic hepatectomy has good efficacy in the treatment of primary liver cancer，with improved symptoms and liver function，good postoperative recovery，light pain，rapid recovery，fewer complications，safety and reliability，and can better prevent the tumor recurrence after 1 year，which isworthy of application.