To explore the risk factors of elderly patients with coronary heart disease（CHD）and weakness and the effect of using traditional Chinese medicine Gancao Xiexin Decoction（甘草泻心汤）combined with Modified LI Ke’s Shensiwei（李可肾四味加减）.

A total of 120 elderly CHD patients complicated with weakness who received the treatment in the hospital from February 2020 to February 2021 were as the weakness group，and another 120 elderly CHD patients without weakness were as the non weakness group to analyze the risk factors that caused weakness. The weakness group was randomly divided into a combination group and a Western medicine group，with 60 cases in each. The Western medicine group received conventional Western medicine treatment，while the combination group received additional treatment with Gancao Xiexin Decoction combined with Modified LI Ke’s Shensiwei on the basis of the Western medicine group. The treatment courses were both 12 weeks，and the differences in treatment effects between the two groups were compared.

（1）According to Logistic regression model analysis，decreased body mass index（BMI），complicated with acute coronary syndrome，increased Mini Nutritional Assessment Short Form（MNA-SF）score and Charlson comorbidity index were independent risk factors for weakness in elderly CHD patients（P<0.05）. Increased Charlson comorbidity index was an independent risk factor for weakness in elderly CHD patients（P<0.05）. The elevated levels of albumin（ALB）and total protein（TP）can effectively reduce the risk of weakness in elderly CHD patients and were protective factors（P<0.05）.（2）Before treatment，there was no significant difference in serum hemoglobin（Hb），ALB，TP or prealbumin（PA）between the Western medicine group and the combination group（P>0.05）. After treatment，the serum levels of Hb，ALB，TP and PA of the two groups were significantly increased compared to those before treatment（P<0.05），while the serum levels of Hb，ALBand PA of the combination group were higher than those of the Western medicine group（P<0.05）. Before treatment，the grip strength，the levels of Timed Up and Go Test（TUG）and Functional Sit-to-Stand Test（FTSS）between the western and combination groups were not significant（P>0.05）. After treatment，the grip strength of both groups was significantly improved and the levels of TUG and FTSS were significantly reduced（P<0.05）. The grip strength in the combination group was higher than that in the Western medicine group，and the TUGwas lower than that in the Western medicine group（P<0.05）.

Malnutrition and comorbidities are risk factors for concurrent weakness in elderly CHD patients. On the basis of the basic treatment plan of Western medicine，the addition of traditional Chinese medicine Gancao Xiexin Decoction combined with Modified LI Ke’s Shensiwei can significantly improve the treatment effect.