To evaluate the effect of kidney-tonifying method and ibandronate based on lung-kidney-bone axis in the treatment of lung cancer bone metastasis and the monitoring value of CT for prognosis.

A total of 92 patients with lung cancer bone metastasis were included from September 2020 to September 2023. All patients were obtained from the hospital and it was a retrospective analysis. All patients were divided into group A（46 cases，treated with ibandronic acid）and group B（46 patients，treated with kidney-tonifying method based on lung-kidney-bone axis combined with ibandronate）.TCM syndrome scores，KPSscores，serum tumor marker levels，levels of serotonin（5-HT），prostaglandin E2（PGE2）and endothelin-1（ET-1），and the CT values of osteolytic，osteogenic and mixed bone metastasis before and after treatment were compared between two groups.

After treatment，the scores of both groups decreased compared to that before treatment，and the score of group B decreased compared to that of group A.KPSscores increased compared to those pre-treatment，and the KPSscore of group B increased compared with that of group A. The serum levels of glucose antigen 125（CA125），glucose antigen 199（CA199）and cytokeratin fragment 19（CYFRA21-1）were all decreased compared to those before treatment，and the above indexes of patients in group B decreased compared with those in group A. The serum levels of 5-HT，PGE2 and endothelin-1 were all decreased compared to those before treatment，and the above indexes of patients in group B decreased compared with those in group A. The CT value of bone metastases of osteolytic and mixed lung cancer gradually increased at 3 and 6 months after treatment. Moreover，the CT value of different types of lung cancer increased at 6 months compared with that at 3 months after treatment（all P<0.05）.

The combination of kidney-tonifying method and ibandronate based on the lungkidney-bone axis in the treatment of lung cancer bone metastasis patients can help to alleviate the clinical symptoms，improve the physical function，reduce the serum tumor marker levels and have significant analgesic effects. At the same time，MSCT examination can be used to evaluate the treatment effect of lung cancer bone metastasis patients.